Double-emulsion drops with ultra-thin shells for capsule templates

Lab on a Chip ◽  
2011 ◽  
Vol 11 (18) ◽  
pp. 3162-3166 ◽  
Author(s):  
Shin-Hyun Kim ◽  
Jin Woong Kim ◽  
Jun-Cheol Cho ◽  
David A. Weitz
Keyword(s):  
Double Emulsion ◽  
Thin Shells ◽  
Emulsion Drops

scholarly journals Correction: Double-emulsion drops with ultra-thin shells for capsule templates

Lab on a Chip ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. 567-567 ◽  
Author(s):  
Shin-Hyun Kim ◽  
Jin Woong Kim ◽  
Jun-Cheol Cho ◽  
David A. Weitz
Keyword(s):  
Double Emulsion ◽  
Thin Shells ◽  
Emulsion Drops

Correction for ‘Double-emulsion drops with ultra-thin shells for capsule templates’ by Shin-Hyun Kim et al., Lab Chip, 2011, 11, 3162–3166.

scholarly journals Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 444 ◽  
Author(s):  
Jianhua Guo ◽  
Lihua Hou ◽  
Junpeng Hou ◽  
Jiali Yu ◽  
Qingming Hu
Keyword(s):  
Thin Shell ◽  
Shell Thickness ◽  
Double Emulsion ◽  
Spherical Shape ◽  
Thin Shells ◽  
Biomolecular Sensing ◽  
Oil In Water ◽  
Emulsion Drops ◽  
Long Term Observation

Microcapsules are attractive core-shell configurations for studies of controlled release, biomolecular sensing, artificial microbial environments, and spherical film buckling. However, the production of microcapsules with ultra-thin shells remains a challenge. Here we develop a simple and practical osmolarity-controlled swelling method for the mass production of monodisperse microcapsules with ultra-thin shells via water-in-oil-in-water (W/O/W) double-emulsion drops templating. The size and shell thickness of the double-emulsion drops are precisely tuned by changing the osmotic pressure between the inner cores and the suspending medium, indicating the practicability and effectiveness of this swelling method in tuning the shell thickness of double-emulsion drops and the resultant microcapsules. This method enables the production of microcapsules even with an ultra-thin shell less than hundreds of nanometers, which overcomes the difficulty in producing ultra-thin-shell microcapsules using the classic microfluidic emulsion technologies. In addition, the ultra-thin-shell microcapsules can maintain their intact spherical shape for up to 1 year without rupturing in our long-term observation. We believe that the osmolarity-controlled swelling method will be useful in generating ultra-thin-shell polydimethylsiloxane (PDMS) microcapsules for long-term encapsulation, and for thin film folding, buckling and rupturing investigation.

scholarly journals Scalable production of double emulsion drops with thin shells

Lab on a Chip ◽  
2018 ◽  
Vol 18 (13) ◽  
pp. 1936-1942 ◽  
Author(s):  
A. Vian ◽  
B. Reuse ◽  
E. Amstad
Keyword(s):  
High Throughput ◽  
Shell Thickness ◽  
Double Emulsion ◽  
Thin Shells ◽  
Double Emulsions ◽  
Emulsion Drops ◽  
Scalable Production

The microfluidic aspiration device reduces the shell thickness of double emulsions down to 240 nm at a high throughput.

Composite Microgels Created by Complexation between Polyvinyl Alcohol and Graphene Oxide in Compressed Double‐Emulsion Drops

Small ◽  
2019 ◽  
Vol 16 (9) ◽  
pp. 1903812 ◽  
Author(s):  
Ye Hun Choi ◽  
Sang Seok Lee ◽  
Dong‐Myeong Lee ◽  
Hyeon Su Jeong ◽  
Shin‐Hyun Kim
Keyword(s):  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Double Emulsion ◽  
Emulsion Drops

Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

Soft Matter ◽  
2019 ◽  
Vol 15 (6) ◽  
pp. 1388-1395 ◽  
Author(s):  
Julie Perrotton ◽  
Rubén Ahijado-Guzmán ◽  
Lara H. Moleiro ◽  
Berta Tinao ◽  
Andrés Guerrero-Martinez ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Bilayer Membranes ◽  
Lipid Nanoparticle ◽  
Oil In Water ◽  
Emulsion Drops

Water-in-oil-in-water double emulsion drops, fabricated using capillary microfluidics, enable the formation of vesicles with hybrid lipid/nanoparticle membranes.

scholarly journals Microfluidic device for on-chip mixing and encapsulation of lysates

2018 ◽  
Author(s):  
Chang Jui-Chia ◽  
Swank Zoe ◽  
Keiser Oliver ◽  
Maerkl Sebastian ◽  
Amstad Esther
Keyword(s):  
Fluorescent Proteins ◽  
Double Emulsion ◽  
Green Fluorescent Proteins ◽  
Single Experiment ◽  
Minimal Sample ◽  
Wide Range ◽  
Pneumatic Valves ◽  
Emulsion Drops ◽  
On Chip ◽  
Green Fluorescent

AbstractEmulsion drops are often employed as picoliter-sized containers to perform screening assays. These assays usually entail the formation of drops encompassing discrete objects such as cells or microparticles and reagents to study interactions between the different encapsulants. Drops are also used to screen influences of reagent concentrations on the final product. However, these latter assays are less frequently performed because it is difficult to change the reagent concentration over a wide range with high precision within a single experiment. In this paper, we present a microfluidic double emulsion drop maker containing pneumatic valves that enable injection of different reagents using pulsed width modulation and subsequent mixing. This device can produce drops from reagent volumes as low as 10 μl with minimal sample loss, thereby enabling experiments that would be prohibitively expensive using droplet generators that do not contain valves. We employ this device to monitor the kinetics of cell free synthesis of green fluorescent proteins inside double emulsions. To demonstrate the potential of this device, we perform DNA titration experiments in double emulsion drops to test the influence of the DNA concentration on the amount of green fluorescence proteins produced.

A simple microfluidic method for one-step encapsulation of reagents with varying concentrations in double emulsion drops for nanoliter-scale reactions and analyses

2017 ◽  
Vol 9 (17) ◽  
pp. 2511-2516 ◽  
Author(s):  
Likai Hou ◽  
Yukun Ren ◽  
Yankai Jia ◽  
Xiaokang Deng ◽  
Zheng Tang ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Oil In Water ◽  
Emulsion Drops ◽  
One Step

This work reports a simple microfluidic method for one-step encapsulation of two reagents with varying concentrations in water-in-oil-in-water (W/O/W) double-emulsion drops.

Osmolarity-controlled swelling behaviors of dual-cored double-emulsion drops

2017 ◽  
Vol 21 (4) ◽  
Author(s):  
Likai Hou ◽  
Yukun Ren ◽  
Yankai Jia ◽  
Xiaoming Chen ◽  
Xiaokang Deng ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Emulsion Drops ◽  
Swelling Behaviors

scholarly journals Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions

Lab on a Chip ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 147-154 ◽  
Author(s):  
Saraf Nawar ◽  
Joshuah K. Stolaroff ◽  
Congwang Ye ◽  
Huayin Wu ◽  
Du Thai Nguyen ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Microfluidic Devices ◽  
Surface Wettability ◽  
Double Emulsions ◽  
Channel Surface ◽  
Emulsion Drops ◽  
Scalable Production

We present a multilayer dropmaker geometry that enables the modular fabrication of microfluidic devices containing precisely patterned channel surface wettability. The platform is used for the scalable production of uniform double emulsion drops.

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