Optimization of sample preparation and a quadrupole ICP-MS measurement protocol for the determination of elemental impurities in pharmaceutical substances in compliance with USP guidelines

2012 ◽  
Vol 27 (11) ◽  
pp. 1909 ◽  
Author(s):  
K. Van Hoecke ◽  
C. Catry ◽  
F. Vanhaecke
Keyword(s):  
Sample Preparation ◽  
Elemental Impurities ◽  
Pharmaceutical Substances ◽  
Icp Ms ◽  
Measurement Protocol

scholarly journals Determination of Selenium in Bovine Semen by ICP-MS Using Formic Acid for Sample Preparation

2017 ◽  
Author(s):  
Silmara Bianchi ◽  
Clarice Amaral ◽  
Caroline Silva ◽  
Ana Rita Nogueira
Keyword(s):  
Sample Preparation ◽  
Formic Acid ◽  
Bovine Semen ◽  
Icp Ms

Green and efficient sample preparation method for the determination of catalyst residues in margarine by ICP-MS

Talanta ◽  
2017 ◽  
Vol 174 ◽  
pp. 394-400 ◽  
Author(s):  
Carla Andrade Hartwig ◽  
Rodrigo Mendes Pereira ◽  
Diogo La Rosa Novo ◽  
Dirce Taina Teixeira Oliveira ◽  
Marcia Foster Mesko
Keyword(s):  
Sample Preparation ◽  
Preparation Method ◽  
Sample Preparation Method ◽  
Icp Ms

scholarly journals Germanium determination in environmental object by the method of mass spectrometry with inductively coupled plasma

2019 ◽  
Vol 85 (4) ◽  
pp. 110-113
Author(s):  
Olexandr Ponomarenko ◽  
Anatolyi Samchuk ◽  
Kateryna Vovk ◽  
Igor Shvaika ◽  
Ganna Grodzinskaya
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Inductively Coupled Plasma ◽  
Microwave Field ◽  
Antitumor Effects ◽  
Inductively Coupled ◽  
Ms Analysis ◽  
Icp Ms ◽  
Relative Standard

The analytical technologies of sample preparation of rocks and mushrooms using the microwave field for the determination of germanium by the method of mass spectrometry with inductively coupled plasma (ICP-MS analysis) have been developed. Germanium is a rare element. Germanium is homology of silicon and carbon. To date, the definition of low content of germanium in geological objects is a rather complex analytical task, which requires its concentration - extraction, co-precipitation, ion exchange. At present, the harmonious combination of the method of natural objects decomposition in the microwave field and germanium determination using ICP-MS analysis is particularly promising. Sample preparation of silicate rocks for ICP-MS determination of germanium was carried out by decomposition in a mixture of hydrofluoric, phosphate and nitric acids (5: 5: 2) in a microwave oven program at 240°C for 30 min. Sample preparation of mushrooms for ICP-MS germanium determination was carried out according to the following scheme. Initially, the dried sample was sealed in the presence of CaO, after dissolving it in a mixture of HNO3+HF+H3PO4 (6:6:1). Ge solution was extracted by Nazarenko V.A. extraction method. The developed analytical schemes have made it possible to significantly reduce the duration and labor intensity of sample preparation. The obtained solutions were analyzed using an inductively coupled plasma mass spectrometer. The developed method for determining germanium by ICP-MS analysis has been successfully tested on standard rock samples. The obtained results are in accordance with the accepted attribute, the relative standard deviation Sr ranges from 0.7-0.9. The data on the content and distribution of germanium in the Boletales fungi are obtained. They indicate wild mushrooms contain high levels of germanium, especially Boletus and Mushroom biospores. These studies are necessary because the essential properties of germanium and its compounds attract special attention of scientists today. Complementary Ge compounds which have hypotensive, bactericidal, antiviral and antitumor effects have already been synthesized.

Determination of elemental impurities of Arsenic, Cadmium, Mercury, Lead and Palladium content in Testosterone propionate by using ICP-MS

2021 ◽  
pp. 195-202
Author(s):  
Suresh P. ◽  
Konda Ravi Kumar
Keyword(s):  
Nitric Acid ◽  
Present Method ◽  
Testosterone Propionate ◽  
Rf Power ◽  
High Toxicity ◽  
Elemental Impurities ◽  
Icp Ms ◽  
Energy Discrimination ◽  
Palladium Content

The aim of the present work is to develop and establish a validated analytical method for the determination of arsenic, cadmium, mercury, lead and palladium content in testosterone propionate by using inductive coupled plasma mass spectroscopy (ICP-MS). Samples were analyzed after a preparation of sample solution by dissolving in suitable solvents of concentrated nitric acid and concentrated hydrochloric acid. In the present method, RF power of 1550 watts, RF matching is 1.80 V, nebulizer flow of 0.10 rps and plasma view at spectrum mode were used. Octopole conditions are He flow is on, He flow rate is 4.3 mL/min and energy discrimination is 3.0 V were used. Significant savings in sample volumes, reagents, analysis cost and time are realized. Arsenic, cadmium, mercury, lead and palladium are primary concerned due to their high toxicity and potential contaminants should be limited in testosterone propionate and the developed method was validated according to ICH and USP guidelines. The correlation coefficient, recovery rate, LOD and LOQ reached the acceptable limits. The validated method was selective, sensitive, rapid and capable of the determination of elemental impurities of arsenic, cadmium, mercury, lead and palladium content in bulk drugs.

Measurement uncertainty evaluation from correlated validation data: Determination of elemental impurities in pharmaceutical products by ICP-MS

Talanta ◽  
2020 ◽  
Vol 220 ◽  
pp. 121386 ◽  
Author(s):  
David Milde ◽  
Tomáš Pluháček ◽  
Martin Kuba ◽  
Jitka Součková ◽  
Ricardo J.N. Bettencourt da Silva
Keyword(s):  
Measurement Uncertainty ◽  
Pharmaceutical Products ◽  
Uncertainty Evaluation ◽  
Validation Data ◽  
Elemental Impurities ◽  
Icp Ms ◽  
Measurement Uncertainty Evaluation

Determination of total and inorganic mercury in whole blood by cold vapor inductively coupled plasma mass spectrometry (CV ICP-MS) with alkaline sample preparation

2009 ◽  
Vol 24 (10) ◽  
pp. 1414 ◽  
Author(s):  
Jairo L. Rodrigues ◽  
Daiane P. Torres ◽  
Vanessa C. de Oliveira Souza ◽  
Bruno L. Batista ◽  
Samuel S. de Souza ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Whole Blood ◽  
Inductively Coupled Plasma ◽  
Inorganic Mercury ◽  
Cold Vapor ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Optimization of Sample Preparation in the Determination of Minerals and Trace Elements in Honey by ICP-MS

2013 ◽  
Vol 7 (5) ◽  
pp. 1009-1015 ◽  
Author(s):  
Ana B. P. Leme ◽  
Silmara R. Bianchi ◽  
Renato L. Carneiro ◽  
Ana R. A. Nogueira
Keyword(s):  
Trace Elements ◽  
Sample Preparation ◽  
Icp Ms ◽  
Minerals And Trace Elements
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