A customizable, low-power, wireless, embedded sensing platform for resistive nanoscale sensors

Customizable, portable, battery-operated, wireless platforms for interfacing high-sensitivity nanoscale sensors are a means to improve spatiotemporal measurement coverage of physical parameters. Such a platform can enable the expansion of IoT for environmental and lifestyle applications. Here we report a platform capable of acquiring currents ranging from 1.5 nA to 7.2 µA full-scale with 20-bit resolution and variable sampling rates of up to 3.125 kSPS. In addition, it features a bipolar voltage programmable in the range of −10 V to +5 V with a 3.65 mV resolution. A Finite State Machine steers the system by executing a set of embedded functions. The FSM allows for dynamic, customized adjustments of the nanosensor bias, including elevated bias schemes for self-heating, measurement range, bandwidth, sampling rate, and measurement time intervals. Furthermore, it enables data logging on external memory (SD card) and data transmission over a Bluetooth low energy connection. The average power consumption of the platform is 64.5 mW for a measurement protocol of three samples per second, including a BLE advertisement of a 0 dBm transmission power. A state-of-the-art (SoA) application of the platform performance using a CNT nanosensor, exposed to NO2 gas concentrations from 200 ppb down to 1 ppb, has been demonstrated. Although sensor signals are measured for NO2 concentrations of 1 ppb, the 3σ limit of detection (LOD) of 23 ppb is determined (1σ: 7 ppb) in slope detection mode, including the sensor signal variations in repeated measurements. The platform’s wide current range and high versatility make it suitable for signal acquisition from resistive nanosensors such as silicon nanowires, carbon nanotubes, graphene, and other 2D materials. Along with its overall low power consumption, the proposed platform is highly suitable for various sensing applications within the context of IoT.

Outdoor Radon as a Tool to Estimate Radon Priority Areas—A Literature Overview

Doses from the exposure to outdoor radon are typically an order of magnitude smaller than those from indoor radon, causing a greater interest on investigation of the latter for radiation protection issues. As a consequence, assessment of radon priority areas (RPA) is mainly based on indoor radon measurements. Outdoor radon measurements might be needed to guarantee a complete estimation of radiological risk and may help to improve the estimation of RPA. Therefore, authors have analysed the available literature on outdoor radon to give an overview of outdoor radon surveys and potential correlation with indoor radon and estimation of RPA. The review has shown that outdoor radon surveys were performed at much smaller scale compared to indoor radon. Only a few outdoor radon maps were produced, with a much smaller density, covering a larger area, and therefore putting doubt on the representativeness of this data. Due to a large variety of techniques used for outdoor radon measurements and requirement to have detectors with a high sensitivity and resistance to harsh environmental conditions, a standardised measurement protocol should be derived. This is no simple endeavour since there are more applications in different scientific disciplines for outdoor radon measurements compared to indoor radon.

Continuous gaussian measurements of the free boson CFT: A model for exactly solvable and detectable measurement-induced dynamics

Hybrid evolution protocols, composed of unitary dynamics and repeated, weak or projective measurements, give rise to new, intriguing quantum phenomena, including entanglement phase transitions and unconventional conformal invariance. Defying the complications imposed by the non-linear and stochastic nature of the measurement process, we introduce a scenario of measurement-induced many body evolution, which possesses an exact analytical solution: bosonic Gaussian measurements. The evolution features a competition between the continuous observation of linear boson operators and a free Hamiltonian, and it is characterized by a unique and exactly solvable covariance matrix. Within this framework, we then consider an elementary model for quantum criticality, the free boson conformal field theory, and investigate in which way criticality is modified under measurements. Depending on the measurement protocol, we distinguish three fundamental scenarios (a) enriched quantum criticality, characterized by a logarithmic entanglement growth with a floating prefactor, or the loss of criticality, indicated by an entanglement growth with either (b) an area-law or (c) a volume-law. For each scenario, we discuss the impact of imperfect measurements, which reduce the purity of the wavefunction and are equivalent to Markovian decoherence, and present a set of observables, e.g., real-space correlations, the relaxation time, and the entanglement structure, to classify the measurement-induced dynamics for both pure and mixed states. Finally, we present an experimental tomography scheme, which grants access to the density operator of the system by using the continuous measurement record only.

Identification of COM Controller of a Human in Stance Based on Motion Measurement and Phase-Space Analysis

This article proposes a process to identify the standing stabilizer, namely, the controller in humans to keep upright posture stable against perturbations. We model the controller as a piecewise-linear feedback system, where the state of the center of mass (COM) is regulated by coordinating the whole body so as to locate the zero-moment point (ZMP) at the desired position. This was developed for humanoid robots and is possibly able to elaborate the fundamental control scheme used by humans to stabilize themselves. Difficulties lie on how to collect motion trajectories in a wide area of the state space for reliable identification and how to identify the piecewise-affine dynamical system. For the former problem, a motion measurement protocol is devised based on the theoretical phase portrait of the system. Regarding the latter problem, some clustering techniques including K-means method and EM (Expectation-and-Maximization) algorithm were examined. We found that a modified K-means method produced the most accurate result in this study. The method was applied to the identification of a lateral standing controller of a human subject. The result of the identification quantitatively supported a hypothesis that the COM-ZMP regulator reasonably models the human’s controller when deviations of the angular momentum about the COM are limited.

Pain fingerprinting using multimodal sensing: pilot study

Pain is a complex phenomenon, the experience of which varies widely across individuals. At worst, chronic pain can lead to anxiety and depression. Cost-effective strategies are urgently needed to improve the treatment of pain, and thus we propose a novel home-based pain measurement system for the longitudinal monitoring of pain experience and variation in different patients with chronic low back pain. The autonomous nervous system and audio-visual features are analyzed from heart rate signals, voice characteristics and facial expressions using a unique measurement protocol. Self-reporting is utilized for the follow-up of changes in pain intensity, induced by well-designed physical maneuvers, and for studying the consecutive trends in pain. We describe the study protocol, including hospital measurements and questionnaires and the implementation of the home measurement devices. We also present different methods for analyzing the multimodal data: electroencephalography, audio, video and heart rate. Our intention is to provide new insights using technical methodologies that will be beneficial in the future not only for patients with low back pain but also patients suffering from any chronic pain.

A Custom-Made Lower Limb Dynamometer for Assessing Ankle Joint Torque in Humans: Calibration and Measurement Procedures

Custom-made dynamometry was shown to objectively analyze human muscle strength around the ankle joint with accuracy, easy portability and low costs. This paper describes the full method of calibration and measurement setup and the measurement procedure when capturing ankle torque for establishing reliability of a portable custom-built electronic dynamometer. After considering the load cell offset voltage, the pivotal position was determined, and calibration with loads followed. Linear regression was used for calculating the proportionality constant between torque and measured voltage. Digital means were used for data collection and processing. Four healthy consenting participants were enrolled in the study. Three consecutive maximum voluntary isometric contractions of five seconds each were registered for both feet during plantar flexion/dorsiflexion, and ankle torque was then calculated for three ankle inclinations. A calibration procedure resulted, comprising determination of the pivotal axis and pedal constant. Using the obtained data, a measurement procedure was proposed. Obtained contraction time graphs led to easier filtering of the results. When calculating the interclass correlation, the portable apparatus demonstrated to be reliable when measuring ankle torque. When a custom-made dynamometer was used for capturing ankle torque, accuracy of the method was assured by a rigorous calibration and measurement protocol elaboration.

Limitations of Muscle Ultrasound Shear Wave Elastography for Clinical Routine—Positioning and Muscle Selection

Shear wave elastography (SWE) is a clinical ultrasound imaging modality that enables non-invasive estimation of tissue elasticity. However, various methodological factors—such as vendor-specific implementations of SWE, mechanical anisotropy of tissue, varying anatomical position of muscle and changes in elasticity due to passive muscle stretch—can confound muscle SWE measurements and increase their variability. A measurement protocol with a low variability of reference measurements in healthy subjects is desirable to facilitate diagnostic conclusions on an individual-patient level. Here, we present data from 52 healthy volunteers in the areas of: (1) Characterizing different limb and truncal muscles in terms of inter-subject variability of SWE measurements. Superficial muscles with little pennation, such as biceps brachii, exhibit the lowest variability whereas paravertebral muscles show the highest. (2) Comparing two protocols with different limb positioning in a trade-off between examination convenience and SWE measurement variability. Repositioning to achieve low passive extension of each muscle results in the lowest SWE variability. (3) Providing SWE shear wave velocity (SWV) reference values for a specific ultrasound machine/transducer setup (Canon Aplio i800, 18 MHz probe) for a number of muscles and two positioning protocols. We argue that methodological issues limit the current clinical applicability of muscle SWE.

Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia

The successful management of cervical intraepithelial neoplasia (CIN) with proper screening and treatment methods could prevent cervical cancer progression. We propose a bioimpedance spectroscopic measurement device and a multi-electrode probe as an independent screening tool for CIN. To evaluate the performance of this screening method, we enrolled 123 patients, including 69 patients with suspected CIN and 54 control patients without cervical dysplasia who underwent a hysterectomy for benign disease (non-CIN). Following conization, the electrical properties of the excised cervical tissue were characterized using an electrical bioimpedance spectroscopy-based multi-electrode probe. Twenty-eight multifrequency voltages were collected through the two concentric array electrodes via a sensitivity-optimized measurement protocol based on an electrical energy concentration method. The electrical properties of the CIN and non-CIN groups were compared with the results of the pathology reports. Reconstructed resistivity tended to decrease in the CIN and non-CIN groups as frequency increased. Reconstructed resistivity from 625 Hz to 50 kHz differed significantly between the CIN and non-CIN groups (p < 0.001). Using 100 kHz as the reference, the difference between the CIN and non-CIN groups was significant. Based on the difference in reconstructed resistivity between 100 kHz and the other frequencies, this method had a sensitivity of 94.3%, a specificity of 84%, and an accuracy of 90% in CIN screening. The feasibility of noninvasive CIN screening was confirmed through the difference in the frequency spectra evaluated in the excised tissue using the electrical bioimpedance spectroscopy-based multi-electrode screening probe.

Spatial network conduction in carbon nanotube and Ag-Ag₂S-Ag atomic switch network device platforms

<p>Networks of nanomaterials sit at a confluence of desirable features for the fabrication of advanced electronic devices, including facile fabrication, high conducting element density, and novel electrical characteristics. The spatial conduction through carbon nanotube (CNT) and Ag-Ag₂S-Ag atomic switch networks was investigated to determine how better to implement them in novel sensing and computation device platforms. Selective gating of localized regions of CNT networks with varying densities was investigated. To achieve this, lithographically defined FET structures were developed that allowed gating of localised regions of the CNT FET network area. The CNT FET device sensitivity to gating of different regions of the CNT network was measured for devices with network densities close to the percolation threshold. A 10² increase in sensitivity to local gating for CNT FET devices with low network densities was observed compared with high-density CNT networks. Networks densities were all well below a density where metallic shorts could be present, so the trends observed were attributed to m-s junction dominated gating of the network. A better understanding of the dominant conduction in CNT network FETs at low network densities is important for tuning their properties for use as novel biosensing platforms or a tunable connectivity conducting film. A CNT network simulation was developed to test the effects of local gating on networks of bundled CNTs with varying densities. Up to 70,000 bundles on a 60 µm x 60 µm simulated network area were used to generate an electrical network of field sensitive elements where the gate field could be spatially modified to investigate the effect of local gating. Monte Carlo methods were used to simulate large numbers of random networks with m-s junctions as the dominant gate-dependent element. Networks with 13.5% metallic bundles were shown to exhibit trends in local gating similar to the experimental systems. Current density maps showed key conduction paths in low-density devices, which supports a model of m-s junction dominance to explain the local and global gate responses measured in experimental CNT FET systems. Prototype Ag-Ag₂S-Ag atomic switch networks (ASN) device were fabricated using spray-coated silver nanowires which were sulfurised using gas-phase sulfur after deposition. Electrical formation of memristive junctions and hysteretic switching curves were shown under swept voltage bias demonstrating memristive behaviour. ASN devices have been demonstrated to show critical dynamics and memristive characteristics due to the complex connection of atomic switches formed at Ag-Ag₂S-Ag junctions between wires. A fabrication and measurement protocol for ASN based neuromorphic devices on multi-electrode array (MEA) platforms was developed. The electrical measurement system was designed and deployed to facilitate time-resolved measurement across multiple channels simultaneously on those MEA platforms. Under DC bias, MEA-based ASN devices showed switching events with a power-law distribution over two orders of magnitude of conductance changes and time intervals consistent with self-organized criticality within the network. The dynamic response of the critical system was measured across the network area. Changes in the relative voltage across the ASN network area were observed using 16 channel MEA platforms, showing spatiotemporal variation in voltage across the network. Novel application of principal component analysis to ASNswas used to demonstrate reduction of dimension while preserving relative voltage changes. This paves the way for scalable analysis of the complex dynamic signals from critical ASN systems.</p>