Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

MedChemComm ◽  
2013 ◽  
Vol 4 (1) ◽  
pp. 95-100 ◽  
Author(s):  
James S. Scott ◽  
Alan M. Birch ◽  
Katy J. Brocklehurst ◽  
Hayley S. Brown ◽  
Kristin Goldberg ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
G Protein ◽  
Aqueous Solubility ◽  
G Protein Coupled Receptor ◽  
Hydrogen Bond Acceptor ◽  
G Protein Coupled

Solubility improvements in a series of GPR119 agonists are achieved through reduction of lipophilicity together with hydrogen bond acceptor modulation.

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled

Involvement of the constitutive activity of the GHS-R1a (ghrelin G-protein coupled receptor) in the tumorigenesis of somatotroph adenomas

2013 ◽  
Author(s):  
Yves Louis Mear ◽  
Xavier Come Donato ◽  
Marie Pierre Blanchard ◽  
Celine Defilles ◽  
Christophe Lisbonis ◽  
...  
Keyword(s):  
G Protein ◽  
Constitutive Activity ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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