Simultaneous analysis of dopamine and homovanillic acid by high-performance liquid chromatography with wall-jet/thin-layer electrochemical detection

The Analyst ◽  
2013 ◽  
Vol 138 (23) ◽  
pp. 7246 ◽  
Author(s):  
Yaping Zhou ◽  
Hongling Yan ◽  
Qingji Xie ◽  
Siyu Huang ◽  
Jiali Liu ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Thin Layer ◽  
Electrochemical Detection ◽  
High Performance ◽  
Homovanillic Acid ◽  
Simultaneous Analysis ◽  
Wall Jet

Determination of vanillylmandelic acid, vanillactic acid, and homovanillic acid in dried urine on filter-paper discs by high-performance liquid chromatography with coulometric electrochemical detection for neuroblastoma screening.

1988 ◽  
Vol 34 (11) ◽  
pp. 2228-2230 ◽  
Author(s):  
Y Kinoshita ◽  
S Yamada ◽  
K Haraguchi ◽  
T Takayanagi ◽  
Y Mori ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Electrochemical Detection ◽  
Filter Paper ◽  
High Performance ◽  
Homovanillic Acid ◽  
Vanillylmandelic Acid ◽  
Chromatographic Procedure ◽  
One Year

Abstract We report a method for determination of vanillylmandelic acid, vanillactic acid, and homovanillic acid by high-performance liquid chromatography (HPLC), with coulometric electrochemical detection, for mass screening of neuroblastoma. Urine samples were collected on filter paper, dried, and then pretreated. The chromatographic procedure is reliable and fast, allowing for a large sample throughput for routine screening. Intricate extraction procedures and centrifugal separation are unnecessary. Screening for neuroblastoma by HPLC is rapidly gaining acceptance in Japan, and our method is being used at many screening centers. Of 26,571 infants screened in one year in Yokohama City, our method detected five with neuroblastoma.

scholarly journals Reference Values for Urinary HMMA, HVA, Noradrenaline, Adrenaline, and Dopamine Excretion in Children Using Random Urine Samples and HPLC with Electrochemical Detection

1992 ◽  
Vol 29 (4) ◽  
pp. 400-404 ◽  
Author(s):  
M Fitzgibbon ◽  
R J FitzGerald ◽  
W P Tormey ◽  
A O'Meara ◽  
D Kenny
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Electrochemical Detection ◽  
High Performance ◽  
Homovanillic Acid ◽  
Urine Samples ◽  
Age Group ◽  
Creatinine Concentration ◽  
Urinary Creatinine ◽  
Reference Limits

Random urine samples were collected from 305 children aged from birth to 14 years and the values of hydroxymethoxymandelic acid, homovanillic acid, noradrenaline, adrenaline, and dopamine were measured by high-performance liquid chromatography with electrochemical detection. The results were reported relative to the urinary creatinine concentration and the values declined progressively with increasing age for each analyte with the exception of adrenaline. The results for each age group were not normally distributed and all values except outliers were retained in determining the upper reference limits.

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