Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

2013 ◽  
Vol 5 (16) ◽  
pp. 3799 ◽  
Author(s):  
Robert W. Smith ◽  
James C. Reynolds ◽  
Sze-Ling Lee ◽  
Colin S. Creaser
Keyword(s):  
Mass Spectrometry ◽  
Thermal Desorption ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Direct Analysis ◽  
Asymmetric Waveform ◽  
Genotoxic Impurities

scholarly journals Rapid determination of N-methylpyrrolidine in cefepime by combining direct infusion electrospray ionisation-time-of-flight mass spectrometry with field asymmetric waveform ion mobility spectrometry

2015 ◽  
Vol 7 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Robert W. Smith ◽  
Lisa B. Cox ◽  
Aswandi Yudin ◽  
James C. Reynolds ◽  
Mark Powell ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Rapid Determination ◽  
Time Of Flight ◽  
Asymmetric Waveform ◽  
Direct Infusion ◽  
Electrospray Ionisation ◽  
Flight Mass Spectrometry

FAIMS separation prior to mass spectrometry enables selective transmission of NMP in cefepime without interference from NMP formed by in-source CID.

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