Fortification of blood plasma from cancer patients with human serum albumin decreases the concentration of cisplatin-derived toxic hydrolysis products in vitro

Metallomics ◽  
2014 ◽  
Vol 6 (11) ◽  
pp. 2034-2041 ◽  
Author(s):  
Thomas T. Morris ◽  
Yibing Ruan ◽  
Victor A. Lewis ◽  
Aru Narendran ◽  
Jürgen Gailer
Keyword(s):  
Side Effects ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Cancer Patients ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Hydrolysis Products ◽  
Human Serum Albumin Concentration

Boosting the human serum albumin concentration in cancer patients is suggested to be a feasible strategy to possibly reduce the severe toxic side-effects of cisplatin.

Measurement of human serum albumin concentration using Raman spectroscopy setup

2016 ◽  
Vol 48 (6) ◽  
Author(s):  
Dmitry N. Artemyev ◽  
Valery P. Zakharov ◽  
Igor L. Davydkin ◽  
Julia A. Khristoforova ◽  
Anastasia A. Lykina ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Human Serum Albumin Concentration

A rapid paper-based detection system for determination of human serum albumin concentration

2018 ◽  
Vol 352 ◽  
pp. 241-246 ◽  
Author(s):  
Ruey-Jen Yang ◽  
Chin-Chung Tseng ◽  
Wei-Jhong Ju ◽  
Hsiang-Li Wang ◽  
Lung-Ming Fu
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Detection System ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Human Serum Albumin Concentration

Nof2206Probing the interaction of memantine, an important Alzheimer's drug, with human serum albumin: In silico and In vitro approach

2021 ◽  
pp. 116888
Author(s):  
Fahad A. Alhumaydhi ◽  
Mohammad Abdullah Aljasir ◽  
Abdullah S.M. Aljohani ◽  
Suliman A. Alsagaby ◽  
Ameen S.S. Alwashmi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Silico

scholarly journals Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

2020 ◽  
Vol 14 (1) ◽  
pp. 22
Author(s):  
Kenji Tsukigawa ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
Koji Nishi ◽  
Toshihiko Tsutsumi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Coupling Reaction ◽  
Synthetic Polymer ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Polymer Conjugate ◽  
Acidic Conditions

In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Human serum albumin (HSA), which has a high biocompatibility and good biodegradability, is also a potent carrier for delivering antitumor drugs. The objective of this study was to develop pH-sensitive HSA conjugates of THP (HSA-THP), and investigate the release of THP and the cytotoxicity under acidic conditions in vitro for further clinical development. HSA-THP was synthesized by conjugating maleimide hydrazone derivatives of THP with poly-thiolated HSA using 2-iminothiolane, via a thiol-maleimide coupling reaction. We synthesized two types of HSA-THP that contained different amounts of THP (HSA-THP2 and HSA-THP4). Free THP was released from both of the HSA conjugates more rapidly at an acidic pH, and the rates of release for HSA-THP2 and HSA-THP4 were similar. Moreover, both HSA-THPs exhibited a higher cytotoxicity at acidic pH than at neutral pH, which is consistent with the effective liberation of free THP under acidic conditions. These findings suggest that these types of HSA-THPs are promising candidates for further development.

The in Vitro Anti-HIV Efficacy of Negatively Charged Human Serum Albumin Is Antagonized by Heparin

1997 ◽  
Vol 13 (8) ◽  
pp. 677-683 ◽  
Author(s):  
P.J. SWART ◽  
C.S. SUN ◽  
M.E. KUIPERS ◽  
C. ASUNCION ◽  
S. JOSEPHS ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Anti Hiv
Sign in / Sign up

Export Citation Format

Share Document