scholarly journals Hybrid periodic mesoporous organosilica designed to improve the properties of immobilized enzymes

RSC Advances ◽  
2014 ◽  
Vol 4 (65) ◽  
pp. 34356-34368 ◽  
Author(s):  
V. Gascón ◽  
I. Díaz ◽  
R. M. Blanco ◽  
C. Márquez-Álvarez
Keyword(s):  
Organic Solvent ◽  
Pore Size ◽  
High Stability ◽  
Immobilized Enzymes ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Solvent Systems

Hybrid organosilica supports synthesized with pore size adjusted to enzyme dimensions provide high stability in organic solvent systems and prevent leaching.

scholarly journals Bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica nanoparticles: a promising nanocarrier for delivery of Cas9-sgRNA ribonucleoproteine

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Pardis Rahimi Salekdeh ◽  
Leila Ma’mani ◽  
Javad Tavakkoly-Bazzaz ◽  
Hossein Mousavi ◽  
Mohammad Hossein Modarressi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
High Stability ◽  
Gene Editing ◽  
Nitrogen Adsorption ◽  
Attenuated Total Reflectance ◽  
Periodic Mesoporous Organosilica ◽  
Total Reflectance ◽  
X Ray ◽  
Mesoporous Organosilica

Abstract Background There is a great interest in the efficient intracellular delivery of Cas9-sgRNA ribonucleoprotein complex (RNP) and its possible applications for in vivo CRISPR-based gene editing. In this study, a nanoporous mediated gene-editing approach has been successfully performed using a bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica (PMO) nanoparticles (RNP@AGu@PEG1500-PMO) as a potent and biocompatible nanocarrier for RNP delivery. Results The bi-functionalized MSN-based nanomaterials have been fully characterized using electron microscopy (TEM and SEM), nitrogen adsorption measurements, thermogravimetric analysis (TGA), X-ray powder diffraction (XRD), Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), and dynamic light scattering (DLS). The results confirm that AGu@PEG1500-PMO can be applied for gene-editing with an efficiency of about 40% as measured by GFP gene knockdown of HT1080-GFP cells with no notable change in the morphology of the cells. Conclusions Due to the high stability and biocompatibility, simple synthesis, and cost-effectiveness, the developed bi-functionalized PMO-based nano-network introduces a tailored nanocarrier that has remarkable potential as a promising trajectory for biomedical and RNP delivery applications.

Light-harvesting photocatalysis for H2 evolution by methylacridone-bridged periodic mesoporous organosilica

2021 ◽  
Vol 287 ◽  
pp. 119965
Author(s):  
Yasutomo Goto ◽  
Ken-ichi Yamanaka ◽  
Masataka Ohashi ◽  
Yoshifumi Maegawa ◽  
Shinji Inagaki
Keyword(s):  
Light Harvesting ◽  
H2 Evolution ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica

Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions

2019 ◽  
Vol 30 (4) ◽  
pp. 929-932 ◽  
Author(s):  
Xiaodan Su ◽  
Jun Tao ◽  
Qing Wang ◽  
Peng Xu ◽  
Wei Luo ◽  
...  
Keyword(s):  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica

Chemical sensors based on nano-sized lanthanide-grafted periodic mesoporous organosilica hybrid materials

2019 ◽  
Vol 7 (26) ◽  
pp. 8109-8119 ◽  
Author(s):  
Anna M. Kaczmarek ◽  
Pascal Van Der Voort
Keyword(s):  
Hybrid Materials ◽  
Chemical Sensors ◽  
Aprotic Solvent ◽  
Periodic Mesoporous Organosilica ◽  
Ion Sensing ◽  
Mesoporous Organosilica

Nano-sized PMOs grafted with lanthanides show selective ion sensing for Pb2+ and Cr3+ and strong solvatochromism allowing their use as protic and aprotic solvent sensors.

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