Multicomponent synthesis of pyridines via diamine functionalized mesoporous ZrO2 domino intramolecular tandem Michael type addition

A new and straightforward synthetic method was developed for the facile synthesis of heterocycle-fused pyridine derivatives in aqueous media from Knoevenagel condensation between an aromatic aldehyde and an active methylene compound.

Download Full-text

Green synthesis of pyranopyrazoles via biocatalytic one-pot Knoevenagel condensation–Michael-type addition–heterocyclization cascade in non-aqueous media

Research on Chemical Intermediates ◽

10.1007/s11164-020-04122-x ◽

2020 ◽

Vol 46 (5) ◽

pp. 2805-2816

Author(s):

Prabhakar Shrivas ◽

Rajat Pandey ◽

Sangesh Zodape ◽

Atul Wankhade ◽

Umesh Pratap

Keyword(s):

Green Synthesis ◽

Knoevenagel Condensation ◽

Aqueous Media ◽

One Pot ◽

Michael Type Addition

Download Full-text

A solvent free approach for Knoevenagel condensation: facile synthesis of 3-cyano and 3-carbethoxycoumarins

Green Processing and Synthesis ◽

10.1515/gps-2013-0114 ◽

2014 ◽

Vol 3 (3) ◽

Author(s):

Suresh Kumar

Keyword(s):

Knoevenagel Condensation ◽

Aromatic Aldehydes ◽

Solvent Free ◽

Efficient Synthesis ◽

Facile Synthesis ◽

Basic Alumina ◽

Active Methylene Compounds ◽

Active Methylene

AbstractA simple, efficient and solvent free approach for the Knoevenagel condensation has been developed which involves grinding of active methylene compounds with aromatic aldehydes over basic alumina. Using this solvent free Knoevenagel approach, a facile and efficient synthesis of 3-cyano and 3-carbethoxycoumarins has also been developed, which involves the grinding of 2-hydroxybenzaldehydes with malononitrile or ethylcyanoacetate respectively over basic alumina followed by grinding with p-toluenesulphonic acid (PTSA) in the same mortar.

Download Full-text

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

JOURNAL OF ADVANCES IN CHEMISTRY ◽

10.24297/jac.v12i1.845 ◽

2015 ◽

Vol 12 (1) ◽

pp. 3910-3918 ◽

Cited By ~ 1

Author(s):

Dr Remon M Zaki ◽

Prof Adel M. Kamal El-Dean ◽

Dr Nermin A Marzouk ◽

Prof Jehan A Micky ◽

Mrs Rasha H Ahmed

Keyword(s):

Biological Activity ◽

Carbonyl Compounds ◽

Mass Spectra ◽

The Other ◽

Pyridine Derivatives ◽

Facile Synthesis ◽

High Biological Activity ◽

Basic Hydrolysis ◽

Pyridine Carboxylate ◽

Hydrolysis Of

Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Download Full-text

Novel multicomponent synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives

Chemistry of Heterocyclic Compounds ◽

10.1007/s10593-020-02854-7 ◽

2020 ◽

Vol 56 (12) ◽

pp. 1592-1598

Author(s):

Ivan V. Dyachenko ◽

Vladimir D. Dyachenko ◽

Pavel V. Dorovatovskii ◽

Victor N. Khrustalev ◽

Valentine G. Nenajdenko

Keyword(s):

Pyridine Derivatives ◽

Multicomponent Synthesis

Download Full-text

ChemInform Abstract: A Facile Synthesis of Pyrazolo(1,5-a)pyridine Derivatives: Reaction of Cinnamonitriles with 5-Amino-4-cyano-3-cyanomethylpyrazole.

ChemInform ◽

10.1002/chin.198908189 ◽

1989 ◽

Vol 20 (8) ◽

Author(s):

A. H. H. ELGHANDOUR ◽

M. R. H. ELMOGHAYAR ◽

M. M. M. RAMIZ

Keyword(s):

Pyridine Derivatives ◽

Facile Synthesis

Download Full-text

Synthesis of β- and β,β-substituted Morita–Baylis–Hillman adducts using a two-step protocol

Canadian Journal of Chemistry ◽

10.1139/v2012-017 ◽

2012 ◽

Vol 90 (5) ◽

pp. 450-463 ◽

Cited By ~ 8

Author(s):

David I. Magee ◽

Same Ratshonka ◽

Jessica McConaghy ◽

Maggie Hood

Keyword(s):

Knoevenagel Condensation ◽

Condensation Reaction ◽

Facile Synthesis ◽

Aliphatic Aldehydes ◽

Tert Butyl ◽

Keto Esters ◽

Knoevenagel Condensation Reaction

The synthesis of a large number of β- and β,β-substituted keto esters was successful by the use of the Knoevenagel condensation reaction. The stereoselectivity of these reactions was improved by alteration of various substituent groups. Although there were few examples of complete Z selectivity, the use of tert-butyl acetoacetate with either aromatic or aliphatic aldehydes afforded Z selectivity. The selective reductions of these substituted keto esters was successfully achieved by using a combination of NaBH4 and CeCl3·7H2O or Yb(OTf)3, which allowed a facile synthesis of a large number of stereochemically pure substituted Morita–Baylis–Hillman adducts, including β,β-substituted adducts.

Download Full-text