scholarly journals A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action

MedChemComm ◽  
2016 ◽  
Vol 7 (3) ◽  
pp. 464-470 ◽  
Author(s):  
Andreas S. Madsen ◽  
Christian A. Olsen
Keyword(s):  
Histone Deacetylase ◽  
Mechanism Of Action ◽  
Histone Deacetylase Inhibitor ◽  
Hdac Inhibitors ◽  
Zinc Binding ◽  
Kinetic Evaluation ◽  
Deacetylase Inhibitor ◽  
Dependent Mechanism

Kinetic evaluation of HDAC inhibitors containing different zinc-binding chemotypes demonstrates that trifluoromethyl ketone-containing compounds can inhibit individual HDAC isozymes via differential mechanisms.

scholarly journals Possible reactivation of chromosomally integrated human herpesvirus 6 after treatment with histone deacetylase inhibitor

2018 ◽  
Vol 2 (12) ◽  
pp. 1367-1370 ◽  
Author(s):  
Ioannis Politikos ◽  
Malgorzata McMasters ◽  
Christine Bryke ◽  
David Avigan ◽  
Vassiliki A. Boussiotis
Keyword(s):  
Viral Load ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Hdac Inhibitors ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Deacetylase Inhibitor ◽  
Key Points ◽  
Herpesvirus 6

Key Points HDAC inhibitors might induce ciHHV-6 reactivation. In ciHHV-6 HSCT recipients posttransplant viral load can estimate persistent host chimerism when the donor is ciHHV-6 negative.

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