Depsipeptide (FK228) as a Novel Histone Deacetylase Inhibitor: Mechanism of Action and Anticancer Activity

2007 ◽  
Vol 7 (10) ◽  
pp. 1062-1069 ◽  
Author(s):  
Ewa Lech-Maranda ◽  
Ewa Robak ◽  
Anna Korycka ◽  
Tadeusz Robak
Keyword(s):  
Anticancer Activity ◽  
Histone Deacetylase ◽  
Mechanism Of Action ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

scholarly journals A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action

MedChemComm ◽  
2016 ◽  
Vol 7 (3) ◽  
pp. 464-470 ◽  
Author(s):  
Andreas S. Madsen ◽  
Christian A. Olsen
Keyword(s):  
Histone Deacetylase ◽  
Mechanism Of Action ◽  
Histone Deacetylase Inhibitor ◽  
Hdac Inhibitors ◽  
Zinc Binding ◽  
Kinetic Evaluation ◽  
Deacetylase Inhibitor ◽  
Dependent Mechanism

Kinetic evaluation of HDAC inhibitors containing different zinc-binding chemotypes demonstrates that trifluoromethyl ketone-containing compounds can inhibit individual HDAC isozymes via differential mechanisms.

Valuable Insight into the Anticancer Activity of the Platinum-Histone Deacetylase Inhibitor Conjugate, cis-[Pt(NH3)2malSAHA–2H)]

2012 ◽  
Vol 9 (7) ◽  
pp. 1990-1999 ◽  
Author(s):  
Viktor Brabec ◽  
Darren M. Griffith ◽  
Anna Kisova ◽  
Hana Kostrhunova ◽  
Lenka Zerzankova ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Valuable Insight ◽  
Deacetylase Inhibitor ◽  
Insight Into
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