New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5

2015 ◽  
Vol 13 (23) ◽  
pp. 6511-6521 ◽  
Author(s):  
Olivier-Mohamad Soueidan ◽  
Brendan J. Trayner ◽  
Tina N. Grant ◽  
Jeff R. Henderson ◽  
Frank Wuest ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Binding Site ◽  
Tumor Cells ◽  
Hexose Transporter ◽  
Transporter Protein ◽  
High Affinity ◽  
Cells In Culture ◽  
Molecular Imaging Probes ◽  
Imaging Probes

Two fluorinated fructose analogs are taken up by tumor cells in culture. Their high affinity for the transporter protein GLUT5 provides information on the structural demands of its binding site, and suggests approaches towards new molecular imaging probes.

Can we accurately quantify nanoparticle associated proteins when constructing high-affinity MRI molecular imaging probes?

2011 ◽  
Vol 6 (3) ◽  
pp. 119-125 ◽  
Author(s):  
Gabriella Rimkus ◽  
Sibylle Bremer-Streck ◽  
Cordula Grüttner ◽  
Werner Alois Kaiser ◽  
Ingrid Hilger
Keyword(s):  
Molecular Imaging ◽  
High Affinity ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Associated Proteins

Functional MOFs as molecular imaging probes and theranostics

2020 ◽  
pp. 425-443
Author(s):  
Rajasekharreddy Pala ◽  
Subhaswaraj Pattnaik ◽  
Yun Zeng ◽  
Siddhardha Busi ◽  
Surya M. Nauli ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes

scholarly journals Techniques for Molecular Imaging Probe Design

2011 ◽  
Vol 10 (6) ◽  
pp. 7290.2011.00003 ◽  
Author(s):  
Fred Reynolds ◽  
Kimberly A. Kelly
Keyword(s):  
Molecular Imaging ◽  
Target Selection ◽  
Relevant Information ◽  
Probe Design ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Genomics And Proteomics ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Underlying Mechanisms

Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology—all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.

Preparation and comparative evaluation of 99m Tc-HYNIC-cNGR and 99m Tc-HYNIC-PEG2 -cNGR as tumor-targeting molecular imaging probes

2018 ◽  
Vol 61 (2) ◽  
pp. 68-76 ◽  
Author(s):  
Kusum Vats ◽  
Drishty Satpati ◽  
Rohit Sharma ◽  
Chandan Kumar ◽  
Haladhar Dev Sarma ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Comparative Evaluation ◽  
Tumor Targeting ◽  
Molecular Imaging Probes ◽  
Imaging Probes

Recent Progress of Molecular Imaging Probes Based on Gadofullerenes

2012 ◽  
Vol 40 (10) ◽  
pp. 1607-1615 ◽  
Author(s):  
Jun-Peng ZHENG ◽  
Ming-Ming ZHEN ◽  
Chun-Ru WANG ◽  
Chun-Ying SHU
Keyword(s):  
Molecular Imaging ◽  
Recent Progress ◽  
Molecular Imaging Probes ◽  
Imaging Probes

Surface modification: how nanoparticles assemble to molecular imaging probes

2013 ◽  
Vol 15 (12) ◽  
Author(s):  
Huilong Tan ◽  
Lun Yu ◽  
Feng Gao ◽  
Weihua Liao ◽  
Wei Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes
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