Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-l-fucose biosynthetic enzymes

2016 ◽  
Vol 14 (6) ◽  
pp. 1988-2006 ◽  
Author(s):  
Hsien-Tai Chiu ◽  
Chien-Pao Weng ◽  
Yu-Chin Lin ◽  
Kuan-Hung Chen

From Nocardia was cloned and functionally characterized a giant gene cluster for biosyntheses of brasilinolides as potent immunosuppressive and anticancer agents.

2004 ◽  
Vol 39 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Takamitsu Sakai ◽  
Kinya Kanai ◽  
Kiyoshi Osatomi ◽  
Kazuma Yoshikoshi

2019 ◽  
Vol 17 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Taro Shiraishi ◽  
Makoto Nishiyama ◽  
Tomohisa Kuzuyama

The biosynthetic pathway of the uridine-derived nucleoside antibiotic A-94964 was proposed via in silico analysis coupled with gene deletion experiments.


ChemBioChem ◽  
2011 ◽  
Vol 12 (9) ◽  
pp. 1411-1416 ◽  
Author(s):  
Niña Socorro Cortina ◽  
Ole Revermann ◽  
Daniel Krug ◽  
Rolf Müller

2017 ◽  
Vol 103 ◽  
pp. 25-33 ◽  
Author(s):  
Ying Wang ◽  
Pengjie Hu ◽  
Yuanyuan Pan ◽  
Yaxin Zhu ◽  
Xingzhong Liu ◽  
...  

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