Novel highly aligned, double-layered, hollow fibrous polycarbonate membranes with a perfectly tightly packed pentagonal pore structure fabricated using the electrospinning process

RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 88857-88865 ◽  
Author(s):  
Yun-Shao Huang ◽  
Chi-Ching Kuo ◽  
Chun-Chun Huang ◽  
Shin-Cheng Jang ◽  
Wen-Chin Tsen ◽  
...  

Highly aligned, tightly packed, single-, double-, and mixed-layer polycarbonate (PC) hollow fibrous membranes were prepared using two-fluid coaxial electrospinning.

2014 ◽  
Vol 1058 ◽  
pp. 78-82 ◽  
Author(s):  
Deng Guang Yu ◽  
Ying Xu ◽  
Song Liu ◽  
Yu Hai Wang ◽  
Xiao Duan ◽  
...  

A modified coaxial electrospinning process is developed for producing medicated nanofiber membranes of shellac. With pure ethanol as a sheath fluid, high quality borneol-loaded shellac nanofibers have been successfully fabricated using the modified coaxial process. Electron scanning microscopic observations demonstrated that the nanofibers had better quality than those fabricated using a single fluid electrospinning in terms of nanofiber diameters and their distributions. The former had an average diameter of 570 ± 80 nm under a sheath-to-core flow rate ratio of 0.25, whereas the later was 940 ± 230 nm. X-ray diffraction results verified that borneol existed in the shellac matrix in an amorphous state. The medicated nanofiber membranes could significantly improved the physical stability of borneol due to the favorable hydrogen bonding between the drug and the polymer matrix, as demonstrated by the weight loss experiments. The modified coaxial electrospinning process described here expands the capability of electrospinning process in generating high quality functional membranes.


RSC Advances ◽  
2014 ◽  
Vol 4 (58) ◽  
pp. 30790-30797 ◽  
Author(s):  
Yan Wang ◽  
Wande Ding ◽  
Xiuling Jiao ◽  
Dairong Chen

Flexible silica/mesoporous alumina core–shell fibrous membranes with good adsorption capacity toward Congo red have been fabricated by a coaxial electrospinning method.


2014 ◽  
Vol 693 ◽  
pp. 394-399 ◽  
Author(s):  
Lucie Vysloužilová ◽  
Jan Valtera ◽  
Karel Pejchar ◽  
Jaroslav Beran ◽  
David Lukáš

The paper is focused on the design of the electrode for needleless coaxial electrospinning. This method allows to produce core/shell nanofibers from the free surface of a polymeric two-layer. The geometry of the designed model of electrode was analyzed using the software Autodesk Simulation Multiphysics. The results of electrostatic field simulation indicate the sharp edges of the electrode as the source of high electric intensity. These sharp edges lead to the loss of the electric energy during the electrospinning process. Based on that, the new cylindrical geometry of the electrode was developed. The results of carried out experiments clearly demonstrate the enhancement of the electrospinning process stability.


2014 ◽  
Vol 215 (9) ◽  
pp. 879-887 ◽  
Author(s):  
Yun-Shao Huang ◽  
Chi-Ching Kuo ◽  
Yao-Chi Shu ◽  
Shin-Cheng Jang ◽  
Wen-Chin Tsen ◽  
...  
Keyword(s):  

2013 ◽  
Vol 395-396 ◽  
pp. 138-143 ◽  
Author(s):  
Deng Guang Yu ◽  
Min Hao Hu ◽  
Wen Zhou ◽  
Bi Yu Chen ◽  
Xia Wang

The present study investigates the preparation of sustained release drug-loaded nanofibers using a modified coaxial electrospinning process where only solvent is exploited as sheath fluid. Drug-loaded ethyl cellulose (EC) nanofibers are successfully generated smoothly and continuously without any clogging through the coaxial process, in which ethanol is used as sheath fluid and EC and ketoprofen (KET) are taken as the filament-forming matrix and active pharmaceutical ingredient, respectively. Field-emission scanning electron microscopic observations demonstrated that the nanofibers diameter can be manipulated through the sheath fluid flow rate. The composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that KET in the nanofibers has a fine sustained release profile via a typical Fickian diffusion mechanism. The modified coaxial electrospinning with solvent as sheath fluid can be a useful tool for developing novel sustained release drug delivery nanofibers.


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