Screening and verification of linearly dependent biomarkers with acute toxicity induced by Aconiti Radix based on liquid chromatography-mass spectrometry-based metabolite profiling

RSC Advances ◽  
2015 ◽  
Vol 5 (126) ◽  
pp. 103915-103924 ◽  
Author(s):  
Yubo Li ◽  
Zhiguo Hou ◽  
Yuming Wang ◽  
Lei Wang ◽  
Liang Ju ◽  
...  

We built a method that has three parts: first is to screen the biomarkers with metabolic profiling analysis; second is to determine the linear dependence with acute toxicity biomarkers; third is to validate the biomarkers with different Aconiti Radix involved medicine.

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