A metabolic profiling analysis of the nephrotoxicity of acyclovir in rats using ultra performance liquid chromatography/mass spectrometry

2016 ◽  
Vol 46 ◽  
pp. 234-240 ◽  
Author(s):  
Wenmin Xing ◽  
Lili Gu ◽  
Xinyue Zhang ◽  
Jiadong Xu ◽  
Hong Lu
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Metabolic Profiling ◽  
Ultra Performance Liquid Chromatography ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Metabolic Profiling Analysis ◽  
Profiling Analysis

Screening and verification of linearly dependent biomarkers with acute toxicity induced by Aconiti Radix based on liquid chromatography-mass spectrometry-based metabolite profiling

RSC Advances ◽  
2015 ◽  
Vol 5 (126) ◽  
pp. 103915-103924 ◽  
Author(s):  
Yubo Li ◽  
Zhiguo Hou ◽  
Yuming Wang ◽  
Lei Wang ◽  
Liang Ju ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Acute Toxicity ◽  
Linear Dependence ◽  
Metabolic Profiling ◽  
Metabolite Profiling ◽  
Liquid Chromatography Mass Spectrometry ◽  
Toxicity Biomarkers ◽  
Metabolic Profiling Analysis ◽  
Profiling Analysis

We built a method that has three parts: first is to screen the biomarkers with metabolic profiling analysis; second is to determine the linear dependence with acute toxicity biomarkers; third is to validate the biomarkers with different Aconiti Radix involved medicine.

The plasma metabolic profiling of chronic acephate exposure in rats via an ultra-performance liquid chromatography-mass spectrometry based metabonomic method

2015 ◽  
Vol 11 (2) ◽  
pp. 506-515 ◽  
Author(s):  
Yurong Hou ◽  
Can Cao ◽  
Wei Bao ◽  
Shuang Yang ◽  
Haidan Shi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Metabolic Profiling ◽  
Low Dose ◽  
Ultra Performance Liquid Chromatography ◽  
Toxic Effects ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

This study aimed to investigate the toxic effects of long-term, low-dose acephate administration on rats using ultra-performance liquid chromatography-mass spectrometry.

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