Intracellular thiol-responsive nanosized drug carriers self-assembled by poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(ethylene glycol) having multiple bioreducible disulfide linkages in hydrophobic blocks

RSC Advances ◽  
2016 ◽  
Vol 6 (19) ◽  
pp. 15558-15576 ◽  
Author(s):  
Seung Yeon Moon ◽  
Yeon Su Choi ◽  
Jung-Kyo Cho ◽  
Minjong Yu ◽  
Eunji Lee ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Polymeric Nanoparticles ◽  
Drug Carriers ◽  
Effective Drug ◽  
Poly Ethylene Glycol ◽  
Hydrophobic Domain ◽  
Disulfide Linkages ◽  
Self Assembled ◽  
Poly Ethylene

Intracellular thiol can trigger effective drug release from polymeric nanoparticles having multiple disulfide linkages in the hydrophobic domain.

Facile Fabrication of Diblock Methoxy Poly(ethylene glycol)-poly(tetramethylene carbonate) and Its Self-Assembled Micelles as Drug Carriers

2009 ◽  
Vol 1 (12) ◽  
pp. 2729-2737 ◽  
Author(s):  
Jun Feng ◽  
Wei Su ◽  
Hua-fen Wang ◽  
Fu-wei Huang ◽  
Xian-zheng Zhang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Drug Carriers ◽  
Poly Ethylene Glycol ◽  
Facile Fabrication ◽  
Self Assembled ◽  
Poly Ethylene

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)

2013 ◽  
Vol 813 ◽  
pp. 399-402
Author(s):  
Chimsook Thitipha ◽  
Thitiphan Chimsook
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Diffusion Method ◽  
Poly Ethylene Glycol ◽  
Matrix Polymer ◽  
Percentage Yield ◽  
Poly Ethylene ◽  
Composition Ratios

The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly (ethylene glycol) by solvent diffusion method. The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly (ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres. The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface. Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen. The concentration and size of poly (ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.

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