Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)
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The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly (ethylene glycol) by solvent diffusion method. The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly (ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres. The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface. Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen. The concentration and size of poly (ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.
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2006 ◽
Vol 111
(3)
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pp. 263-270
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2009 ◽
Vol 4
(1)
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pp. 104-109
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2019 ◽
Vol 113
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pp. 165-175
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2020 ◽
Vol 165
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pp. 1047-1054
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2003 ◽
Vol 14
(8)
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pp. 777-802
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