Albumin–polymer conjugate nanoparticles and their interactions with prostate cancer cells in 2D and 3D culture: comparison between PMMA and PCL

2016 ◽  
Vol 4 (11) ◽  
pp. 2017-2027 ◽  
Author(s):  
Yanyan Jiang ◽  
Hongxu Lu ◽  
Aydan Dag ◽  
Gene Hart-Smith ◽  
Martina H. Stenzel
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
3D Culture ◽  
Prostate Cancer Cells ◽  
Polymer Conjugate ◽  
Self Assembled ◽  
Amphiphilic Nanoparticles ◽  
2D And 3D

Using proteins as the hydrophilic moiety can dramatically improve the biodegradability and biocompatibility of self-assembled amphiphilic nanoparticles in the field of nanomedicine.

A self-assembled π-conjugated system as an anti-proliferative agent in prostate cancer cells and a probe for intra-cellular imaging

RSC Advances ◽  
2014 ◽  
Vol 4 (89) ◽  
pp. 48433-48437 ◽  
Author(s):  
Krishnamoorthy Lalitha ◽  
Preethi Jenifer ◽  
Y. Siva Prasad ◽  
Kumarasamy Muthusamy ◽  
George John ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Renewable Resource ◽  
Cellular Imaging ◽  
Prostate Cancer Cells ◽  
Conjugated Systems ◽  
Pc3 Cells ◽  
Self Assembled

Herein, self-assembled π-conjugated systems derived from renewable resource are reported as a probe for intra-cellular imaging and an anti-proliferative agent for PC3 cells.

Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

2019 ◽  
Vol 85 ◽  
pp. 455-468 ◽  
Author(s):  
Rone Aparecido De Grandis ◽  
Patrick Wellington da Silva dos Santos ◽  
Katia Mara de Oliveira ◽  
Ana Rita Tomazela Machado ◽  
Alexandre Ferro Aissa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
2D And 3D

scholarly journals Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ezgi Oner ◽  
Mustafa Kotmakci ◽  
Anne-Marie Baird ◽  
Steven G. Gray ◽  
Bilge Debelec Butuner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Transfection Efficiency ◽  
3D Culture ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Great Promise ◽  
Prostate Cancer Cells ◽  
Tumor Spheroids

Abstract Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carriers are needed. Results Here, we developed cationic solid lipid nanoparticles (cSLNs) to carry siRNAs targeting EphA2 receptor tyrosine kinase (siEphA2), which is overexpressed in many solid tumors including prostate cancer. Using DDAB cationic lipid instead of DOTMA reduced nanoparticle size and enhanced both cellular uptake and gene silencing in prostate cancer cells. DDAB-cSLN showed better cellular uptake efficiency with similar silencing compared to commercial transfection reagent (Dharmafect 2). After verifying the efficacy of siEphA2-loaded nanoparticles, we further evaluated a potential combination with a histone lysine demethylase inhibitor, JIB-04. Silencing EphA2 by siEphA2-loaded DDAB-cSLN did not affect the viability (2D or 3D culture), migration, nor clonogenicity of PC-3 cells alone. However, upon co-administration with JIB-04, there was a decrease in cellular responses. Furthermore, JIB-04 decreased EphA2 expression, and thus, silencing by siEphA2-loaded nanoparticles was further increased with co-treatment. Conclusions We have successfully developed a novel siRNA-loaded lipid nanoparticle for targeting EphA2. Moreover, preliminary results of the effects of JIB-04, alone and in combination with siEphA2, on prostate cancer cells and prostate cancer tumor spheroids were presented for the first time. Our delivery system provides high transfection efficiency and shows great promise for targeting other genes and cancer types in further in vitro and in vivo studies.

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growth

Phytomedicine ◽  
2021 ◽  
pp. 153826
Author(s):  
Nuha Mahmoud ◽  
Mona Dawood ◽  
Qi Huang ◽  
Jerome P.L. Ng ◽  
Fang Ren ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
2D And 3D

scholarly journals The Biological Behavior of Prostate Cancer Cells in 3D Culture Systems

2008 ◽  
Vol 128 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Masatoshi WATANABE ◽  
Akimitsu TAKAGI
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
3D Culture ◽  
Biological Behavior ◽  
Prostate Cancer Cells ◽  
Culture Systems

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells
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