scholarly journals Infrared spectral histopathology using haematoxylin and eosin (H&E) stained glass slides: a major step forward towards clinical translation

The Analyst ◽  
2017 ◽  
Vol 142 (8) ◽  
pp. 1258-1268 ◽  
Author(s):  
Michael J. Pilling ◽  
Alex Henderson ◽  
Jonathan H. Shanks ◽  
Michael D. Brown ◽  
Noel W. Clarke ◽  
...  
Keyword(s):  
Diagnostic Tool ◽  
Clinical Translation ◽  
Great Promise ◽  
Stained Glass ◽  
Major Step ◽  
Glass Slides ◽  
Important Diagnostic Tool ◽  
Infrared Spectral ◽  
Spectral Histopathology

Infrared spectral histopathology has shown great promise as an important diagnostic tool, with the potential to complement current pathological methods.

scholarly journals Infrared spectral histopathology (SHP): a novel diagnostic tool for the accurate classification of lung cancer

2012 ◽  
Vol 92 (9) ◽  
pp. 1358-1373 ◽  
Author(s):  
Benjamin Bird ◽  
Milos̆ Miljković ◽  
Stan Remiszewski ◽  
Ali Akalin ◽  
Mark Kon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Diagnostic Tool ◽  
Infrared Spectral ◽  
Spectral Histopathology

Wood and Bark Anatomy of Lauraceae. ii. Licaria Aublet

IAWA Journal ◽  
1985 ◽  
Vol 6 (3) ◽  
pp. 187-199 ◽  
Author(s):  
Hans Georg Richter
Keyword(s):  
Diagnostic Tool ◽  
Secondary Xylem ◽  
Secondary Phloem ◽  
Structural Profile ◽  
Quantitative Characters ◽  
Important Diagnostic Tool ◽  
Species Groups ◽  
Bark Anatomy

Qualitative features of the secondary xylem of Licaria present a rather uniform structural profile. Constant differences in primarily quantitative characters lead to the formation of speeies groups wh ich loosely correspond to infrageneric sections based on floral and vegetative morphology. This subdivision is strongly corroborated by the highly variable secondary phloem structurc revealing considerable diversity in type and distribution of sc1erenchymatic tissues. Inorganic inclusions in the secondary xylem, crystals and silica, constitute an important diagnostic tool for differentiating certain species and species groups, but are hardly of importance in the bark.

scholarly journals T-Scan III System Diagnostic Tool for Digital Occlusal Analysis in Orthodontics – a Modern Approach

PRILOZI ◽  
2014 ◽  
Vol 35 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Vesna Trpevska ◽  
Gordana Kovacevska ◽  
Alberto Benedeti ◽  
Bozidar Jordanov
Keyword(s):  
Systematic Review ◽  
Diagnostic Tool ◽  
Reference Lists ◽  
Great Promise ◽  
Inclusion Criteria ◽  
Modern Approach ◽  
Diagnostic Screening ◽  
Randomized Controlled ◽  
Language Restriction ◽  
Screening Device

Abstract Introduction: This systematic literature review was performed to establish the mechanism, methodology, characteristics, clinical application and opportunities of the T-Scan III System as a diagnostic tool for digital occlusal analysis in different fields of dentistry, precisely in orthodontics. Methods: Searching of electronic databases, using MEDLINE and PubMed, hand searching of relevant key journals, and screening of reference lists of included studies with no language restriction was performed. Publications providing statistically examined data were included for systematic review. Results: Twenty potentially relevant Randomized Controlled Trials (RCTs) were identified. Only ten met the inclusion criteria. The literature demonstrates that using digital occlusal analysis with T-Scan III System in orthodontics has significant advantage with regard to the capability of measuring occlusal parameters in static positions and during dynamic of the mandible. Conclusion: Within the scope of this systematic review, there is evidence to support that T-Scan system is rapid and accurate in identifying the distribution of the tooth contacts and it shows great promise as a clinical diagnostic screening device for occlusion and for improving the occlusion after various dental treatments. Additional clinical studies are required to advance the indication filed of this system. Importance of using digital occlusal T-Scan analysis in orthodontics deserves further investigation.

scholarly journals Production of γ-Interferon by Peripheral Blood Mononuclear Cells: An Important Diagnostic Tool for Detection of Subclinical Paratuberculosis

1996 ◽  
Vol 8 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Judith R. Stabel
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Diagnostic Tool ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Pokeweed Mitogen ◽  
Complete Medium ◽  
Similar Response ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Important Diagnostic Tool

Peripheral blood mononuclear cells were isolated from noninfected control cows and from cows with either subclinical or clinical paratuberculosis (Johne s disease). Cells were incubated for 6, 12, 24, and 48 hours in complete medium with the following mitogens: concanavalin A (ConA), phytohemagglutinin-P (PHAP), pokeweed mitogen (PWM), and Escherichia coli lipopolysaccharide. In addition, cells were incubated for the same time periods with a Mycobacterium paratuberculosis sonicate (MpS) and live and heat-killed M. paratuberculosis at 10:1 bacteria: cell ratio. After incubation, cell-free supernatants were analyzed for y-interferon (γ-IFN) production. Cells from subclinical cows produced significantly higher levels of γ-IFN than did cells from clinical animals after stimulation with mitogens ConA, PHAP, and PWM. Levels of γ-IFN produced by noninfected control animals generally followed the pattern of those of subclinical animals. After incubation with MpS, significantly greater quantities of γ-IFN were produced by cells isolated from subclinical animals than by cells from clinical cows and noninfected controls. Stimulation of cells with heat-killed or live M. paratuberculosis evoked a similar response. This study indicates that γ-IFN production by peripheral blood mononuclear cells in response to M. paratuberculosis antigen may be an important diagnostic tool for the detection of paratuberculosis in subclinically affected animals.

Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsy

2005 ◽  
Vol 73 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Justin S. Smith ◽  
Alfredo Quiñones-Hinojosa ◽  
Nicholas M. Barbaro ◽  
Michael W. McDermott
Keyword(s):  
Diagnostic Tool ◽  
Stereotactic Biopsy ◽  
Important Diagnostic Tool

scholarly journals EPEN-14. GENERATION OF A C11orf95-RELA FUSION TARGETING ANTIBODY AS A DIAGNOSTIC TOOL FOR SUPRATENTORIAL EPENDYMOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii310-iii310
Author(s):  
Lisa Ruff ◽  
Denice Y Chan ◽  
Lesley Jenkinson ◽  
Stuart Haynes ◽  
Mark Austin ◽  
...  
Keyword(s):  
Diagnostic Tool ◽  
Fusion Gene ◽  
Affinity Maturation ◽  
Mouse Tissue ◽  
Great Promise ◽  
Nuclear Staining ◽  
Screening Process ◽  
Similar Treatment ◽  
Genomic Studies ◽  
Supratentorial Ependymoma

Abstract Ependymomas account for 10% of paediatric brain tumours and arise in the ventricular walls of the central nervous system. Ependymomas were previously classified as one tumour type and all patients received similar treatment. However, recent genomic studies have identified nine different molecular subgroups of the disease, including one supratentorial subtype characterized by a novel fusion gene C11ORF95-RELA. When introduced into neural stem cells, this fusion is a potent driver of tumorigenesis and its presence in patient samples has previously also been shown to negatively correlate with overall survival. Accurate diagnosis of this subgroup is currently limited to sophisticated approaches such as break-apart FISH or RNA sequencing. Here, we report the generation of a C11ORF95-RELA Fusion-specific antibody that can be used for routine immunohistochemistry (IHC). Candidate antibodies were first selected using phage display and favourable leads were subjected to affinity maturation using ribosome display after a screening process involving immunoblotting and IHC. Further IHC-based screening of affinity-matured candidates using fusion-positive and -negative mouse tissue as well as human fusion-negative ependymoma tumour tissue produced one lead antibody. The antibody detects fusion-specific nuclear staining pattern on fusion-positive tissue and does not react with fusion-negative tissues. This candidate antibody is currently being tested on human fusion-positive ependymoma tissue. This accurate diagnostic tool holds great promise to transform the management of patients with supratentorial ependymoma.

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