“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

2016 ◽  
Vol 52 (74) ◽  
pp. 11151-11154 ◽  
Author(s):  
Liyang Shi ◽  
Yuanyuan Han ◽  
Jöns Hilborn ◽  
Dmitri Ossipov
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Acidic Environment ◽  
Self Healing ◽  
Nanoparticle Delivery ◽  
Neutral Ph ◽  
Smart Drug

A new self-healing hydrogel is developed using dynamic coordinate bonds between drug loaded MgSiO3 nanoparticles and bisphosphonate functionalized hyaluronic acid. The nanocomposite network is stable at neutral pH, but is disassembled in an acidic environment, providing “smart” drug release.

3D printable self-healing hyaluronic acid/chitosan polycomplex hydrogels with drug release capability

2021 ◽  
Author(s):  
Sheila Maiz-Fernández ◽  
Nagore Barroso ◽  
Leyre Pérez-Álvarez ◽  
Unai Silván ◽  
José Luis Vilas-Vilela ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Self Healing

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

Smart Drug Release Systems Based on Stimuli-Responsive Polymers

2013 ◽  
Vol 13 (9) ◽  
pp. 1369-1380 ◽  
Author(s):  
Guangyan Qing ◽  
Minmin Li ◽  
Lijing Deng ◽  
Ziyu Lv ◽  
Peng Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Smart Drug

Transforming sustained release into on-demand release: self-healing guanosine–borate supramolecular hydrogels with multiple responsiveness for Acyclovir delivery

2020 ◽  
Vol 8 (22) ◽  
pp. 6190-6203
Author(s):  
Cheng-guang Wu ◽  
Xiang Wang ◽  
Yun-feng Shi ◽  
Bin-cheng Wang ◽  
Wei Xue ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
Self Healing ◽  
On Demand

Supramolecular hydrogels derived from natural nucleoside have promising applications for on-demand drug release with controlled on/off switch and adjustable release kinetics in response to various stimuli.

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