Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-β peptides

2017 ◽  
Vol 19 (24) ◽  
pp. 16257-16266 ◽  
Author(s):  
Misaki Kinoshita ◽  
Erina Kakimoto ◽  
Mayu S. Terakawa ◽  
Yuxi Lin ◽  
Tatsuya Ikenoue ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Model Membrane ◽  
Amyloid Formation ◽  
Unilamellar Vesicles ◽  
Aβ Peptides ◽  
Size Dependent ◽  
Large Unilamellar Vesicles

We herein report the mechanism of amyloid formation of amyloid-β (Aβ) peptides on small (SUV) and large unilamellar vesicles (LUVs), which consist of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipids.

scholarly journals BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes

Biosensors ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 192
Author(s):  
Sergei V. Dzyuba
Keyword(s):  
Small Molecule ◽  
Conformational Changes ◽  
Self Assembly ◽  
Structural Changes ◽  
Photophysical Properties ◽  
Amyloid Β ◽  
Amyloid Formation ◽  
Diverse Range ◽  
Aβ Peptides ◽  
Underlying Mechanisms

Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are among the most versatile small molecule fluorophores. BODIPY scaffolds could be functionalized to tune their photophysical properties to the desired ranges as well as to adapt these dyes to various types of conditions and environments. Thus, BODIPY dyes could be viewed as unique platforms for the design of probes and sensors that are capable of detecting and tracking structural changes of various Aβ aggregates. This review summarizes currently available examples of BODIPY dyes that have been used to investigate conformational changes of Aβ peptides, self-assembly processes of Aβ, as well as Aβ interactions with various molecules.

A theoretical study on the molecular determinants of the affibody protein ZAβ3bound to an amyloid β peptide

2015 ◽  
Vol 17 (26) ◽  
pp. 16886-16893 ◽  
Author(s):  
Xu Wang ◽  
Xianqiang Sun ◽  
Guanglin Kuang ◽  
Hans Ågren ◽  
Yaoquan Tu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Theoretical Study ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Aβ Peptides ◽  
Molecular Determinants

The investigation of the (ZAβ3)2:Aβ complex highlights the energetic contribution of affibody residues to the binding with alzheimer's disease associated Aβ peptides.

Amyloid β-peptide interaction with GM1 containing model membrane

2020 ◽  
pp. 1-24
Author(s):  
Rita Carrotta ◽  
Fabio Librizzi ◽  
Maria Rosalia Mangione ◽  
Silvia Vilasi ◽  
Oscar Moran
Keyword(s):  
Amyloid Β ◽  
Model Membrane ◽  
Amyloid Β Peptide ◽  
Peptide Interaction

scholarly journals α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

Biochemistry ◽  
2009 ◽  
Vol 48 (11) ◽  
pp. 2304-2306 ◽  
Author(s):  
Adam J. Trexler ◽  
Elizabeth Rhoades
Keyword(s):  
Unilamellar Vesicles ◽  
Large Unilamellar Vesicles

scholarly journals Gallium nanoparticles as novel inhibitors of Aβ40 aggregation

2021 ◽  
Author(s):  
Rolando Oyola ◽  
Deguo Du ◽  
Idalia Ramos ◽  
Kyabeth Torres ◽  
Ambar S Delgado ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Plaques ◽  
Aβ Peptides ◽  
Gallium Nanoparticles

Alzheimer’s disease (AD) has been consistently related to the formation of senile amyloid plaques mainly composed of amyloid β (Aβ) peptides. The toxicity of Aβ aggregates has been indicated to...

Evolution of the thermotropic properties of large unilamellar vesicles (LUV)

1984 ◽  
Vol 40 (7) ◽  
pp. 715-717 ◽  
Author(s):  
M. Vandenbranden ◽  
C. Stil ◽  
R. Brasseur ◽  
J. -M. Ruysschaert
Keyword(s):  
Unilamellar Vesicles ◽  
Large Unilamellar Vesicles ◽  
Thermotropic Properties

The Efficacies of Cell-Penetrating Peptides in Accumulating in Large Unilamellar Vesicles Depend on their Ability To Form Inverted Micelles

ChemBioChem ◽  
2014 ◽  
Vol 15 (6) ◽  
pp. 884-891 ◽  
Author(s):  
Jean-Marie Swiecicki ◽  
Annika Bartsch ◽  
Julien Tailhades ◽  
Margherita Di Pisa ◽  
Benjamin Heller ◽  
...  
Keyword(s):  
Cell Penetrating Peptides ◽  
Unilamellar Vesicles ◽  
Large Unilamellar Vesicles ◽  
Cell Penetrating
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