scholarly journals Bridging the gap: microfluidic devices for short and long distance cell–cell communication

Lab on a Chip ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 1009-1023 ◽  
Author(s):  
Timothy Quang Vu ◽  
Ricardo Miguel Bessa de Castro ◽  
Lidong Qin
Keyword(s):  
Cancer Research ◽  
Cell Communication ◽  
Microfluidic Devices ◽  
Long Distance ◽  
Cell Cell

This review will cover how cell–cell microfluidic devices have made advancements in fields like immunology, neuroscience, ophthalmology, cancer research, and more.

scholarly journals Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?

2013 ◽  
Vol 24 (8) ◽  
pp. 1095-1098 ◽  
Author(s):  
Nathan M. Sherer
Keyword(s):  
Calcium Signaling ◽  
Electrical Coupling ◽  
Cell Communication ◽  
Tunneling Nanotubes ◽  
Long Distance ◽  
Membrane Nanotubes ◽  
Pathogenic Agents ◽  
Key Questions ◽  
Cell Cell

Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator.

scholarly journals Tracing back the origin of cell-cell communication: Hydra vulgaris releases extracellular vesicles delivering regulators of head and foot regeneration

2021 ◽  
Author(s):  
Maria Moros ◽  
Eugenio Fergola ◽  
Valentina Marchesano ◽  
Margherita Mutarelli ◽  
Giuseppina Tommasini ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Cell Communication ◽  
Population Level ◽  
Active Role ◽  
Target Cells ◽  
Chemical Information ◽  
Long Distance ◽  
Hydra Vulgaris ◽  
And Function ◽  
Cell Cell

Abstract Recent body of evidence demonstrates that extracellular vesicles (EVs) represent the first language of cell-cell communication emerged during evolution. In aquatic environments, transferring signals between cells by EVs offer protection against degradation, allowing delivering of chemical information in high local concentrations to the target cells. The packaging of multiple signals, including those of hydrophobic nature, ensures target cells to receive the same EV-conveyed messages, and the coordination of a variety of physiological processes across cells of a single organisms, or at the population level, i.e. mediating the population´s response to changing environmental conditions. Here, we purified EVs from the medium of the freshwater invertebrate Hydra vulgaris, and the molecular profiling by proteomic and transcriptomic analyses revealed multiple markers of the exosome EV subtype. Moreover, positive and negative regulators of the Wnt/β-catenin signaling pathway, the major developmental pathway acting in body axial patterning, were identified. Functional analysis on amputated polyps revealed EV ability to interfere with both head and foot regeneration, suggesting an active role in setting up tissue gradients and oro-aboral polarity through delivery of short and long-distance signals. Our results open the path to unravel EV biogenesis and function in all cnidarian species, tracing back the origin of the cell-cell, cross-species or cross-kingdom communication in aquatic ecosystems

scholarly journals Probing cell–cell communication with microfluidic devices

Lab on a Chip ◽  
2013 ◽  
Vol 13 (16) ◽  
pp. 3152 ◽  
Author(s):  
Feng Guo ◽  
Jarrod B. French ◽  
Peng Li ◽  
Hong Zhao ◽  
Chung Yu Chan ◽  
...  
Keyword(s):  
Cell Communication ◽  
Microfluidic Devices ◽  
Cell Cell

scholarly journals Anaesthetics and plants: from sensory systems to cognition-based adaptive behaviour

PROTOPLASMA ◽  
2021 ◽  
Vol 258 (2) ◽  
pp. 449-454 ◽  
Author(s):  
František Baluška ◽  
Ken Yokawa
Keyword(s):  
Action Potentials ◽  
Cell Communication ◽  
Sensory Systems ◽  
Neural Systems ◽  
Adaptive Behaviour ◽  
Long Distance ◽  
Specific Behaviour ◽  
Endogenous Substances ◽  
Cell Cell

AbstractPlants are not only sensitive to exogenous anaesthetics, but they also produce multitudes of endogenous substances, especially when stressed, that often have anaesthetic and anelgesic properties when applied to both humans and animals. Moreover, plants rely on neurotransmitters and their receptors for cell-cell communication and integration in a similar fashion to the use of neural systems in animals and humans. Plants also use their plant-specific sensory systems and neurotransmitter-based communication, including long-distance action potentials, to manage stress via cognition-like plant-specific behaviour and adaptation.

Sign in / Sign up

Export Citation Format

Share Document