Design, synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα)
2016 ◽
Vol 14
(20)
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pp. 4576-4581
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Keyword(s):
A new fluorescent-labeled inhibitor for PKACα was developed that potently inhibits the kinase (IC50 = 11.8 nM), is >100-fold selective for PKACα, and irreversibly labels Cys199.
The in vitro phosphorylation of chromatin by the catalytic subunit of cAMP-dependent protein kinase.
1982 ◽
Vol 257
(11)
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pp. 6056-6063
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1987 ◽
Vol 252
(1)
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pp. F19-F25
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1985 ◽
Vol 4
(11)
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pp. 2801-2806
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1994 ◽
Vol 269
(3)
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pp. 2316-2323
1992 ◽
Vol 267
(24)
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pp. 16824-16828
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1990 ◽
Vol 265
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pp. 6896-6907
1983 ◽
Vol 258
(6)
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pp. 3682-3692
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2002 ◽
Vol 277
(52)
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pp. 50885-50892
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