Efficient free radical generation against cancer cells by low-dose X-ray irradiation with a functional SPC delivery nanosystem

2016 ◽  
Vol 4 (35) ◽  
pp. 5863-5872 ◽  
Author(s):  
Yiran Shao ◽  
Liyao Wang ◽  
Jingke Fu ◽  
Chao Shi ◽  
Jiaqiang Xu ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cells ◽  
Low Dose ◽  
Low Energy ◽  
X Ray ◽  
Free Radical Generation ◽  
Radical Generation

SPC@HMSNs–PAA can provide oxygen, which induce overproduction of radicals to kill cancer cells even under low energy X-ray irradiation.

scholarly journals Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaomin Li ◽  
Yang Liu ◽  
Fei Fu ◽  
Mingbo Cheng ◽  
Yutong Liu ◽  
...  
Keyword(s):  
Free Radical ◽  
Laser Irradiation ◽  
Attenuation Coefficient ◽  
Tumor Therapy ◽  
Ct Imaging ◽  
Tumor Growth Inhibition ◽  
Step Method ◽  
X Ray ◽  
Free Radical Generation ◽  
Radical Generation

Abstract Inconvenient dual-laser irradiation and tumor hypoxic environment as well as limited judgment of treating region have impeded the development of combined photothermal and photodynamic therapies (PTT and PDT). Herein, Bi2Se3@AIPH nanoparticles (NPs) are facilely developed to overcome these problems. Through a one-step method, free radical generator (AIPH) and phase transition material (lauric acid, LA, 44–46 °C) are encapsulated in hollow bismuth selenide nanoparticles (Bi2Se3 NPs). Under a single 808-nm laser irradiation at the tumor area, hyperthermia produced by Bi2Se3 not only directly leads to cell death, but also promotes AIPH release by melting LA and triggers free radical generation, which could further eradicate tumor cells in hypoxic environments. Moreover, Bi2Se3 with high X-ray attenuation coefficient endows the NPs with high computed tomography (CT) imaging capability, which is important for treating area determination. The results exhibit that Bi2Se3@AIPH NPs possesses 31.2% photothermal conversion efficiency for enhanced PTT, ideal free radical generation for oxygen-independent PDT, and 37.77 HU mL mg−1 X-ray attenuation coefficient for CT imaging with high quality. Most importantly, the tumor growth inhibition rate by synergistic PTT, PDT, and following immunotherapy is 99.6%, and even one tumor disappears completely, which demonstrates excellent cascaded synergistic effect of Bi2Se3@AIPH NPs for the tumor therapy.

Photochemical strategies for the green synthesis of ultrathin Au nanosheets using photoinduced free radical generation and their catalytic properties

Nanoscale ◽  
2018 ◽  
Vol 10 (39) ◽  
pp. 18805-18811 ◽  
Author(s):  
Suisui He ◽  
Jun Hai ◽  
Tianrong Li ◽  
Sha Liu ◽  
Fengjuan Chen ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Free Radical ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Catalytic Properties ◽  
Free Radical Generation ◽  
Unsaturated Aldehydes ◽  
Highly Sensitive ◽  
Radical Generation

A photochemical strategy using photoinduced methylene blue radicals for the green synthesis of ultrathin Au nanosheets. The resulting Au nanosheets show highly sensitive recognition of cancer cells and efficient activity and selectivity toward the hydrogenation of α,β-unsaturated aldehydes.

Lysosomes activating chain reactions against cancer cells with a pH-switched prodrug/procatalyst co-delivery nanosystem

2017 ◽  
Vol 5 (5) ◽  
pp. 996-1004 ◽  
Author(s):  
Jingke Fu ◽  
Yingchun Zhu
Keyword(s):  
Free Radical ◽  
Cancer Cells ◽  
Free Radical Generation ◽  
Chain Reactions ◽  
Radical Generation

A selective intracellular free radical generation strategy against cancer cells is developed by lysosomal bioactivation of a prodrug/procatalyst co-delivery nanosystem.

Myocardial haem proteins, oxidant stress & free radical generation

1990 ◽  
Vol 9 ◽  
pp. 182
Author(s):  
Catherine Rice-Evans ◽  
Jeremy J.O. Turner ◽  
Emma Newman ◽  
Michael J. Davies
Keyword(s):  
Free Radical ◽  
Oxidant Stress ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Haem Proteins
Sign in / Sign up

Export Citation Format

Share Document