In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

2018 ◽  
Vol 54 (24) ◽  
pp. 2962-2965 ◽  
Author(s):  
Zhimei He ◽  
Yan Xiao ◽  
Jian-Rong Zhang ◽  
Penghui Zhang ◽  
Jun-Jie Zhu
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Cancer Cell ◽  
Tumor Hypoxia ◽  
Large Pore ◽  
In Situ Formation

Endogenous H+-/H2O2-triggered nanohybrids for cancer cell-specific and O2 self-sufficient PDT: a promising platform for effective PDT against tumor hypoxia.

Cancer‐Cell‐Activated In‐Situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

2021 ◽  
Author(s):  
Yuanbo Wang ◽  
Shidang Xu ◽  
Leilei Shi ◽  
Cathleen Teh ◽  
Guobin Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
In Situ Synthesis ◽  
Mitochondria Targeting

Cancer‐Cell‐Activated In‐Situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

2021 ◽  
Author(s):  
Yuanbo Wang ◽  
Shidang Xu ◽  
Leilei Shi ◽  
Cathleen Teh ◽  
Guobin Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
In Situ Synthesis ◽  
Mitochondria Targeting

Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy

Biomaterials ◽  
2018 ◽  
Vol 181 ◽  
pp. 310-317 ◽  
Author(s):  
Hairong Wang ◽  
Yu Chao ◽  
Jingjing Liu ◽  
Wenwen Zhu ◽  
Guanglin Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Situ Polymerization ◽  
Tumor Hypoxia

scholarly journals Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer

2021 ◽  
Vol 22 (19) ◽  
pp. 10506
Author(s):  
Dimakatso R. Mokoena ◽  
Blassan P. George ◽  
Heidi Abrahamse
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Cell ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Normal Cells ◽  
Cell Death Mechanisms

Breast cancer is the second most common cancer globally and the pioneering cause of mortality among women. It usually begins from the ducts or lobules, referred to as ductal carcinoma in situ, or lobular carcinoma in situ. Age, mutations in Breast Cancer Gene 1 or 2 (BRCA1 or BRCA2) genes, and dense breast tissue are the highest risk factors. Current treatments are associated with various side effects, relapse, and a low quality of life. Although conventional treatments, such as surgery and chemotherapy, have been used for decades, their adverse side effects on normal cells and tissues pose a major weakness, which calls for a non-invasive treatment option. Photodynamic therapy (PDT) has proven to be a promising form of cancer therapy. It is less invasive, target-specific, and with reduced cytotoxicity to normal cells and tissues. It involves the use of a photosensitizer (PS) and light at a specific wavelength to produce reactive oxygen species. One of the reasons for the target specificity is associated with the dense vascularization of cancer tissues, which tends to increase the surface area for the PS uptake. Photosensitizers are light-sensitive molecules, which result in cancer cell destruction followed by light irradiation. Depending on the localization of the PS within the cancer cell, its destruction may be via apoptosis, necrosis, or autophagy. This review focuses on the breast cancer etiopathology and PDT-induced cell death mechanisms in breast cancer cells.

Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (48) ◽  
pp. 22937-22945 ◽  
Author(s):  
Xiaoli Cai ◽  
Yanan Luo ◽  
Yang Song ◽  
Dong Liu ◽  
Hongye Yan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Three Dimensional ◽  
Silica Nanospheres ◽  
Highly Efficient ◽  
In Situ Formation ◽  
Mitochondria Targeting ◽  
Mesoporous Silica Nanospheres

A mitochondria-targeting and O2-evolving PDT nanoplatform based on 3D-dendritic MSNs was proposed for highly efficient cancer PDT treatment.

Integrating in situ formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy

2019 ◽  
Vol 55 (98) ◽  
pp. 14785-14788 ◽  
Author(s):  
Xiaochun Hu ◽  
Yonglin Lu ◽  
Xiaoke Shi ◽  
Tianming Yao ◽  
Chunyan Dong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Situ Formation

A multi-functional nanoplatform (M-Pt-BCD) for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy is described.

Cancer cell-targeted nanoprobe for multilayer imaging of diverse biomarkers and precise photodynamic therapy

2020 ◽  
Vol 56 (96) ◽  
pp. 15208-15211
Author(s):  
Zhuolin Fu ◽  
Yingdi Wu ◽  
Chunnian Ren ◽  
Weiling Song ◽  
Xiaoru Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Cancer Biomarkers ◽  
Muc1 Mucin ◽  
Multifunctional Nanoprobe

A novel multifunctional nanoprobe was designed for cancer cell targeted multilayer imaging of two cancer biomarkers. And in situ imaging of membrane MUC1 mucin and cytoplasmic microRNA miR-21 coupled with precise photodynamic therapy was achieved.

scholarly journals Formation of compact systems of super-Earths via dynamical instabilities and giant impacts

2019 ◽  
Vol 491 (4) ◽  
pp. 5595-5620 ◽  
Author(s):  
Sanson T S Poon ◽  
Richard P Nelson ◽  
Seth A Jacobson ◽  
Alessandro Morbidelli
Keyword(s):  
Initial Conditions ◽  
Post Processing ◽  
Significant Modification ◽  
Kepler Mission ◽  
Giant Impacts ◽  
Low Mass ◽  
In Situ Formation ◽  
Dynamical Instabilities ◽  
Gaseous Envelopes

ABSTRACT The NASA’s Kepler mission discovered ∼700 planets in multiplanet systems containing three or more transiting bodies, many of which are super-Earths and mini-Neptunes in compact configurations. Using N-body simulations, we examine the in situ, final stage assembly of multiplanet systems via the collisional accretion of protoplanets. Our initial conditions are constructed using a subset of the Kepler five-planet systems as templates. Two different prescriptions for treating planetary collisions are adopted. The simulations address numerous questions: Do the results depend on the accretion prescription?; do the resulting systems resemble the Kepler systems, and do they reproduce the observed distribution of planetary multiplicities when synthetically observed?; do collisions lead to significant modification of protoplanet compositions, or to stripping of gaseous envelopes?; do the eccentricity distributions agree with those inferred for the Kepler planets? We find that the accretion prescription is unimportant in determining the outcomes. The final planetary systems look broadly similar to the Kepler templates adopted, but the observed distributions of planetary multiplicities or eccentricities are not reproduced, because scattering does not excite the systems sufficiently. In addition, we find that ∼1 per cent of our final systems contain a co-orbital planet pair in horseshoe or tadpole orbits. Post-processing the collision outcomes suggests that they would not significantly change the ice fractions of initially ice-rich protoplanets, but significant stripping of gaseous envelopes appears likely. Hence, it may be difficult to reconcile the observation that many low-mass Kepler planets have H/He envelopes with an in situ formation scenario that involves giant impacts after dispersal of the gas disc.

scholarly journals A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

2019 ◽  
Vol 31 (27) ◽  
pp. 1901893 ◽  
Author(s):  
Dongdong Wang ◽  
Huihui Wu ◽  
Wei Qi Lim ◽  
Soo Zeng Fiona Phua ◽  
Pengping Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Tumor Hypoxia ◽  
Oxygen Generation ◽  
Metal Organic
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