Cancer cell-targeted nanoprobe for multilayer imaging of diverse biomarkers and precise photodynamic therapy

2020 ◽  
Vol 56 (96) ◽  
pp. 15208-15211
Author(s):  
Zhuolin Fu ◽  
Yingdi Wu ◽  
Chunnian Ren ◽  
Weiling Song ◽  
Xiaoru Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Cancer Biomarkers ◽  
Muc1 Mucin ◽  
Multifunctional Nanoprobe

A novel multifunctional nanoprobe was designed for cancer cell targeted multilayer imaging of two cancer biomarkers. And in situ imaging of membrane MUC1 mucin and cytoplasmic microRNA miR-21 coupled with precise photodynamic therapy was achieved.

Cancer‐Cell‐Activated In‐Situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

2021 ◽  
Author(s):  
Yuanbo Wang ◽  
Shidang Xu ◽  
Leilei Shi ◽  
Cathleen Teh ◽  
Guobin Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
In Situ Synthesis ◽  
Mitochondria Targeting

Cancer‐Cell‐Activated In‐Situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

2021 ◽  
Author(s):  
Yuanbo Wang ◽  
Shidang Xu ◽  
Leilei Shi ◽  
Cathleen Teh ◽  
Guobin Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
In Situ Synthesis ◽  
Mitochondria Targeting

In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

2018 ◽  
Vol 54 (24) ◽  
pp. 2962-2965 ◽  
Author(s):  
Zhimei He ◽  
Yan Xiao ◽  
Jian-Rong Zhang ◽  
Penghui Zhang ◽  
Jun-Jie Zhu
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Cancer Cell ◽  
Tumor Hypoxia ◽  
Large Pore ◽  
In Situ Formation

Endogenous H+-/H2O2-triggered nanohybrids for cancer cell-specific and O2 self-sufficient PDT: a promising platform for effective PDT against tumor hypoxia.

scholarly journals Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer

2021 ◽  
Vol 22 (19) ◽  
pp. 10506
Author(s):  
Dimakatso R. Mokoena ◽  
Blassan P. George ◽  
Heidi Abrahamse
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Cell ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Normal Cells ◽  
Cell Death Mechanisms

Breast cancer is the second most common cancer globally and the pioneering cause of mortality among women. It usually begins from the ducts or lobules, referred to as ductal carcinoma in situ, or lobular carcinoma in situ. Age, mutations in Breast Cancer Gene 1 or 2 (BRCA1 or BRCA2) genes, and dense breast tissue are the highest risk factors. Current treatments are associated with various side effects, relapse, and a low quality of life. Although conventional treatments, such as surgery and chemotherapy, have been used for decades, their adverse side effects on normal cells and tissues pose a major weakness, which calls for a non-invasive treatment option. Photodynamic therapy (PDT) has proven to be a promising form of cancer therapy. It is less invasive, target-specific, and with reduced cytotoxicity to normal cells and tissues. It involves the use of a photosensitizer (PS) and light at a specific wavelength to produce reactive oxygen species. One of the reasons for the target specificity is associated with the dense vascularization of cancer tissues, which tends to increase the surface area for the PS uptake. Photosensitizers are light-sensitive molecules, which result in cancer cell destruction followed by light irradiation. Depending on the localization of the PS within the cancer cell, its destruction may be via apoptosis, necrosis, or autophagy. This review focuses on the breast cancer etiopathology and PDT-induced cell death mechanisms in breast cancer cells.

Tumor-Targeting Multifunctional Nanoprobe for Enhanced Photothermal/Photodynamic Therapy of Liver Cancer

Langmuir ◽  
2021 ◽  
Author(s):  
Bei Li ◽  
Xiaoya Niu ◽  
Maodi Xie ◽  
Fan Luo ◽  
Xiuyi Huang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Liver Cancer ◽  
Tumor Targeting ◽  
Multifunctional Nanoprobe

scholarly journals Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2992
Author(s):  
Xinning Wang ◽  
Dong Luo ◽  
James P. Basilion
Keyword(s):  
Photodynamic Therapy ◽  
Targeted Delivery ◽  
Cancer Biomarkers ◽  
Malignant Cell ◽  
Minimal Invasiveness ◽  
Normal Tissues ◽  
Effective Treatment Modality ◽  
Tissue Selectivity ◽  
Reduced Toxicity ◽  
Local Illumination

Photodynamic therapy (PDT) is a well-documented therapy that has emerged as an effective treatment modality of cancers. PDT utilizes harmless light to activate non- or minimally toxic photosensitizers to generate cytotoxic species for malignant cell eradication. Compared with conventional chemotherapy and radiotherapy, PDT is appealing by virtue of the minimal invasiveness, its safety, as well as its selectivity, and the fact that it can induce an immune response. Although local illumination of the cancer lesions renders intrinsic selectivity of PDT, most photosensitizers used in PDT do not display significant tumor tissue selectivity. There is a need for targeted delivery of photosensitizers. The molecular identification of cancer antigens has opened new possibilities for the development of effective targeted therapy for cancer patients. This review provides a brief overview of recent achievements of targeted delivery of photosensitizers to cancer cells by targeting well-established cancer biomarkers. Overall, targeted PDT offers enhanced intracellular accumulation of the photosensitizer, leading to improved PDT efficacy and reduced toxicity to normal tissues.

scholarly journals Biomimetic oxygen delivery nanoparticles for enhancing photodynamic therapy in triple-negative breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hanyi Fang ◽  
Yongkang Gai ◽  
Sheng Wang ◽  
Qingyao Liu ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Oxygen Delivery ◽  
Therapeutic Efficacy ◽  
Triple Negative ◽  
Oxygen Solubility ◽  
Post Injection

Abstract Background Triple-negative breast cancer (TNBC) is a kind of aggressive breast cancer with a high rate of metastasis, poor overall survival time, and a low response to targeted therapies. To improve the therapeutic efficacy and overcome the drug resistance of TNBC treatments, here we developed the cancer cell membrane-coated oxygen delivery nanoprobe, CCm–HSA–ICG–PFTBA, which can improve the hypoxia at tumor sites and enhance the therapeutic efficacy of the photodynamic therapy (PDT), resulting in relieving the tumor growth in TNBC xenografts. Results The size of the CCm–HSA–ICG–PFTBA was 131.3 ± 1.08 nm. The in vitro 1O2 and ROS concentrations of the CCm–HSA–ICG–PFTBA group were both significantly higher than those of the other groups (P < 0.001). In vivo fluorescence imaging revealed that the best time window was at 24 h post-injection of the CCm–HSA–ICG–PFTBA. Both in vivo 18F-FMISO PET imaging and ex vivo immunofluorescence staining results exhibited that the tumor hypoxia was significantly improved at 24 h post-injection of the CCm–HSA–ICG–PFTBA. For in vivo PDT treatment, the tumor volume and weight of the CCm–HSA–ICG–PFTBA with NIR group were both the smallest among all the groups and significantly decreased compared to the untreated group (P < 0.01). No obvious biotoxicity was observed by the injection of CCm–HSA–ICG–PFTBA till 14 days. Conclusions By using the high oxygen solubility of perfluorocarbon (PFC) and the homologous targeting ability of cancer cell membranes, CCm–HSA–ICG–PFTBA can target tumor tissues, mitigate the hypoxia of the tumor microenvironment, and enhance the PDT efficacy in TNBC xenografts. Furthermore, the HSA, ICG, and PFC are all FDA-approved materials, which render the nanoparticles highly biocompatible and enhance the potential for clinical translation in the treatment of TNBC patients.

Photodynamic therapy in a cervico-uterine cancer cell line (HeLa) implanted in nu/nu mice

2001 ◽  
Author(s):  
Eva Ramon Gallegos ◽  
Salomon Hernandez Guitierrez ◽  
Leticia Garduno Siciliano ◽  
Jose L. Jiminez Perez ◽  
Aura J. Perez Zapata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Line ◽  
Cancer Cell ◽  
Uterine Cancer ◽  
Cancer Cell Line ◽  
Cell Line Hela ◽  
Line Hela

scholarly journals In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jigang Wang ◽  
Jianbin Zhang ◽  
Chong-Jing Zhang ◽  
Yin Kwan Wong ◽  
Teck Kwang Lim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Proteomic Profiling ◽  
Hct116 Colon Cancer Cell

scholarly journals Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line

1997 ◽  
Vol 76 (3) ◽  
pp. 312-317 ◽  
Author(s):  
SN Datta ◽  
R Allman ◽  
C Loh ◽  
M Mason ◽  
PN Matthews
Keyword(s):  
Bladder Cancer ◽  
Photodynamic Therapy ◽  
Cell Line ◽  
Mitomycin C ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Bladder Cancer Cell ◽  
Bladder Cancer Cell Line
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