Energy efficient Pfitzinger reaction: a novel strategy using a surfactant catalyst

2017 ◽  
Vol 41 (21) ◽  
pp. 12380-12383 ◽  
Author(s):  
Priyanka A. More ◽  
Ganapati S. Shankarling
Keyword(s):  
Carboxylic Acid ◽  
Energy Efficient ◽  
Synthetic Route ◽  
Pfitzinger Reaction ◽  
Ultrasound Assisted ◽  
Novel Strategy

A novel ultrasound assisted synthetic route catalysed by a surfactant for the synthesis of quinolone-4-carboxylic acid.

scholarly journals A Novel Strategy Towards the Asymmetric Synthesis of Orthogonally Funtionalised 2-N-Benzyl-N-α-methylbenzylamino- 5-carboxymethyl-cyclopentane-1-carboxylic acid.

Molecules ◽  
2004 ◽  
Vol 9 (5) ◽  
pp. 373-382 ◽  
Author(s):  
Narciso Garrido ◽  
Mohamed El Hammoumi ◽  
David Díez ◽  
Mercedes García ◽  
Julio Urones
Keyword(s):  
Carboxylic Acid ◽  
Asymmetric Synthesis ◽  
Novel Strategy

scholarly journals Application of Pfitzinger Reaction in Synthesis of Hetero Ring Annelated Quinoline Carboxylic Acid Derivatives

2016 ◽  
Vol 28 (6) ◽  
pp. 1177-1180
Author(s):  
Taruna Yadav ◽  
Neelam K. Yadav ◽  
Manju Yadav ◽  
Bhawani Singh ◽  
D. Kishore
Keyword(s):  
Carboxylic Acid ◽  
Pfitzinger Reaction ◽  
Quinoline Carboxylic Acid

A synthetic route to highly substituted ketones. Acylations of .alpha. anions of carboxylic acid salts with acid chlorides

1977 ◽  
Vol 42 (7) ◽  
pp. 1189-1194 ◽  
Author(s):  
A. Paul Krapcho ◽  
David S. Kashdan ◽  
E. G. E. Jahngen ◽  
A. J. Lovey
Keyword(s):  
Carboxylic Acid ◽  
Acid Chlorides ◽  
Synthetic Route ◽  
Acid Salts

scholarly journals Agro-industrial waste as a source of bioactive compounds: ultrasound-assisted extraction from blueberry (Vaccinium myrtillus) and raspberry (Rubus idaeus) pomace

2021 ◽  
Vol 43 ◽  
pp. e55564
Author(s):  
Suelen Siqueira dos Santos ◽  
Carolina Moser Paraíso ◽  
Letícia Misturini Rodrigues ◽  
Grasiele Scaramal Madrona
Keyword(s):  
Bioactive Compounds ◽  
Energy Efficient ◽  
Extraction Method ◽  
Rubus Idaeus ◽  
Total Phenolic ◽  
Ultrasound Assisted Extraction ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Conventional Extraction ◽  
Gallic Acid Equivalent

Blueberry and raspberry pomace are a rich source of bioactive compounds that have not been commercially utilized yet, and ultrasound-assisted technology can efficiently extract these compounds. Also, the use of water as a solvent added to the ultrasound-assisted technology improves this eco-friendly process. Therefore, an aqueous eco-friendly extraction, including extraction time and ultrasound presence or absence (conventional extraction) was performed in order to extract bioactive compounds from blueberry and raspberry pomace. Response parameters included levels of anthocyanins, phenolic compounds, and flavonoids, and antioxidant activity determined by DPPH, ABTS, and FRAP methods. Analysis of variance results indicated that ultrasound-assisted extraction for 45 min. was feasible to extract the bioactive compounds. The antioxidant content of the extract obtained by the ultrasound-assisted process was 1.4 times higher on average and the total phenolic concentration was 1.6 times higher (for blueberry 5.02 and for raspberry 2.53 mg gallic acid equivalent/g) compared with those obtained by the conventional process. Thus, the ultrasound-assisted extraction method can be a profitable alternative to extract bioactive compounds from blueberry and raspberry pomace, as it is energy efficient, requires fewer chemicals, and produces less effluent. This eco-friendly technology is therefore viable for food, nutraceutical, and cosmetic industries, and also for reducing food waste.

A new synthetic route to 7-halo-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, an intermediate for the synthesis of quinolone antibacterial agents

1987 ◽  
Vol 24 (1) ◽  
pp. 181-185 ◽  
Author(s):  
Hiroshi Egawa ◽  
Masahiro Kataoka ◽  
Koh-Ichiro Shibamori ◽  
Teruyuki Miyamoto ◽  
Junji Nakano ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Antibacterial Agents ◽  
Synthetic Route

scholarly journals The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis

2019 ◽  
Vol 116 (26) ◽  
pp. 12810-12815 ◽  
Author(s):  
James M. Clomburg ◽  
Shuai Qian ◽  
Zaigao Tan ◽  
Seokjung Cheong ◽  
Ramon Gonzalez
Keyword(s):  
Energy Efficient ◽  
Sole Carbon Source ◽  
Isoprenoid Biosynthesis ◽  
High Flux ◽  
Alternative Route ◽  
Synthetic Route ◽  
Isopentenyl Pyrophosphate ◽  
Commodity Chemicals ◽  
Central Carbon ◽  
Dimethylallyl Pyrophosphate

The more than 50,000 isoprenoids found in nature are all derived from the 5-carbon diphosphates isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Natively, IPP and DMAPP are generated by the mevalonate (MVA) and 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways, which have been engineered to produce compounds with numerous applications. However, as these pathways are inherently constrained by carbon, energy inefficiencies, and their roles in native metabolism, engineering for isoprenoid biosynthesis at high flux, titer, and yield remains a challenge. To overcome these limitations, here we develop an alternative synthetic pathway termed the isoprenoid alcohol (IPA) pathway that centers around the synthesis and subsequent phosphorylation of IPAs. We first established a lower IPA pathway for the conversion of IPAs to isoprenoid pyrophosphate intermediates that enabled the production of greater than 2 g/L geraniol from prenol as well as limonene, farnesol, diaponeurosporene, and lycopene. We then designed upper IPA pathways for the generation of (iso)prenol from central carbon metabolites with the development of a route to prenol enabling its synthesis at more than 2 g/L. Using prenol as the linking intermediate further facilitated an integrated IPA pathway that resulted in the production of nearly 0.6 g/L total monoterpenoids from glycerol as the sole carbon source. The IPA pathway provides an alternative route to isoprenoids that is more energy efficient than native pathways and can serve as a platform for targeting a repertoire of isoprenoid compounds with application as high-value pharmaceuticals, commodity chemicals, and fuels.

A new synthetic route to 2-hydroxynaphthalene-1-carboxylic acid derivatives. An efficient access to the naphthalene moiety of neocarzinostatin chromophore

Tetrahedron ◽  
1989 ◽  
Vol 45 (18) ◽  
pp. 5791-5804 ◽  
Author(s):  
Kozo Shishido ◽  
Akitake Yamashita ◽  
Kou Hiroya ◽  
Keiichiro Fukumoto ◽  
Tetsuji Kametani
Keyword(s):  
Carboxylic Acid ◽  
Synthetic Route ◽  
Efficient Access

scholarly journals A bio-facilitated synthetic route for nano-structured complex electrode materials

2016 ◽  
Vol 18 (9) ◽  
pp. 2619-2624 ◽  
Author(s):  
Maryam Moradi ◽  
Jae Chul Kim ◽  
Jifa Qi ◽  
Kang Xu ◽  
Xin Li ◽  
...  
Keyword(s):  
Solid State ◽  
Energy Efficient ◽  
Electrode Materials ◽  
Inorganic Materials ◽  
State Solution ◽  
Solid State Reactions ◽  
Synthetic Route ◽  
Efficient Synthesis ◽  
Wide Range

Bio-facilitated solid state solution: we investigate an energy-efficient synthesis that merges the bio-templated technique and solid-state reactions to produce a wide range of nano-structured complex inorganic materials.

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