Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

2017 ◽  
Vol 8 (45) ◽  
pp. 6938-6942 ◽  
Author(s):  
Daquan Wang ◽  
Yibo Ren ◽  
Yongping Shao ◽  
Lingjie Meng
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Photothermal Therapy ◽  
Normal Cells ◽  
Redox Responsive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

A multifunctional drug delivery system for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene onto multi-walled carbon nanotubes, which could selectively suppress and kill cancer cells, but negligibly affect normal cells.

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

2016 ◽  
Vol 4 (21) ◽  
pp. 3823-3831 ◽  
Author(s):  
Stefano Fedeli ◽  
Alberto Brandi ◽  
Lorenzo Venturini ◽  
Paola Chiarugi ◽  
Elisa Giannoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Multi Walled Carbon Nanotube ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Straightforward Approach

An efficient drug delivery system through a straightforward approach to multi-walled carbon nanotube decoration.

Single-walled and multi-walled carbon nanotubes based drug delivery system: Cancer therapy: A review

2015 ◽  
Vol 52 (3) ◽  
pp. 262 ◽  
Author(s):  
B Dineshkumar ◽  
K Krishnakumar ◽  
AR Bhatt ◽  
D Paul ◽  
J Cherian ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System

2021 ◽  
Vol 17 (9) ◽  
pp. 1711-1725
Author(s):  
Ru Zhang ◽  
Shang Luo ◽  
Lin-Kun Hao ◽  
Yun-Ying Jiang ◽  
Ying Gao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Rabbit Model ◽  
Order Kinetic ◽  
Thrombolytic Drug ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

In order to improve the therapeutic effect, prolong the action time and reduce the side effects of the first generation thrombolytic drug urokinase (UK), a novel UK/multi-walled carbon nanotubes (MWCNTs)-chitosan (CS)-arginine-glycine-aspartic acid (Arg-Gly-Asp) (RGD) drug delivery system was synthesized by chemical bonding/non covalent bond modification/ultrasonic dispersion. The results showed that the diameter of the UK/MWCNTs-CS-RGD drug delivery system was about 30–40 nm, there was a layer of UK was attached to the surface of the tube wall, and the distribution was relatively uniform. The average encapsulation efficiency was 83.10%, and the average drug loading was 12.81%. Interestingly, it also had a certain sustained-release effect, and its release law was best fitted by first-order kinetic equation. Moreover, the accelerated and long-term stability test results show that it had good stability. Compared with free UK, UK/MWCNTs-CS-RGD had thrombolytic effect in vitro. In addition, MTT experiment showed that the prepared MWCNTs-CS-RGD nanomaterials had good biocompatibility. A rabbit model of carotid artery thrombosis was used to conduct targeted thrombolysis experiments in vivo. Compared with free UK, UK/MWCNTs-CS-RGD could be enriched in the thrombosis site to achieve thrombus targeting. UK/MWCNTs-CS-RGD drug delivery system was expected to become an effective thrombolytic drug for targeted therapy of thrombosis.

The Use of Multi-Walled Carbon Nanotubes as Possible Carrier in Drug Delivery System for Aspirin

2009 ◽  
Author(s):  
Alias Mohd. Yusof ◽  
Nor Aziah Buang ◽  
Lee Sze Yean ◽  
Mohd. Lokman Ibrahim ◽  
Mohamad Rusop ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Invitro study of multiwall carbon nanotubes (MWCNTs) with adsorbed mitoxantrone (MTO) as a drug delivery system to treat breast cancer

RSC Advances ◽  
2014 ◽  
Vol 4 (36) ◽  
pp. 18683-18693 ◽  
Author(s):  
Giulia Risi ◽  
Nora Bloise ◽  
Daniele Merli ◽  
Antonia Icaro-Cornaglia ◽  
Antonella Profumo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiwall Carbon Nanotubes ◽  
System P ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Treat Breast Cancer

Mitoxantrone 600 dpi in TIF format)??>(MTO) is a well-known anticancer drug. In order to improve its therapeutic effect, multi-walled carbon nanotubes (MWCNTs) were studied in vitro as a drug delivery system.

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