scholarly journals Cinobufagin, a bufadienolide, activates ROS-mediated pathways to trigger human lung cancer cell apoptosis in vivo

RSC Advances ◽  
2017 ◽  
Vol 7 (40) ◽  
pp. 25175-25181 ◽  
Author(s):  
Panli Peng ◽  
Junhong Lv ◽  
Changqing Cai ◽  
Shaohuan Lin ◽  
Enqing Zhuo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Human Beings ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Common Malignancy

Lung cancer, as the most common malignancy worldwide, is one of the most threatening diseases for human beings.

scholarly journals Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

2013 ◽  
Vol 54 (11) ◽  
pp. 3116-3129 ◽  
Author(s):  
Robert Ramer ◽  
Udo Walther ◽  
Philipp Borchert ◽  
Stefan Laufer ◽  
Michael Linnebacher ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Cox 2

scholarly journals In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines

2013 ◽  
Vol 2 (1) ◽  
pp. 16 ◽  
Author(s):  
Ping Wang ◽  
Zhenhe Suo ◽  
Mengyu Wang ◽  
Hanne K Høifødt ◽  
Øystein Fodstad ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

TLR9 Signaling Promotes Tumor Progression of Human Lung Cancer Cell In Vivo

2009 ◽  
Vol 15 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Tao Ren ◽  
Lin Xu ◽  
Shuxian Jiao ◽  
Yanying Wang ◽  
Yingyun Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Progression ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Tlr9 Signaling

scholarly journals Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 10345-10362 ◽  
Author(s):  
Udo Walther ◽  
Kristin Emmrich ◽  
Robert Ramer ◽  
Nadine Mittag ◽  
Burkhard Hinz
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Cox 2 ◽  
Dependent Pathway

scholarly journals PRMT5 Promotes Human Lung Cancer Cell Apoptosis via Akt/Gsk3β Signaling Induced by Resveratrol

2019 ◽  
Vol 28 (12) ◽  
pp. 1664-1673 ◽  
Author(s):  
Yong Li ◽  
Yanxia Yang ◽  
Xiaoping Liu ◽  
Yiwen Long ◽  
Yonghua Zheng
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Down Regulation ◽  
Human Lung Cancer Cell ◽  
Cancer Cell Apoptosis

Protein arginine methyltransferase 5 (PRMT5) is implicated in various types of human cancer and tumor development, especially in lung cancer. Nevertheless, it is still unclear whether suppression of PRMT5 could promote lung cancer cell apoptosis and chemosensitivity induced by resveratrol, and the underlying molecular mechanism remains completely unknown. Here, we showed that PRMT5 was overexpressed in human lung cancer tissues and different types of lung cancer cell lines. Moreover, we constructed PRMT5 stable knockdown cell lines (A549 and ASCT-a-1) and investigated the roles of PRMT5 and the related signaling pathway in lung cancer cell apoptosis induced by resveratrol. Our results indicated that inhibition or down-regulation of PRMT5 by GSK591, a PRMT5-specific inhibitor, or shRNAs markedly enhanced cell apoptosis and chemosensitivity stimulated by resveratrol. Further investigation showed that inhibition or down-regulation of PRMT5 further reduced Akt/GSK3β phosphorylation and the downstream targets cyclin D1 and E1 expression upon resveratrol treatment. Our findings suggest that PRMT5 is a pivotal mediator for human lung cancer cell death induced by resveratrol, which also reveals that PRMT5 may serve as a new therapeutic target for the treatment of human lung cancer.

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