scholarly journals Erratum to: Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines

2017 ◽  
Vol 91 (6) ◽  
pp. 2495-2496 ◽  
Author(s):  
Ming-Ju Hsieh ◽  
Te-Lung Tsai ◽  
Yih-Shou Hsieh ◽  
Chau-Jong Wang ◽  
Hui-Ling Chiou
Keyword(s):  
Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Jnk Signaling ◽  
Human Lung Cancer Cell

scholarly journals PRMT5 Promotes Human Lung Cancer Cell Apoptosis via Akt/Gsk3β Signaling Induced by Resveratrol

2019 ◽  
Vol 28 (12) ◽  
pp. 1664-1673 ◽  
Author(s):  
Yong Li ◽  
Yanxia Yang ◽  
Xiaoping Liu ◽  
Yiwen Long ◽  
Yonghua Zheng
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Down Regulation ◽  
Human Lung Cancer Cell ◽  
Cancer Cell Apoptosis

Protein arginine methyltransferase 5 (PRMT5) is implicated in various types of human cancer and tumor development, especially in lung cancer. Nevertheless, it is still unclear whether suppression of PRMT5 could promote lung cancer cell apoptosis and chemosensitivity induced by resveratrol, and the underlying molecular mechanism remains completely unknown. Here, we showed that PRMT5 was overexpressed in human lung cancer tissues and different types of lung cancer cell lines. Moreover, we constructed PRMT5 stable knockdown cell lines (A549 and ASCT-a-1) and investigated the roles of PRMT5 and the related signaling pathway in lung cancer cell apoptosis induced by resveratrol. Our results indicated that inhibition or down-regulation of PRMT5 by GSK591, a PRMT5-specific inhibitor, or shRNAs markedly enhanced cell apoptosis and chemosensitivity stimulated by resveratrol. Further investigation showed that inhibition or down-regulation of PRMT5 further reduced Akt/GSK3β phosphorylation and the downstream targets cyclin D1 and E1 expression upon resveratrol treatment. Our findings suggest that PRMT5 is a pivotal mediator for human lung cancer cell death induced by resveratrol, which also reveals that PRMT5 may serve as a new therapeutic target for the treatment of human lung cancer.

scholarly journals Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom

Toxins ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 38 ◽  
Author(s):  
Irasema Oroz-Parra ◽  
Mario Navarro ◽  
Karla Cervantes-Luevano ◽  
Carolina Álvarez-Delgado ◽  
Guy Salvesen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Synthetic Peptide ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Glutathione and related enzyme activity in human lung cancer cell lines

1988 ◽  
Vol 58 (4) ◽  
pp. 437-440 ◽  
Author(s):  
J Carmichael ◽  
JB Mitchell ◽  
N Friedman ◽  
AF Gazdar ◽  
A Russo
Keyword(s):  
Lung Cancer ◽  
Enzyme Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Related Enzyme

Activation of the NF-kappaB p50/p65 Complex in Human Lung Cancer Cell Lines

1999 ◽  
Vol 46 (2) ◽  
pp. 185
Author(s):  
Hyung Seok Choi ◽  
Chul Gyu Yoo ◽  
Choon Taek Lee ◽  
Young Whan Kim ◽  
Sung Koo Han ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Nf Kappab
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