scholarly journals Comprehensive exploration of the anticancer activities of procaine and its binding with calf thymus DNA: a multi spectroscopic and molecular modelling study

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9083-9093 ◽  
Author(s):  
Mohd. Sajid Ali ◽  
Mohammad Abul Farah ◽  
Hamad A. Al-Lohedan ◽  
Khalid Mashay Al-Anazi
Keyword(s):  
Anticancer Activity ◽  
Molecular Modelling ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Anticancer Activities ◽  
Demethylating Agent ◽  
Calf Thymus ◽  
Ct Dna ◽  
Modelling Study

DNA demethylating agent procaine binds at the minor groove of ct-DNA and increases the anticancer activity of doxorubicin.

Caffeic acid binds to the minor groove of calf thymus DNA: A multi-spectroscopic, thermodynamics and molecular modelling study

2017 ◽  
Vol 98 ◽  
pp. 319-328 ◽  
Author(s):  
Tarique Sarwar ◽  
Hassan Mubarak Ishqi ◽  
Sayeed Ur Rehman ◽  
Mohammed Amir Husain ◽  
Yusra Rahman ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Molecular Modelling ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Study

scholarly journals DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Co(en)2(py)2]3+ and [Co(en)2(mepy)2]3+

2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Penumaka Nagababu ◽  
D. Aravind Kumar ◽  
Kotha Laxma Reddy ◽  
K. Ashwini Kumar ◽  
Md. B. Mustafa ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Plasmid Dna ◽  
Emission Spectroscopy ◽  
Calf Thymus Dna ◽  
Dna Melting ◽  
Viscosity Measurements ◽  
Pyridine Complexes ◽  
Calf Thymus ◽  
Ct Dna

Two novel cobalt(III) pyridine complexes (1)[Co(en)2(py)2]3+ and (2)[Co(en)2(mepy)2]3+ (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photocleavage. Results suggest that the two complexes bind to DNA via groove mode and complex 2 binds more strongly to CT DNA than complex 1. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm, cytotoxicity results of complexes are also showing anticancer activity.

Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA

2015 ◽  
Vol 11 (2) ◽  
pp. 522-531 ◽  
Author(s):  
Tarique Sarwar ◽  
Mohammed Amir Husain ◽  
Sayeed Ur Rehman ◽  
Hassan Mubarak Ishqi ◽  
Mohammad Tabish
Keyword(s):  
Molecular Modelling ◽  
In Silico ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Calf Thymus ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Ct Dna

Minor groove binding of esculetin with Ct-DNA was established by a series of in vitro experiments and in silico analyses.

Interaction of capsaicin with calf thymus DNA: A multi-spectroscopic and molecular modelling study

2017 ◽  
Vol 97 ◽  
pp. 392-402 ◽  
Author(s):  
Faizan Abul Qais ◽  
K.M. Abdullah ◽  
Md. Maroof Alam ◽  
Imrana Naseem ◽  
Iqbal Ahmad
Keyword(s):  
Molecular Modelling ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Study

Unravelling the interaction of pirenzepine, a gastrointestinal disorder drug, with calf thymus DNA: An in vitro and molecular modelling study

2017 ◽  
Vol 625-626 ◽  
pp. 1-12 ◽  
Author(s):  
Yusra Rahman ◽  
Shumaila Afrin ◽  
Mohammed Amir Husain ◽  
Tarique Sarwar ◽  
Abad Ali ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Gastrointestinal Disorder ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Study

Cu(ii)-induced twisting of the biphenyl core: exploring the effect of structure and coordination environment of biphenyl-based chiral copper(ii) complexes on interaction with calf-thymus DNA

2020 ◽  
Vol 44 (46) ◽  
pp. 20275-20284
Author(s):  
Soumen Ghosh ◽  
Mehebub Ali Khan ◽  
Arghyadeep Bhattacharyya ◽  
Md. Akhtarul Alam ◽  
Ennio Zangrando ◽  
...  
Keyword(s):  
Optically Active ◽  
Calf Thymus Dna ◽  
Coordination Environment ◽  
Calf Thymus ◽  
Ct Dna ◽  
Effect Of Structure

Biphenyl core-based clip-like receptors get twisted after complexation with Cu2+. The extent of interaction of the optically active complexes with ct-DNA varies depending on the structure and coordination environment.

Interaction of a synthesized pyrene based fluorescent probe with CT-DNA: spectroscopic, thermodynamic and molecular modeling studies

RSC Advances ◽  
2016 ◽  
Vol 6 (96) ◽  
pp. 93335-93342 ◽  
Author(s):  
Soumen Ghosh ◽  
Abdulla Al Masum ◽  
Aniruddha Ganguly ◽  
Md. Akhtarul Alam ◽  
Md. Maidul Islam ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Fluorescent Probe ◽  
Water Soluble ◽  
Calf Thymus Dna ◽  
Modeling Studies ◽  
Calf Thymus ◽  
Molecular Modeling Studies ◽  
Ct Dna

The present study demonstrates the synthesis of a new pyrene based water soluble fluorescent probe and its interaction with Calf-thymus DNA.

Spectroscopic and In Silico DNA Binding Studies on the Interaction of Some New N-Substituted Rhodanines with Calf-thymus DNA: In Vitro Anticancer Activities

2019 ◽  
Vol 19 (3) ◽  
pp. 425-433 ◽  
Author(s):  
Imran Ali ◽  
Mohammad N. Lone ◽  
Zeid A. Alothman ◽  
Ahmad Y. Badjah ◽  
Abdullah G. Alanazi
Keyword(s):  
Dna Binding ◽  
Anticancer Agents ◽  
In Silico ◽  
Calf Thymus Dna ◽  
Black Dot ◽  
Anticancer Activities ◽  
Binding Studies ◽  
Molecular Docking Study ◽  
Calf Thymus ◽  
Dna Binding Studies

Background: In this era of science, cancer is a black dot on the face of humankind. Consequently, the search of promising anticancer agents continues. Aims: Here we designed and synthesized new N-substituted rhodanines (RD1-7), evaluated their multispectroscopic interaction with calf thymus DNA, in silico and anticancer studies against MDA-MB-231cancer cell line. Methods: By MTT assay rhodanine RD1 was found to be the most potent with IC50 value of 72.61 μM. In addition, DNA binding studies (UV-vis and fluorescence) revealed strong binding affinity of RD1-7 with DNA (Kb in the range of 1.5-7.4 × 105 M-1). Moreover, molecular docking study, experimental DNA binding and anticancer studies are all well agreed to each other. Results: It was observed that H-bonding and hydrophobic attractions were responsible for stability of DNAcompound adducts. Besides, the reported rhodanines (RD1-7) were found as minor groove binders of DNA. Concisely, RD1-7 indicated promising pharmacological properties and hence, shows auspicious future for the development of novel anticancer agents. Conclusion: The reported rhodanines showed excellent anticancer properties. Therefore, the described rhodanines may be used as potential anticancer agents in the future.

scholarly journals ct-DNA Binding and Antibacterial Activity of Octahedral Titanium (IV) Heteroleptic (Benzoylacetone and Hydroxamic Acids) Complexes

2016 ◽  
Vol 2016 ◽  
pp. 1-11
Author(s):  
Raj Kaushal ◽  
Sheetal Thakur ◽  
Kiran Nehra
Keyword(s):  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Spectroscopic Technique ◽  
Calf Thymus Dna ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Intercalative Mode ◽  
Heteroleptic Complexes ◽  
Calf Thymus ◽  
Ct Dna

Five structurally related titanium (IV) heteroleptic complexes, [TiCl2(bzac)(L1–4)] and [TiCl3(bzac)(HL5)]; bzac = benzoylacetonate; L1–5 = benzohydroximate (L1), salicylhydroximate (L2), acetohydroximate (L3), hydroxyurea (L4), and N-benzoyl-N-phenyl hydroxylamine (L5), were used for the assessment of their antibacterial activities against ten pathogenic bacterial strains. The titanium (IV) complexes (1–5) demonstrated significant level of antibacterial properties as measured using agar well diffusion method. UV-Vis absorption spectroscopic technique was applied, to get a better insight into the nature of binding between titanium (IV) complexes with calf thymus DNA (ct-DNA). On the basis of the results of UV-Vis absorption spectroscopy, the interaction between ct-DNA and the titanium (IV) complexes is likely to occur through the same mode. Results indicated that titanium (IV) complex can bind to calf thymus DNA (ct-DNA) via an intercalative mode. The intrinsic binding constant (Kb) was calculated by absorption spectra by using Benesi-Hildebrand equation. Further, Gibbs free energy was also calculated for all the complexes.

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