Injectable bioactive akermanite/alginate composite hydrogels for in situ skin tissue engineering

The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. This review presents an overview of current wound care techniques including skin tissue engineering and biomaterials as a novel and promising approach. We highlight the plasticity and different roles of immune cells, in particular macrophages during various stages of skin wound healing. These aspects are pivotal to promote the regeneration of nonhealing wounds such as ulcers in diabetic patients. We believe that a better understanding of the intrinsic immunomodulatory features of stem cells in implantable skin substitutes will lead to new translational opportunities. This, in turn, will improve skin tissue engineering and regenerative medicine applications.

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Progress in studies of epidermal stem cells and their application in skin tissue engineering

Stem Cell Research & Therapy ◽

10.1186/s13287-020-01796-3 ◽

2020 ◽

Vol 11 (1) ◽

Cited By ~ 3

Author(s):

Ronghua Yang ◽

Shuai Yang ◽

Jingling Zhao ◽

Ximin Hu ◽

Xiaodong Chen ◽

...

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Skin Tissue ◽

Epidermal Stem Cells ◽

Skin Tissue Engineering

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PLGA-collagen-BPNS Bifunctional Composite Mesh for Photothermal Therapy of Melanoma and Skin Tissue Engineering

Journal of Materials Chemistry B ◽

10.1039/d1tb02366g ◽

2021 ◽

Author(s):

Linawati Sutrisno ◽

Huajian Chen ◽

Toru Yoshitomi ◽

Naoki Kawazoe ◽

Yingnan Yang ◽

...

Keyword(s):

Tissue Engineering ◽

Skin Cancer ◽

Cancer Cells ◽

Photothermal Therapy ◽

Glycolic Acid ◽

Composite Scaffold ◽

Skin Regeneration ◽

Skin Tissue ◽

Composite Mesh ◽

Skin Tissue Engineering

Treatment of melanoma requires not only the elimination of skin cancer cells but also skin regeneration to heal defects. To achieve this goal, bifunctional composite scaffold of poly(DL-lactic-co-glycolic acid) (PLGA),...

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Amniotic membrane and its epithelial and mesenchymal stem cells as an appropriate source for skin tissue engineering and regenerative medicine

Artificial Cells Nanomedicine and Biotechnology ◽

10.1080/21691401.2018.1458730 ◽

2018 ◽

Vol 46 (sup2) ◽

pp. 431-440 ◽

Cited By ~ 15

Author(s):

Behrouz Farhadihosseinabadi ◽

Mehrdad Farahani ◽

Tahereh Tayebi ◽

Ameneh Jafari ◽

Felor Biniazan ◽

...

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Regenerative Medicine ◽

Amniotic Membrane ◽

Skin Tissue ◽

Skin Tissue Engineering

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Skin Tissue Engineering: Application of Adipose-Derived Stem Cells

BioMed Research International ◽

10.1155/2017/9747010 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 28

Author(s):

Agnes S. Klar ◽

Jakub Zimoch ◽

Thomas Biedermann

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Stem Cell ◽

Engineering Application ◽

Stromal Vascular Fraction ◽

Skin Tissue ◽

Tissue Engineering Application ◽

Adipose Derived Stem Cells ◽

Skin Tissue Engineering ◽

Stem Cell Source

Perception of the adipose tissue has changed dramatically over the last few decades. Identification of adipose-derived stem cells (ASCs) ultimately transformed paradigm of this tissue from a passive energy depot into a promising stem cell source with properties of self-renewal and multipotential differentiation. As compared to bone marrow-derived stem cells (BMSCs), ASCs are more easily accessible and their isolation yields higher amount of stem cells. Therefore, the ASCs are of high interest for stem cell-based therapies and skin tissue engineering. Currently, freshly isolated stromal vascular fraction (SVF), which may be used directly without any expansion, was also assessed to be highly effective in treating skin radiation injuries, burns, or nonhealing wounds such as diabetic ulcers. In this paper, we review the characteristics of SVF and ASCs and the efficacy of their treatment for skin injuries and disorders.

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