PLGA-collagen-BPNS Bifunctional Composite Mesh for Photothermal Therapy of Melanoma and Skin Tissue Engineering

Author(s):  
Linawati Sutrisno ◽  
Huajian Chen ◽  
Toru Yoshitomi ◽  
Naoki Kawazoe ◽  
Yingnan Yang ◽  
...  

Treatment of melanoma requires not only the elimination of skin cancer cells but also skin regeneration to heal defects. To achieve this goal, bifunctional composite scaffold of poly(DL-lactic-co-glycolic acid) (PLGA),...

Biomaterials ◽  
2008 ◽  
Vol 29 (30) ◽  
pp. 4100-4107 ◽  
Author(s):  
Sangamesh G. Kumbar ◽  
Syam P. Nukavarapu ◽  
Roshan James ◽  
Lakshmi S. Nair ◽  
Cato T. Laurencin

Author(s):  
Zeynep Karahaliloğlu ◽  
Batur Ercan ◽  
Stanley Chung ◽  
Erik Taylor ◽  
Emir B. Denkbaş ◽  
...  

2017 ◽  
Vol 5 (18) ◽  
pp. 3315-3326 ◽  
Author(s):  
Yan Han ◽  
Yonghui Li ◽  
Qiongyu Zeng ◽  
Haiyan Li ◽  
Jinliang Peng ◽  
...  

Injectable bioactive SA/Aker hydrogels formed by crosslinking of bioactive ions, which recruit stem cells and enhance skin regeneration.


2018 ◽  
Author(s):  
Antonios Keirouz ◽  
Giuseppino Fortunato ◽  
Anthony Callanan ◽  
Norbert Radacsi

Scaffolds and implants used for tissue engineering need to be adapted for their mechanical properties with respect to their environment within the human body. Therefore, a novel composite for skin tissue engineering is presented by use of blends of Poly(vinylpyrrolidone) (PVP) and Poly(glycerol sebacate) (PGS) were fabricated via the needleless electrospinning technique. The formed PGS/PVP blends were morphologically, thermochemically and mechanically characterized. The morphology of the developed fibers related to the concentration of PGS, with high concentrations of PGS merging the fibers together plasticizing the scaffold. The tensile modulus appeared to be affected by the concentration of PGS within the blends, with an apparent decrease in the elastic modulus of the electrospun mats and an exponential increase of the elongation at break. Ultraviolet (UV) crosslinking of PGS/PVP significantly decreased and stabilized the wettability of the formed fiber mats, as indicated by contact angle measurements. In vitro examination showed good viability and proliferation of human dermal fibroblasts over the period of a week. The present findings provide important insights for tuning the elastic properties of electrospun material by incorporating this unique elastomer, as a promising future candidate for skin substitute constructs.


3 Biotech ◽  
2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Satyavrat Tripathi ◽  
Bhisham Narayan Singh ◽  
Divakar Singh ◽  
Gaurav kumar ◽  
Pradeep Srivastava

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