scholarly journals Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 118
Author(s):  
Shima Tavakoli ◽  
Marta A. Kisiel ◽  
Thomas Biedermann ◽  
Agnes S. Klar
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Wound Healing ◽  
Skin Wound ◽  
Skin Tissue ◽  
Diabetic Patients ◽  
Specific Cell ◽  
Skin Substitutes ◽  
Skin Wound Healing ◽  
Skin Tissue Engineering

The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. This review presents an overview of current wound care techniques including skin tissue engineering and biomaterials as a novel and promising approach. We highlight the plasticity and different roles of immune cells, in particular macrophages during various stages of skin wound healing. These aspects are pivotal to promote the regeneration of nonhealing wounds such as ulcers in diabetic patients. We believe that a better understanding of the intrinsic immunomodulatory features of stem cells in implantable skin substitutes will lead to new translational opportunities. This, in turn, will improve skin tissue engineering and regenerative medicine applications.

Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway

2020 ◽  
Vol 52 (10) ◽  
pp. 1102-1110
Author(s):  
Zhaodong Wang ◽  
Guangliang Zhang ◽  
Yingying Le ◽  
Jihui Ju ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Wound Healing ◽  
Estrogen Receptor ◽  
Signaling Pathway ◽  
Skin Wound ◽  
Skin Tissue ◽  
Skin Wound Healing ◽  
Skin Tissue Engineering ◽  
Cyclin A2

Abstract Skin epidermal stem cells (EpSCs) play an important role in wound healing. Quercetin is a phytoestrogen reported to accelerate skin wound healing, but its effect on EpSCs is unknown. In this study, we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms. We found that quercetin at 0.1~1 μM significantly promoted EpSC proliferation and increased the number of cells in S phase. The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue. Mechanistic studies showed that quercetin significantly upregulated the expressions of β-catenin, c-Myc, and cyclins A2 and E1. Inhibitor for β-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation. The β-catenin inhibitor XAV-939 suppressed quercetin-induced expressions of β-catenin, c-Myc, and cyclins A2 and E1. The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin. Pretreatment of EpSCs with estrogen receptor (ER) antagonist ICI182780, but not the G protein-coupled ER1 antagonist G15, reversed quercetin-induced cell proliferation and upregulation of β-catenin, c-Myc, and cyclin A2. Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of β-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation. As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering, quercetin is a useful reagent to expand EpSCs for basic research, skin wound treatment, and skin tissue engineering.

Mesenchymal stem cells' interaction with skin: Wound-healing effect on fibroblast cells and skin tissue

2010 ◽  
Vol 18 (6) ◽  
pp. 655-661 ◽  
Author(s):  
Young Keul Jeon ◽  
Yun Ho Jang ◽  
Dong Ryeol Yoo ◽  
Si Na Kim ◽  
Sang Koo Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Skin Wound ◽  
Skin Tissue ◽  
Fibroblast Cells ◽  
Skin Wound Healing ◽  
Healing Effect ◽  
Wound Healing Effect

scholarly journals Stem Cells for Skin Tissue Engineering and Wound Healing

2009 ◽  
Vol 37 (4-5) ◽  
pp. 399-421 ◽  
Author(s):  
Ming Chen ◽  
Melissa Przyborowski ◽  
Francois Berthiaume
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Wound Healing ◽  
Skin Tissue ◽  
Skin Tissue Engineering

scholarly journals Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

Polymers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1546
Author(s):  
Shaima Maliha Riha ◽  
Manira Maarof ◽  
Mh Busra Fauzi
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Cell Therapy ◽  
Synergistic Effect ◽  
Stem Cell Therapy ◽  
Skin Tissue ◽  
Therapeutic Effects ◽  
Skin Tissue Engineering

Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.

Prospective application of exosomes derived from adipose‐derived stem cells in skin wound healing: A review

2019 ◽  
Vol 19 (3) ◽  
pp. 574-581 ◽  
Author(s):  
He Qiu ◽  
Shuo Liu ◽  
Kelun Wu ◽  
Rui Zhao ◽  
Lideng Cao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Skin Wound ◽  
Adipose Derived Stem Cells ◽  
Skin Wound Healing ◽  
Prospective Application

scholarly journals Epidermal Stem Cells in Skin Wound Healing

2017 ◽  
Vol 6 (9) ◽  
pp. 297-307 ◽  
Author(s):  
Yuanyuan Li ◽  
Jamie Zhang ◽  
Jiping Yue ◽  
Xuewen Gou ◽  
Xiaoyang Wu
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Skin Wound ◽  
Epidermal Stem Cells ◽  
Skin Wound Healing

scholarly journals Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Azar Nourian Dehkordi ◽  
Fatemeh Mirahmadi Babaheydari ◽  
Mohammad Chehelgerdi ◽  
Shiva Raeisi Dehkordi
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Stem Cell ◽  
Therapeutic Strategies ◽  
Skin Tissue ◽  
Skin Tissue Engineering

scholarly journals The Role of Stem Cells During Scarless Skin Wound Healing

2014 ◽  
Vol 3 (4) ◽  
pp. 304-314 ◽  
Author(s):  
Michael Sung-Min Hu ◽  
Robert C. Rennert ◽  
Adrian McArdle ◽  
Michael T. Chung ◽  
Graham G. Walmsley ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Skin Wound ◽  
Skin Wound Healing

Silk fibroin–keratin based 3D scaffolds as a dermal substitute for skin tissue engineering

2015 ◽  
Vol 7 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Nandana Bhardwaj ◽  
Wan Ting Sow ◽  
Dipali Devi ◽  
Kee Woei Ng ◽  
Biman B. Mandal ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Silk Fibroin ◽  
Skin Tissue ◽  
Dermal Substitute ◽  
Skin Substitutes ◽  
3D Scaffolds ◽  
Skin Tissue Engineering ◽  
Dermal Tissue ◽  
Engineered Skin Substitutes

Development of highly vascular dermal tissue-engineered skin substitutes with appropriate mechanical properties and cellular cues is in need for significant advancement in the field of dermal reconstruction.

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