Facile synthesis of a metal–organic framework nanocarrier for NIR imaging-guided photothermal therapy

2018 ◽  
Vol 6 (11) ◽  
pp. 2918-2924 ◽  
Author(s):  
Yawei Li ◽  
Na Xu ◽  
Junli Zhou ◽  
Wenhe Zhu ◽  
Letian Li ◽  
...  

Near infrared Cy dye was efficiently embedded into zeolitic imidazolate framework-8 by a facile route for further using in the imaging-guided photothermal therapy.

2017 ◽  
Vol 5 (9) ◽  
pp. 1772-1778 ◽  
Author(s):  
Xiangjun Chen ◽  
Manjie Zhang ◽  
Shengnan Li ◽  
Lu Li ◽  
Lingyu Zhang ◽  
...  

A facile route was developed to fabricate PPy@MOF for dual-mode magnetic resonance/photoacoustic imaging and synergistic chemo-photothermal therapy.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Junfeng Huang ◽  
Zhourui Xu ◽  
Yihang jiang ◽  
Wing-cheung Law ◽  
Biqin Dong ◽  
...  

AbstractChemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.


Nano Letters ◽  
2019 ◽  
Vol 19 (10) ◽  
pp. 6772-6780 ◽  
Author(s):  
Xiaoran Deng ◽  
Shuang Liang ◽  
Xuechao Cai ◽  
Shanshan Huang ◽  
Ziyong Cheng ◽  
...  

2017 ◽  
Vol 5 (35) ◽  
pp. 18823-18830 ◽  
Author(s):  
Seung-Keun Park ◽  
Jin Koo Kim ◽  
Yun Chan Kang

Multishell structured metal selenide nanocubes, namely, Co/(NiCo)Se2 box-in-box structures with different shell compositions, were successfully synthesized by applying zeolitic imidazolate framework-67 (ZIF-67) as a template.


2018 ◽  
Vol 17 (2) ◽  
pp. 1175-1175 ◽  
Author(s):  
Hui Sun ◽  
Hengyuan Zhang ◽  
Huimin Mao ◽  
Bin Yu ◽  
Jian Han ◽  
...  

2019 ◽  
Vol 40 (16-17) ◽  
pp. 2204-2210 ◽  
Author(s):  
Shengyan Wang ◽  
Weihua Chen ◽  
Chunhuan Jiang ◽  
Lehui Lu

2020 ◽  
Vol 44 (3) ◽  
pp. 1021-1027
Author(s):  
Velayudham Sankar ◽  
Peramaiah Karthik ◽  
Bernaurdshaw Neppolian ◽  
Bitragunta Sivakumar

Herein, we report facile synthesis of various benzimidazoles and benzothiazoles by using the NH2-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield.


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