Enzyme-instructed self-assembly of a novel histone deacetylase inhibitor with enhanced selectivity and anticancer efficiency

2019 ◽  
Vol 7 (4) ◽  
pp. 1477-1485 ◽  
Author(s):  
Yang Gao ◽  
Congrou Zhang ◽  
Jinglin Chang ◽  
Cuihong Yang ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Self Assembly ◽  
Histone Deacetylase Inhibitor ◽  
Anticancer Efficacy ◽  
Deacetylase Inhibitor ◽  
Self Assembled ◽  
Enhanced Selectivity

A novel peptide-based prodrug molecule could be activated in situ via ALP catalysis and further self-assembled into a nanodrug with enhanced selectivity and anticancer efficacy.

scholarly journals Effects of a Novel Histone Deacetylase Inhibitor, N-(2-Aminophenyl) Benzamide, on a Reversible Hypertrophy Induced by Isoproterenol in In Situ Rat Hearts

2007 ◽  
Vol 104 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Yutaka Kitagawa ◽  
Yamato Tamura ◽  
Juichiro Shimizu ◽  
Chikako Nakajima-Takenaka ◽  
Shigeki Taniguchi ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Rat Hearts ◽  
Deacetylase Inhibitor
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