The amino side chains do matter: chemoselectivity in the one-pot three-component synthesis of 2-amino-4H-chromenes by supramolecular catalysis with amino-appended β-cyclodextrins (ACDs) in water

2016 ◽  
Vol 6 (12) ◽  
pp. 4283-4293 ◽  
Author(s):  
Yufeng Ren ◽  
Bo Yang ◽  
Xiali Liao
Keyword(s):  
Side Chains ◽  
One Pot ◽  
Supramolecular Catalysis ◽  
The One ◽  
First Time

The one-pot three-component synthesis of 2-amino-4H-chromenes was accomplished by supramolecular catalysis with well-designed amino-appended β-cyclodextrins (ACDs) in water, while the key role of amino side chains in chemoselectivity was determined for the first time.

The Role of Cuprous Oxide Seeds in the One-Pot and Seeded Syntheses of Copper Nanowires

Small ◽  
2014 ◽  
Vol 10 (9) ◽  
pp. 1771-1778 ◽  
Author(s):  
Shengrong Ye ◽  
Aaron R. Rathmell ◽  
Yoon-Cheol Ha ◽  
Adria R. Wilson ◽  
Benjamin J. Wiley
Keyword(s):  
Cuprous Oxide ◽  
Copper Nanowires ◽  
One Pot ◽  
The One

Comments on the updated recommendations of the American College of Rheumatology (ACR) for the treatment of gout. Lifestyle (part 2)

2021 ◽  
Vol 15 (2) ◽  
pp. 83-88
Author(s):  
M. S. Eliseev
Keyword(s):  
Body Weight ◽  
Food Habits ◽  
The Other ◽  
Obese Patients ◽  
American College Of Rheumatology ◽  
The Russian Federation ◽  
The One ◽  
Effective Drugs ◽  
First Time

Updated ACR recommendations for the treatment of gout concerning lifestyle are discussed. Factors related to a lifestyle, above all food habits, for many years were of leading importance in the treatment of patients with gout, even after application of effective drugs. The authors of the updated ACR recommendations for the first time offered to reconsider the role of environmental factors in the genesis of gout and objectively assess the possibility of its non-drug treatment. On the one hand, regardless of the activity of the disease, the need for restrictions of the alcohol, purine-rich products and fructose-containing beverages, as well as the decrease of body weight in obese patients and vitamin C usage unviability are confirmed. On the other hand, these recommendations are conditional. Their new version of ACR recommendations is significantly different from both its previous version and other international and national recommendations, including recommendations on the diagnosis and treatment of gout used in the Russian Federation.

scholarly journals The Figure of Distrust: Prince A.S. Menshikov in the Maritime Department during the Period of Reforms, 1826–1828

2020 ◽  
Vol 4 (3) ◽  
pp. 702-733
Author(s):  
Kseniya V. Donik
Keyword(s):  
Methodological Approach ◽  
The Other ◽  
General Situation ◽  
Functional Characteristics ◽  
Problem Context ◽  
Agent Based ◽  
The One ◽  
First Time ◽  
Official Records

The article considers the role of Prince A. Menshikov as a specific type of agent of supreme authority in the process of reforming the maritime administration. The problem context of reforms resulted from the involvement of the naval generals and officials in abuses, which was a consequence of nepotism and unrest in the navy. The involvement of sailors in the Decembrist revolt significantly affected the attitude of the tsar to the general situation in the naval environment. Distrustful of the existing naval administration, Nicholas I needed an intermediary who would implement his idea of the arrangement of the navy on the one hand, and provide him with an objective “impartial” account of maritime problems, on the other hand. As a result of that, Adjutant General Prince A. Menshikov, who had had nothing to do with the naval service earlier, joined the navy to become the monarch’s agent in charge of the naval issues in the bodies of autocratic authority. The objective of the article is to identify the functions of such an agent based on the example of the Maritime Department. The sources of the article include official records and personal documents, some of which are introduced into scientific circulation for the first time. The principal methodological approach to the problem under study is an attempt to bring the appointment of Menshikov beyond the scope of narrow departmental history which was based on the unmotivated decision of the emperor and to propose an interpretation of the events in the context of tsarist government via agents, which has already been described in historiography. The author makes a conclusion about the interconnection between the crisis in the naval department, the attitude of the supreme authority towards it, and the appearance of the monarch’s agent with a number of his own functional characteristics.

scholarly journals A Simple and Efficient Method for the Partial Synthesis of Pure (3R,3’S)-Astaxanthin from (3R,3’R,6’R)-Lutein and Lutein Esters via (3R,3’S)-Zeaxanthin and Theoretical Study of Their Formation Mechanisms

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1386 ◽  
Author(s):  
Eloy Rodríguez-deLeón ◽  
J. Jiménez-Halla ◽  
José Báez ◽  
M. Bah
Keyword(s):  
Health Risks ◽  
Density Functional ◽  
Human Consumption ◽  
Formation Mechanisms ◽  
Chemical Transformations ◽  
Partial Synthesis ◽  
One Pot ◽  
Commercial Source ◽  
The One ◽  
First Time

Carotenoids are natural compounds that have important roles in promoting and maintaining human health. Synthetic astaxanthin is a highly requested product by the aquaculture industry, but natural astaxanthin is not. Various strategies have been developed to synthesize this carotenoid. Nonetheless, these approaches have not only provided limited global yields, but its main commercial source also carries several health risks for humans. In this contribution, the one-pot base-catalyzed reaction of (3R,3’R,6’R)-lutein (1) esters has resulted in a successful isomerization process to easily obtain up to 95% meso-zeaxanthin (2), which in turn is oxidized to (3R,3’S)-astaxanthin (3) with a global yield of 68%. The same oxidation performed with UV irradiation (365 nm) for 5 min provided the highest global yield (76%). These chemical transformations have also been achieved with a significant reduction of the health risks associated with its potential human consumption. Furthermore, this is the first time only one of the configurational isomers has been obtained semisynthetically. The poorly understood formation mechanisms of these two compounds were also investigated using Density-Functional Theory (DFT) calculations. These theoretical studies revealed that the isomerization involves a base-catalyzed deprotonation at C-6’, followed by C-4’ protonation, while the oxidation occurs via free radical mechanisms.

On the use of uno in Colombian Spanish: the role of transitivity

2019 ◽  
Vol 12 (1) ◽  
pp. 35-64
Author(s):  
Luz Marcela Hurtado ◽  
Ivan Ortega-Santos
Keyword(s):  
Focus Of Attention ◽  
Future Research ◽  
Null Pronouns ◽  
Overt Pronouns ◽  
Colombian Spanish ◽  
The One ◽  
First Time ◽  
Two Bodies ◽  
Impersonal Pronoun

Abstract Our goal is to explore the intersection of two bodies of literature, namely, the one on impersonal constructions with an emphasis on uno ‘one’, and the one on the effect of transitivity and the focus of attention on the distribution of overt vs. null pronouns, where it has been shown that overt pronominal subjects are disfavored in transitive contexts as opposed to intransitive contexts. Through a variationist analysis of the expression of uno in Barranquilla, Colombia, in the PRESSEA-BARRANQUILLA corpus, we extend this line of inquiry to this impersonal pronoun and study in detail for the first time the effect of the various components of transitivity on the distribution of overt pronouns. Specifically, various transitivity parameters put forward by Hopper and Thompson are shown to correctly predict the distribution of uno, namely, number of participants and kinesis whereas sentence polarity, aspect and individuation of the object yield mixed results meriting future research.

Dual role of ethyl bromodifluoroacetate in the formation of fluorine-containing heteroaromatic compounds

2018 ◽  
Vol 54 (65) ◽  
pp. 8960-8963 ◽  
Author(s):  
Xingxing Ma ◽  
Shaoyu Mai ◽  
Yao Zhou ◽  
Gui-Juan Cheng ◽  
Qiuling Song
Keyword(s):  
Dual Role ◽  
Primary Amines ◽  
Cascade Process ◽  
One Pot ◽  
Heteroaromatic Compounds ◽  
First Time

An efficient one-pot cascade process via unprecedented quadruple cleavage of BrCF2COOEt with primary amines to afford valuable fluorine-containing heterocycles is described, in which BrCF2COOEt plays a dual role as a C1 synthon and a difluoroalkylating reagent for the first time.

scholarly journals BIROKRATISASI PENEGAKAN HAK ASASI MANUSIA PASCA REFORMASI MELALUI PEMBENTUKAN KEMENTERIAN URUSAN HAM DAN PENGUATAN KOMNAS HAM

Yurispruden ◽  
2019 ◽  
Vol 2 (2) ◽  
pp. 119
Author(s):  
Arasy Pradana A Azis
Keyword(s):  
Human Rights ◽  
Public Space ◽  
The State ◽  
National Commission ◽  
Role Of The State ◽  
National Human ◽  
The One ◽  
First Time ◽  
Executive Body

ABSTRACTThe Reformation then became a momentum for improving the issues of upholding human rights in Indonesia, where human rights matters formally entered into the division of power. On the one hand, for the first time, a ministry was formed specifically to deal with human rights matters. While outside the executive body, Law No. 39 of 1999 strengthens the position of the National Commission of Human Rights which has actually been established since 1993. This phenomenon then raises a problem statement, on how bureaucratization of human rights after Reformation is manifested through the establishment of the National Human Rights Commission and the Ministry of Human Rights. It was found that each institution gained legitimacy from political dynamics in a more democratic public space. Between the state ministries for human rights and the National Commission of Human Rights, the principle of check and balances was carried out in their role as an organ of the Indonesian bureaucracy. On the one hand, the state minister for human rights is an extension of the executive's hand in managing human rights matters. As a counterweight, the National Human Rights Commission carries out the role of the state auxiliary bodies to monitor the government’s human rights work.Keywords:    Politic of Law, Bureaucratization, Human Rigths, Ministry of Law and Human Rights Affairs, National Commission of Human Rights. ABSTRAKPeristiwa Reformasi menjadi momentum perbaikan urusan penegakan HAM di Indonesia, di mana urusan HAM secara formal masuk ke dalam pembagian kekuasaan negara. Di satu sisi, untuk pertama kalinya dibentuk satu kementerian yang secara khusus menangani urusan HAM. Sementara di luar lembaga eksekutif, Undang-Undang Nomor 39 Tahun 1999 menguatkan kedudukan Komisi Nasional Hak Asasi Manusia yang sejatinya telah terbentuk sejak tahun 1993. Fenomena ini kemudian menimbulkan satu rumusan permasalahan, yaitu bagaimana birokratisasi urusan HAM pasca reformasi termanifestasi melalui pembentukan Komnas HAM dan kementerian urusan HAM. Ditemukan bahwa masing-masing lembaga memperoleh legitimasi dari dinamika politik di ruang publik yang lebih demokratis. Antara kementerian negara urusan HAM dan Komnas HAM kemudian menjalankan prinsip check and balances dalam menjalankan perannya sebagai organ birokrasi Indonesia. Di satu sisi, kementerian negara urusan HAM merupakan perpanjangan tangan eksekutif untuk mengurus urusan HAM. Sebagai penyeimbang, Komnas HAM menjalankan peran sebagai state auxiliary bodies guna mengawasi kinerja HAM pemerintah.Kata Kunci: Politik Hukum, Birokratisasi, Hak Asasi Manusia, Kementerian Urusan HAM, Komnas HAM.

scholarly journals Motet “Jesu, Meine Freude” by Johann Sebastian Bach: Comparative Analysis of Editions of Musical Text

2021 ◽  
pp. 167-181
Author(s):  
Dmytro Savon
Keyword(s):  
Comparative Analysis ◽  
Johann Sebastian Bach ◽  
Historical Reconstruction ◽  
The Third ◽  
Choral Repertoire ◽  
History Of ◽  
Baroque Era ◽  
The One ◽  
First Time

Relevance and scientific novelty of the selected subject for the research. In the Ukrainian musicology, the motets written by Johann Bach were mainly studied from the compositional means standpoint, considering the system of polyphony, the role of chorale and fugue in dramaturgy as well as the composition of works. Scientists have not previously researched the motets performance specificity. Meanwhile, motets, particularly the one reviewed in the article “Jesu, meine Freude”, are among the most frequently performed works of the choral repertoire. For the first time in the Ukrainian musicology, three edited versions of the motet “Jesu, meine Freude” are analyzed from the standpoint of historically oriented performance. Based on the study of editors’ comments and source literature (mostly German), the question of compliance of the musical text with the task of performing reconstruction of the baroque vocal and choral style was studied. The aim of the article lies in the need to find out specificity of the editors’ interpretation of motet “Jesu, meine Freude” written by Johann Bach and suitability extent of different edited versions for the historical reconstruction of the vocal-choral style of the German Baroque. During the development of particular article, such methods were utilized: historical — the history of edited versions of “Jesu, meine Freude” motet was traced, comparative — the comparative analysis of three edited versions of motet “Jesu, meine Freude” written by Johann Bach (Franz Wulner, Konrad Ameln and Mykhailo Berdennykov) was completed. Main results and conclusions. According to the completed comparative analysis, the first two of the three considered edited versions are textual, while the third one is adopted for performing. Textual versions are characterized by the preservation of the composer’s text in the smallest details, including comments to clearly identify the extent of changes made by the editor in the text. The peculiarities of the version adopted for performing contain the large amount of remarks added by the editor, covering dynamic shades, strokes, tempo notation, etc. It is noted that the choice of version type is determined by performance goals: to perform the works of Johann Bach in an authentic manner, the conductor should focus on facsimile versions, and if they are absent (as in the case of the “Jesu, meine Freude” motet), the one should use textual type of edited versions. The version developed for performing cannot correspond to the authentic performing, as the first does not reflect specific tendencies of the time when it was created. It is specified that the conductor should be familiar with the peculiarities of fixing the means of performance in the musical text of the Baroque era.

First evidence of formation of stable DBU Zn-phthalocyanine complexes: synthesis and characterization

2005 ◽  
Vol 09 (07) ◽  
pp. 519-527 ◽  
Author(s):  
Roberta Del Sole ◽  
Agnese De Luca ◽  
Giuseppe Mele ◽  
Giuseppe Vasapollo
Keyword(s):  
Thermal Analysis ◽  
Axial Ligand ◽  
Synthesis And Characterization ◽  
One Pot ◽  
Strong Base ◽  
Pyridine Complex ◽  
The Stability ◽  
First Time ◽  
Complex Thermal Analysis

Novel Zn (II) phthalocyanine and naphthalocyanine DBU complexes have been prepared in a one-pot synthesis reacting phthalonitrile precursors with an excess of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). For the first time, it has been well evidenced that DBU played the role of coordinating axial ligand together with the well known role of strong base. Also, DBU complexes showed better solubility in organic solvents due to the coordination of the bulky axial DBU ligand, compared to the Zn (II) phthalocyanines and naphthalocyanines without coordinated DBU. The coordinating properties of DBU toward ZnPcs (DBU free) complexes have also been investigated along with the ZnPc (pyridine) complex. Thermal analysis results reflecting the stability of the synthesized complexes under air are also presented.

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