The growing applications of SuFEx click chemistry

2019 ◽  
Vol 48 (17) ◽  
pp. 4731-4758 ◽  
Author(s):  
A. S. Barrow ◽  
C. J. Smedley ◽  
Q. Zheng ◽  
S. Li ◽  
J. Dong ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Next Generation ◽  
Click Reactions ◽  
Generation Family ◽  
Sulfur Fluoride

SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions, geared towards the rapid and reliable assembly of functional molecules.

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

CuAAC click reactions for the design of multifunctional luminescent ruthenium complexes

2016 ◽  
Vol 45 (6) ◽  
pp. 2338-2351 ◽  
Author(s):  
Natalia Zabarska ◽  
Anne Stumper ◽  
Sven Rau
Keyword(s):  
Click Chemistry ◽  
Ruthenium Complexes ◽  
Click Reactions ◽  
Versatile Tool ◽  
Potential Applicability

CuAAC (Cu(i) catalyzed azide–alkyne cycloaddition) click chemistry has emerged as a versatile tool in the development of photoactive ruthenium complexes with multilateral potential applicability. Three general concepts for their synthesis and selected applications are discussed.

Perceived Parental Care and Next-Generation Family Members’ Succession Intentions: The Sequential-Mediating Role of General Self-Efficacy and Perceived Person-Job Fit

2021 ◽  
pp. 1-39
Author(s):  
Fei Zhu ◽  
Haibo Zhou
Keyword(s):  
Family Business ◽  
Self Efficacy ◽  
Parental Behavior ◽  
Family Members ◽  
Next Generation ◽  
Job Fit ◽  
Generation Family ◽  
Business Succession ◽  
General Self Efficacy ◽  
Family Business Succession

ABSTRACT Whereas the existing literature on the relationship between parental behavior and family business succession mainly focuses on parental behavior in the business domain, we highlight the importance of parental behavior in the family domain. Integrating attachment theory, the family business succession literature, and person-job fit literature, our study proposes a theoretical framework hypothesizing that general self-efficacy and perceived person-job fit mediate the association between perceived parental care (an underrepresented family-domain-specific parental behavior) and next-generation family members’ succession intentions. This framework is tested by data from two surveys and further verified by qualitative interviews of next-generation family members. Multivariate analysis results suggest that next-generation family members’ general self-efficacy and perceived person-job fit played a sequential-mediating role in the relationship between perceived parental care and next-generation family members’ succession intentions. Our interviews not only confirm these results but also reveal new insights, particularly into the specific Chinese context in the study of family business succession.

Effects of parental entrepreneurial performance on the mode of entrepreneurial entry by the next-generation family members: evidence from an emerging economy

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sarah Watiri Muigai ◽  
Edward Mungai ◽  
S. Ramakrishna Velamuri
Keyword(s):  
Small Business ◽  
Family Business ◽  
Family Members ◽  
Business Owners ◽  
Small Business Owners ◽  
Next Generation ◽  
Content Type ◽  
Entrepreneurial Entry ◽  
Generation Family ◽  
Formal Employment

PurposeThe purpose of the paper is to examine the effects of perceived parental entrepreneurial rewards, or PPERs (i.e. the offspring's perception of the degree of parental success in entrepreneurship), on the corporate venturing (CV) mode of entrepreneurial entry and the interaction effects of family business involvement (FBI) and formal employment on the association between PPER and CV by the next-generation family members.Design/methodology/approachA survey was administered to a sample of 738 small business owners in Kenya; of which, 440 small business owners were selected because they grew up in a family business context. A probit model was used to examine the main and interaction effects.FindingsPPERs significantly influenced CV. FBI improves the positive relationship whereas formal employment reduces the effects of PPER on CV.Practical implicationsFamilies in business need to improve conversations with their children to include discussions concerning the intrinsic and extrinsic rewards of running a family business, which may shape not only the entrepreneurial entry path of their offspring but also the willingness to establish businesses that may grow and lead to continuity of the family business of origin.Originality/valueThe study investigates the effect of being embedded in a business family in shaping the CV mode of entrepreneurial entry by the next-generation family members who may not, on the one hand, find independent own founding an attractive option and for whom, on the other hand, the succession mode of entry may not be an option.

scholarly journals Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors

2018 ◽  
Vol 6 (30) ◽  
pp. 4929-4936 ◽  
Author(s):  
Faraz Jivan ◽  
Natalia Fabela ◽  
Zachary Davis ◽  
Daniel L. Alge
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Chemistry ◽  
Bioactive Peptides ◽  
Poly Ethylene Glycol ◽  
Click Reactions ◽  
Peg Hydrogels ◽  
Poly Ethylene

A two-step, click chemistry approach to create user-defined hydrogels consisting of poly(ethylene glycol) and bioactive peptides without the use of multi-arm precursors for tissue engineering.

Modular synthesis of glycopolymers with well-defined sugar units in the side chain via Ugi reaction and click chemistry: hetero vs. homo

2016 ◽  
Vol 7 (25) ◽  
pp. 4263-4271 ◽  
Author(s):  
Lulu Xue ◽  
Xinhong Xiong ◽  
Kui Chen ◽  
Yafei Luan ◽  
Gaojian Chen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Ugi Reaction ◽  
Side Chain ◽  
Click Reactions ◽  
Modular Synthesis

Modularized glycopolymers were prepared via Ugi and click reactions, and used as models to investigate their binding abilities.

scholarly journals Facile synthesis of novel hybrid POSS biomolecules via “Click” reactions

RSC Advances ◽  
2017 ◽  
Vol 7 (59) ◽  
pp. 37474-37477 ◽  
Author(s):  
Youssef El Aziz ◽  
Nazia Mehrban ◽  
Peter G. Taylor ◽  
Martin A. Birchall ◽  
James Bowen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Yield ◽  
Facile Synthesis ◽  
Click Reactions

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield and click chemistry has been used to attach bio-oligomers.

scholarly journals Poly(A)-ClickSeq: click-chemistry for next-generation 3΄-end sequencing without RNA enrichment or fragmentation

2017 ◽  
Vol 45 (12) ◽  
pp. e112-e112 ◽  
Author(s):  
Andrew Routh ◽  
Ping Ji ◽  
Elizabeth Jaworski ◽  
Zheng Xia ◽  
Wei Li ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Next Generation
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