Involvement of autophagy in the beneficial effects of resveratrol in hepatic steatosis treatment. A comparison with energy restriction

2018 ◽  
Vol 9 (8) ◽  
pp. 4207-4215 ◽  
Author(s):  
I. Milton-Laskibar ◽  
L. Aguirre ◽  
U. Etxeberria ◽  
F. I. Milagro ◽  
J. A. Martínez ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Energy Restriction ◽  
Beneficial Effects

Involvement of autophagy in the liver delipidating effects of resveratrol and energy restriction.

scholarly journals Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering

2021 ◽  
Vol 18 (8) ◽  
pp. 4049
Author(s):  
Jukka Hintikka ◽  
Sanna Lensu ◽  
Elina Mäkinen ◽  
Sira Karvinen ◽  
Marjaana Honkanen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Insulin Signaling ◽  
Aromatic Amino Acids ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Branched Chain

We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (n = 10/group). Previously analyzed GM and fecal metabolites were biclustered to reduce data dimensionality and identify interpretable groups of co-occurring genera and metabolites. Based on our findings, biclustering provides a useful algorithmic method for capturing such joint signatures. On the HFD, XOS-supplemented rats showed lower number of adipose tissue crown-like structures, increased phosphorylation of AKT in liver and adipose tissue as well as lower expression of hepatic miRNAs. XOS-supplemented rats had more fecal glycine and less hypoxanthine, isovalerate, branched chain amino acids and aromatic amino acids. Several bacterial genera were associated with the metabolic signatures. In conclusion, the beneficial effects of XOS on hepatic steatosis involved decreased adipose tissue inflammation and likely improved insulin signaling, which were further associated with fecal metabolites and GM.

scholarly journals The Metabolic Impact and Beneficial Effects of Different Energy Restriction Protocols in Rats: An Alternative Health Plan

2021 ◽  
Vol 9 (s1) ◽  
Author(s):  
Khalifa El-Dawy ◽  
Amany I. Ahmed ◽  
Samar I. Sharsher ◽  
Mohamed Metwally ◽  
Ahmed Hamed Arisha
Keyword(s):  
Health Plan ◽  
Energy Restriction ◽  
Alternative Health ◽  
Beneficial Effects

Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis

2006 ◽  
Vol 0 (0) ◽  
pp. 061108012713001-??? ◽  
Author(s):  
Sanjaya K Satapathy ◽  
Puja Sakhuja ◽  
Veena Malhotra ◽  
Barjesh C Sharma ◽  
Shiv K Sarin
Keyword(s):  
Hepatic Steatosis ◽  
Beneficial Effects ◽  
Alcoholic Steatohepatitis

375 THE PNPLA3-I148M MUTATION INCREASES BOTH DELETERIOUS AND BENEFICIAL EFFECTS OF DIET ON ALANINE AMINOTRANSFERASE AND HEPATIC STEATOSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1272
Author(s):  
Vincent L. Chen ◽  
Xiaomeng Du ◽  
Samuel K. Handelman ◽  
Elizabeth Speliotes
Keyword(s):  
Hepatic Steatosis ◽  
Alanine Aminotransferase ◽  
Beneficial Effects

P250 BENEFICIAL EFFECTS ON WEIGHT GAIN, HEPATIC STEATOSIS AND EXPRESSION OF LIPOGENIC TARGET GENES IN A MURINE OBESITY MODEL AFTER IL-1 TYPE CYTOKINE INACTIVATION

2014 ◽  
Vol 60 (1) ◽  
pp. S148-S149
Author(s):  
J. Wohlfahrt ◽  
A. Fettelschoss ◽  
T. Kündig ◽  
H. Hermanns ◽  
B. Müllhaupt ◽  
...  
Keyword(s):  
Weight Gain ◽  
Hepatic Steatosis ◽  
Target Genes ◽  
Beneficial Effects

scholarly journals Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats

Nutrients ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 737 ◽  
Author(s):  
Iñaki Milton-Laskibar ◽  
Leixuri Aguirre ◽  
Alfredo Fernández-Quintela ◽  
Anabela Rolo ◽  
João Soeiro Teodoro ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Energy Restriction ◽  
Additive Effects

scholarly journals Experimental Outcomes of the Mediterranean Diet: Lessons Learned from the Predimed Randomized Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2991 ◽  
Author(s):  
Dicle Kargin ◽  
Laura Tomaino ◽  
Lluís Serra-Majem
Keyword(s):  
Mediterranean Diet ◽  
Controlled Trial ◽  
Scientific Evidence ◽  
Olive Tree ◽  
Energy Restriction ◽  
Lessons Learned ◽  
Long Term Effects ◽  
Beneficial Effects ◽  
The Mediterranean ◽  
Predimed Study

The Mediterranean Diet (MD) is, culturally and historically, the nutritional pattern shared by people living in the olive-tree growing areas of the Mediterranean basin. It is of great importance for its potential preventive effect against cardiovascular diseases (CVDs). The PREvención con DIeta MEDiterránea (PREDIMED) study, a Spanish multicentre randomised controlled trial (RCT), was designed to assess the long-term effects of the MD, without any energy restriction, on the incidence of CVD in individuals at high cardiovascular (CV) risk. Since its inception, it gave a great contribution to the available literature on the issue. It is well known that, in the field of the health sciences, RCTs provide the best scientific evidence. Thus, the aim of the present review is to analyse the results of the RCTs performed within the frame of the PREDIMED study. Our findings showed that MD has beneficial effects in the primary prevention of CVDs, diabetes and in the management of metabolic syndrome.

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