Development of cholate conjugated hybrid polymeric micelles for FXR receptor mediated effective site-specific delivery of paclitaxel

2018 ◽  
Vol 42 (20) ◽  
pp. 17021-17032 ◽  
Author(s):  
Sivaraj Mehnath ◽  
Mukherjee Arjama ◽  
Mariappan Rajan ◽  
Murugaraj Jeyaraj
Keyword(s):  
Cholic Acid ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Site Specific ◽  
Effective Delivery ◽  
Effective Site ◽  
Micelle System

The aim of the present study was to explore the tumor targeting potential of a cholic acid (CA) conjugated polymeric micelle system for the effective delivery of paclitaxel (PTX).

scholarly journals Light-responsive CO2 bubble-generating polymeric micelles for tumor cell ablation

MedChemComm ◽  
2017 ◽  
Vol 8 (2) ◽  
pp. 405-407 ◽  
Author(s):  
Yifan Zhang ◽  
Yuncai Guan ◽  
Sizhan Ge ◽  
Ahu Yuan ◽  
Jinhui Wu ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Cell Ablation ◽  
Micelle System

A polymeric micelle system decomposes into CO2 bubbles and ablates tumor cells without loading any drug.

Reduction-responsive disulfide linkage core-cross-linked polymeric micelles for site-specific drug delivery

2020 ◽  
Vol 11 (44) ◽  
pp. 7078-7086
Author(s):  
Gaizhen Kuang ◽  
Qingfei Zhang ◽  
Shasha He ◽  
Yanjuan Wu ◽  
Yubin Huang
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Specific Drug ◽  
Disulfide Linkage ◽  
Site Specific ◽  
Doxorubicin Delivery ◽  
Effective Site

Reduction-responsive disulfide linkage core-cross-linked polymeric micelles (CLM@DOX) were developed for effective site-specific doxorubicin delivery.

scholarly journals Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

2017 ◽  
Vol Volume 12 ◽  
pp. 8779-8799 ◽  
Author(s):  
Xiaomin Zhang ◽  
Yibo Wu ◽  
Min Zhang ◽  
Jing Mao ◽  
Yun Wu ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Polymeric Micelle ◽  
Sodium Cholate ◽  
Targeting Delivery ◽  
Micelle System

scholarly journals A novel polymeric micelle used for in vivo MR imaging tracking of neural stem cells in acute ischemic stroke

RSC Advances ◽  
2017 ◽  
Vol 7 (25) ◽  
pp. 15041-15052 ◽  
Author(s):  
Liejing Lu ◽  
Yong Wang ◽  
Minghui Cao ◽  
Meiwei Chen ◽  
Bingling Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Mr Imaging ◽  
Neural Stem Cells ◽  
Acute Ischemic Stroke ◽  
Cholic Acid ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Biodegradable Poly

Novel cationic polymeric micelles based on biodegradable poly(aspartic acid-dimethylethanediamine)–lysine–cholic acid were synthesized for in vivo tracking therapeutic stem cells using MRI.

Ligand-conjugated pH-sensitive polymeric micelles for the targeted delivery of gefitinib in lung cancers

RSC Advances ◽  
2015 ◽  
Vol 5 (89) ◽  
pp. 73184-73193 ◽  
Author(s):  
Shi-Jiang Wang ◽  
Zhi-Jun Huo ◽  
Kai Liu ◽  
Ning Yu ◽  
Yan Ma ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Lung Cancers ◽  
Effective Delivery

The aim of the present study was to investigate the tumor targeting potential of a mannose-conjugated pH-sensitive nanosystem for the effective delivery of gefitinib (Gnb) to lung cancers.

Facile synthesis of mesoporous TiO2 film templated by block copolymer for photocatalytic applications

2021 ◽  
Author(s):  
Olufemi Olatidoye ◽  
Daria Thomas ◽  
Bishnu Bastakoti
Keyword(s):  
Thin Film ◽  
Block Copolymer ◽  
Ethylene Oxide ◽  
Tio2 Thin Film ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Mesoporous Tio2 ◽  
Facile Synthesis ◽  
Vinyl Pyridine ◽  
Photocatalytic Applications

A facile synthesis of a mesoporous TiO2 thin film is reported using poly(styrene-2-vinyl pyridine-ethylene oxide) polymeric micelle as a synthetic template. As the Ti precursor strongly binds with polymeric micelles...

scholarly journals In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection

2019 ◽  
Vol 109 ◽  
pp. 779-787 ◽  
Author(s):  
Débora V.C. Mendonça ◽  
Grasiele S.V. Tavares ◽  
Daniela P. Lage ◽  
Tauane G. Soyer ◽  
Lívia M. Carvalho ◽  
...  
Keyword(s):  
Polymeric Micelle ◽  
Leishmania Amazonensis ◽  
Micelle System

Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system

2011 ◽  
Vol 149 (3) ◽  
pp. 299-306 ◽  
Author(s):  
Yiguang Wang ◽  
Tingyuan Yang ◽  
Xun Wang ◽  
Wenbing Dai ◽  
Jiancheng Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Tumor Vasculature ◽  
Polymeric Micelle ◽  
Micelle System

scholarly journals Sortase-mediated site-specific modification of interleukin-2 for the generation of a tumor targeting acetazolamide-cytokine conjugate

2020 ◽  
Author(s):  
Baptiste Gouyou ◽  
J Millul ◽  
A Villa ◽  
S Cazzamalli ◽  
D Neri ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Tumor Targeting ◽  
Interleukin 2 ◽  
Industrial Applications ◽  
Carbonic Anhydrase Ix ◽  
Site Specific ◽  
Tumor Bearing ◽  
Bioactive Proteins

1.AbstractSmall ligands specific to tumor-associated antigens can be used as alternatives to antibodies for the delivery of small payloads such as radionuclides, cytotoxic drugs and fluorophores. Their use as delivery moiety of bioactive proteins like cytokines remains largely unexplored. Here, we describe the preparation and in vivo characterization of the first small molecule-cytokine conjugate targeting carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma and hypoxia. Site-specific conjugation between interleukin-2 and acetazolamide was obtained by Sortase A-mediated transpeptidation. Binding of the conjugate to the cognate CAIX antigen was confirmed by surface plasmon resonance. The in vivo targeting of structures expressing carbonic anhydrase IX was assessed by biodistribution experiments in tumor bearing mice. Optimization of manufacturability and tumor targeting performance of acetazolamide-cytokine products will be required in order to enable industrial applications.Graphical abstract

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