Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy

Small ◽  
2018 ◽  
Vol 14 (14) ◽  
pp. 1703789 ◽  
Author(s):  
Zhao-Hua Miao ◽  
Lan-Xiang Lv ◽  
Kai Li ◽  
Pei-Ying Liu ◽  
Zhenglin Li ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Liquid Exfoliation ◽  
Theranostic Agent

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Ct Imaging ◽  
Core Shell ◽  
Theranostic Agents

PEGylated hollow gold nanoparticles for combined X-ray radiation and photothermal therapy in vitro and enhanced CT imaging in vivo

2019 ◽  
Vol 16 ◽  
pp. 195-205 ◽  
Author(s):  
Ru Wang ◽  
Junjie Deng ◽  
Dongsheng He ◽  
Ershuang Yang ◽  
Wenqian Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Ct Imaging ◽  
X Ray ◽  
Hollow Gold Nanoparticles ◽  
Enhanced Ct

Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

2016 ◽  
Vol 4 (23) ◽  
pp. 4216-4226 ◽  
Author(s):  
Du Li ◽  
Yongxing Zhang ◽  
Shihui Wen ◽  
Yang Song ◽  
Yueqin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Gold Nanostars

A theranostic nanoplatform for in vivo CT imaging and enhanced PTT of tumors is reported.

scholarly journals Untrasmall Bi2S3 nanodots for in vivo X-ray CT imaging-guided photothermal therapy of cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (47) ◽  
pp. 29672-29678 ◽  
Author(s):  
Zelun Li ◽  
Kelong Ai ◽  
Zhe Yang ◽  
Tianqi Zhang ◽  
Jianhua Liu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Real Time ◽  
Photothermal Therapy ◽  
Therapeutic Response ◽  
Ct Imaging ◽  
X Ray

Theranostic nanomedicine has shown tremendous promise for more effective and predictive cancer treatment by real-time mornitoring of the delivery of therapeutics to tumors and subsequent therapeutic response.

scholarly journals Imaging: PEGylated WS2Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy (Adv. Mater. 12/2014)

2014 ◽  
Vol 26 (12) ◽  
pp. 1794-1794 ◽  
Author(s):  
Liang Cheng ◽  
Jingjing Liu ◽  
Xing Gu ◽  
Hua Gong ◽  
Xiaoze Shi ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Theranostic Agent

A zeolitic imidazolate framework-8-based indocyanine green theranostic agent for infrared fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (23) ◽  
pp. 3914-3921 ◽  
Author(s):  
Tianzheng Wang ◽  
Siqi Li ◽  
Zhen Zou ◽  
Luo Hai ◽  
Xue Yang ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Zeolitic Imidazolate Framework ◽  
Theranostic Agent

A zeolitic imidazolate framework-8-based indocyanine green theranostic agent was constructed for fluorescence imaging and photothermal therapy of tumors in vivo.

Multifunctional Bismuth Nanoparticles as Theranostic Agent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy

2018 ◽  
Vol 1 (2) ◽  
pp. 820-830 ◽  
Author(s):  
Chunyu Yang ◽  
Chongshen Guo ◽  
Wei Guo ◽  
Xiaole Zhao ◽  
Shaoqin Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Bismuth Nanoparticles ◽  
Theranostic Agent ◽  
Nir Laser

scholarly journals Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yingying Zhang ◽  
Yongxue Zhang ◽  
Lianglan Yin ◽  
Xiaotian Xia ◽  
Fan Hu ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Near Infrared ◽  
Biomedical Application ◽  
Infrared Region ◽  
Ct Imaging ◽  
Targeted Imaging ◽  
Coupling Reactions ◽  
Theranostic Agent ◽  
Iodine 131

Introduction.Radiolabeled gold nanoparticles play an important role in biomedical application. The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrinαvβ3-expressing tumors.Methods.HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of bare GNRs for better biocompatibility, and c(RGDfK) peptides were conjugated onto the carboxyl terminal of GNR-PEG-COOH via EDC/NHS coupling reactions. The nanoconjugate was characterized, and131I was directly tagged on the surface of GNRs via AuI bonds for SPECT/CT imaging. We preliminarily studied the characteristics of the probe and its feasibility for tumor-targeting SPECT/CT imaging.Results.The[131I]GNR-PEG-cRGD probe was prepared in a simple and rapid manner and was stable in both PBS and fetal bovine serum. It targeted selectively and could be taken up by tumor cells mainly via integrinαvβ3-receptor-mediated endocytosis. In vivo imaging, biodistribution, and autoradiography results showed evident tumor uptake in integrinαvβ3-expressing tumors.Conclusions.These promising results showed that this smart nanoprobe can be used for angiogenesis-targeted SPECT/CT imaging. Furthermore, the nanoprobe possesses a remarkable capacity for highly efficient photothermal conversion in the near-infrared region, suggesting its potential as a multifunctional theranostic agent.

Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells

2015 ◽  
Vol 44 (6) ◽  
pp. 2771-2779 ◽  
Author(s):  
Yuxin Zhang ◽  
Bo Li ◽  
Yunjiu Cao ◽  
Jinbao Qin ◽  
Zhiyou Peng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Ct Imaging ◽  
Dual Model ◽  
Photothermal Treatment ◽  
Nir Absorption

The hydrophilic Na0.3WO3 nanorods showed intense NIR absorption and large HU value, and thus can be used as a promising multifunctional agent for CT imaging and photothermal treatment of cancer.

scholarly journals Engineered Exosomes-Based Photothermal Therapy with MRI/CT Imaging Guidance Enhances Anticancer Efficacy through Deep Tumor Nucleus Penetration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1593
Author(s):  
Min Yang ◽  
Xiaohui Wang ◽  
Fang Pu ◽  
Ying Liu ◽  
Jia Guo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Ct Imaging ◽  
Cancer Site ◽  
Control Group ◽  
Anticancer Efficacy ◽  
In Vivo Experiments ◽  
Actual Application

Exosomes, as natural nanovesicles, have become a spotlight in the field of cancer therapy due to their reduced immunogenicity and ability to overcome physiological barriers. However, the tumor targeting ability of exosomes needs to be improved before its actual application. Herein, a multiple targeted engineered exosomes nanoplatform was constructed through rare earth element Gd and Dy-doped and TAT peptide-modified carbon dots (CDs:Gd,Dy-TAT) encapsulated into RGD peptide engineered exosomes (Exo-RGD), which were used to enhance the effect of cancer imaging diagnosis and photothermal therapy. In vitro and in vivo experiments showed that the resulting CDs:Gd,Dy-TAT@Exo-RGD could effectively accumulate at cancer site with an increased concentration owing to the targeting peptides modification and exosomes encapsulation. The tumor therapy effects of mice treated with CDs:Gd,Dy-TAT@Exo-RGD were heightened compared with mice from the CDs:Gd,Dy control group. After intravenous injection of CDs:Gd,Dy-TAT@Exo-RGD into tumor-bearing mice, the temperature of tumors rose to above 50 °C under NIR irradiation and the localized hyperpyrexia induced by CDs could remarkably ablate tumors. The survival rate of the mice was 100% after 60 days. In addition, the CDs:Gd,Dy-TAT@Exo-RGD exhibited higher MRI/CT imaging contrast enhancement of tumor sites than that of CDs:Gd,Dy. Our study identified that engineered exosomes are a powerful tool for encapsulating multiple agents to enhance cancer theranostic efficiency and provide insight into precise personalized nanomedicine.

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