Dual-template cascade synthesis of highly multi-branched Au nanoshells with ultrastrong NIR absorption and efficient photothermal therapeutic intervention

2019 ◽  
Vol 7 (4) ◽  
pp. 598-610 ◽  
Author(s):  
Kexin Bian ◽  
Xuwu Zhang ◽  
Mengxue Yang ◽  
Liyao Luo ◽  
Lei Li ◽  
...  
Keyword(s):  
Therapeutic Intervention ◽  
Photothermal Therapy ◽  
Gold Nanoshells ◽  
Nir Absorption

A universal dual-template cascade strategy for the synthesis of multi-branched gold nanoshells with ultrastrong NIR absorption for tumor photothermal therapy.

A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

2019 ◽  
Vol 55 (73) ◽  
pp. 10940-10943 ◽  
Author(s):  
Yongchao Yan ◽  
Hao Fu ◽  
Jian Wang ◽  
Chuanrong Chen ◽  
Qi Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Weak Acid ◽  
Ph Responsive ◽  
Agent Based ◽  
Nir Absorption ◽  
Acid Environment

A photo-stable and reversible pH-responsive phenazine dye displayed an obvious NIR absorption in a weak acid environment of tumor. The dye assembled into nanoparticles was developed for photoacoustic imaging-guided photothermal therapy in mice.

scholarly journals Polypeptide-Based Gold Nanoshells for Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Shijun Sung ◽  
Ke Ding ◽  
...  
Keyword(s):  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Core Material ◽  
Infrared Light ◽  
Great Promise ◽  
Laser Exposure ◽  
Enhanced Absorption ◽  
Block Copolypeptide

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation of a novel class of gold nanoshells with cores composed of self-assembled block copolypeptide vesicles with photothermal properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) block copolypeptide vesicles coated with a thin layer of gold demonstrate enhanced absorption of light due to surface plasmon resonance (SPR) in the near-infrared range. We show that the polypeptide-based K60L20 gold nanoshells have low toxicity in the absence of laser exposure, significant heat generation upon exposure to near-infrared light, and, as a result, localized cytotoxicity within the region of laser irradiation in vitro. To gain a better understanding of our gold nanoshells in the context of photothermal therapy, we developed a comprehensive mathematical model for heat transfer and experimentally validated this model by predicting the temperature as a function of time and position in our experimental setup. This model can be used to predict which parameters of our gold nanoshells can be manipulated to improve heat generation for tumor destruction. To our knowledge, our results represent the first ever use of block copolypeptide vesicles as the core material of gold nanoshells.

scholarly journals Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)–Targeted Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Kevin Y. Chen ◽  
Shijun Sung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Metastatic Prostate Cancer ◽  
Gold Nanoshells ◽  
Infrared Light ◽  
Prostate Stem Cell Antigen ◽  
Prostate Cancer Cells ◽  
Cell Antigen

Currently, there is no curative treatment for advanced metastatic prostate cancer, and options, such as chemotherapy, are often nonspecific, harming healthy cells and resulting in severe side effects. Attaching targeting ligands to agents used in anticancer therapies has been shown to improve efficacy and reduce nonspecific toxicity. Furthermore, the use of triggered therapies can enable spatial and temporal control over the treatment. Here, we combined an engineered prostate cancer–specific targeting ligand, the A11 minibody, with a novel photothermal therapy agent, polypeptide-based gold nanoshells, which generate heat in response to near-infrared light. We show that the A11 minibody strongly binds to the prostate stem cell antigen that is overexpressed on the surface of metastatic prostate cancer cells. Compared to nonconjugated gold nanoshells, our A11 minibody-conjugated gold nanoshell exhibited significant laser-induced, localized killing of prostate cancer cells in vitro. In addition, we improved upon a comprehensive heat transfer mathematical model that was previously developed by our laboratory. By relaxing some of the assumptions of our earlier model, we were able to generate more accurate predictions for this particular study. Our experimental and theoretical results demonstrate the potential of our novel minibody-conjugated gold nanoshells for metastatic prostate cancer therapy.

scholarly journals Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide−Silica Core Suitable for Both MR Imaging and Photothermal Therapy

2007 ◽  
Vol 111 (17) ◽  
pp. 6245-6251 ◽  
Author(s):  
Xiaojun Ji ◽  
Ruping Shao ◽  
Andrew M. Elliott ◽  
R. Jason Stafford ◽  
Emilio Esparza-Coss ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Superparamagnetic Iron Oxide ◽  
Gold Nanoshells ◽  
Silica Core

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

Small ◽  
2016 ◽  
Vol 12 (30) ◽  
pp. 4103-4112 ◽  
Author(s):  
Liyao Luo ◽  
Yanhong Bian ◽  
Yanping Liu ◽  
Xuwu Zhang ◽  
Meili Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Antitumor Effect ◽  
Near Infrared ◽  
Gold Nanoshells

The synergistic effect of chemo-photothermal therapies in SN-38-loaded gold-nanoshell-based colorectal cancer treatment

Nanomedicine ◽  
2021 ◽  
Author(s):  
Shu-Jyuan Yang ◽  
Hsiao-Ting Huang ◽  
Chung-Huan Huang ◽  
Jui-An Pai ◽  
Chung-Hao Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Au Nps ◽  
Tumor Mouse Model ◽  
Tumor Clearance ◽  
Tumor Growth Suppression

Aim: 7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded gold nanoshells nanoparticles (HSP@Au NPs) were developed for combined chemo-photothermal therapy to treat colorectal cancer. Materials & methods: SN-38-loaded nanoparticles (HSP NPs) were prepared by the lyophilization-hydration method, and then developed into gold nanoshells. The nanoparticles were characterized and assessed for photothermal properties, cytotoxicity and hemocompatibility in vitro. In vivo anticancer activity was tested in a tumor mouse model. Results: The HSP@Au NPs (diameter 186.9 nm, zeta potential 33.4 mV) led to significant cytotoxicity in cancer cells exposed to a near-infrared laser. Moreover, the HSP@Au NP-mediated chemo-photothermal therapy displayed significant tumor growth suppression and disappearance (25% of tumor clearance rate) without adverse side effects in vivo. Conclusion: HSP@Au NPs may be promising in the treatment of colorectal cancer in the future.

Preparation of adenovirus-templated gold nanoshells and a study of their photothermal therapy efficacy

2015 ◽  
Vol 39 (5) ◽  
pp. 3608-3614 ◽  
Author(s):  
Weili Xue ◽  
Jing Zhou ◽  
Dawei Gao ◽  
Faming Gao ◽  
Zi Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Gold Nanoshells ◽  
Therapy Efficacy ◽  
Good Biocompatibility

Adenovirus-templated gold nanoshells not only show good biocompatibility but also have excellent photothermal therapy efficacy against tumors.

Direct to Tumor: Transarterial Administration of Gold Nanoshells with Enhanced Targeting and Photothermal Therapy

2017 ◽  
Vol 13 (7) ◽  
pp. 795-804 ◽  
Author(s):  
Tengchuang Ma ◽  
Longfei Tan ◽  
Haibo Shao ◽  
Tianlong Liu ◽  
Yang Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Gold Nanoshells
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