Drastic promotion of guanine oxidation via electron transfer in Ψ-type DNA

2019 ◽  
Vol 55 (53) ◽  
pp. 7695-7698 ◽  
Author(s):  
Shunsuke Sakurai ◽  
Mayu Esumi ◽  
Makiko Tanaka
Keyword(s):  
Electron Transfer ◽  
Guanine Oxidation ◽  
Crowded Environment

Drastic promotion of guanine oxidation was induced by not only intraduplex ET but also interduplex ET in Ψ-type DNA in a crowded environment using PEG.

Attenuation of guanine oxidation via DNA-mediated electron transfer in a crowded environment using small cosolutes

2018 ◽  
Vol 16 (36) ◽  
pp. 6695-6702 ◽  
Author(s):  
Makiko Tanaka ◽  
Takayuki Matsumoto ◽  
Hiroki Iida
Keyword(s):  
Electron Transfer ◽  
Molecular Crowding ◽  
Guanine Oxidation ◽  
Mediated Electron Transfer ◽  
Modified Oligonucleotide ◽  
Crowded Environment

Guanine oxidation induced by photoirradiation on a pyrene-modified oligonucleotide was investigated under molecular crowding using small cosolutes such as glycerol.

scholarly journals Thrombin-Binding Aptamer Quadruplex Formation: AFM and Voltammetric Characterization

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Victor Constantin Diculescu ◽  
Ana-Maria Chiorcea-Paquim ◽  
Ramon Eritja ◽  
Ana Maria Oliveira-Brett
Keyword(s):  
Electron Transfer ◽  
Surface Coverage ◽  
Pyrolytic Graphite ◽  
Oxidation Potential ◽  
Oxidation Peak ◽  
No Adsorption ◽  
Guanine Oxidation ◽  
Force Microscopy ◽  
Atomic Force ◽  
Quadruplex Formation

The adsorption and the redox behaviour of thrombin-binding aptamer (TBA) and extended TBA (eTBA) were studied using atomic force microscopy and voltammetry at highly oriented pyrolytic graphite and glassy carbon. The different adsorption patterns and degree of surface coverage were correlated with the sequence base composition, presence/absence of K+, and voltammetric behaviour of TBA and eTBA. In the presence of K+, only a few single-stranded sequences present adsorption, while the majority of the molecules forms stable and rigid quadruplexes with no adsorption. Both TBA and eTBA are oxidized and the only anodic peak corresponds to guanine oxidation. Upon addition of K+ions, TBA and eTBA fold into a quadruplex, causing the decrease of guanine oxidation peak and occurrence of a new peak at a higher potential due to the oxidation of G-quartets. The higher oxidation potential of G-quartets is due to the greater difficulty of electron transfer from the inside of the quadruplex to the electrode surface than electron transfer from the more flexible single strands.

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

2019 ◽  
Vol 55 (93) ◽  
pp. 14062-14065 ◽  
Author(s):  
Takumi Okuda ◽  
Yusuke Kawashima ◽  
Yuuya Kasahara ◽  
Tatsuya Takagi ◽  
Junpei Yamamoto ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Excess Electron ◽  
Transfer Efficiency ◽  
Guanine Oxidation ◽  
Mediated Electron Transfer ◽  
Reduction Efficiency ◽  
Modified Oligonucleotide

PipPyU and OMePyU enhance the reduction efficiency without oxidizing guanine in DNA-mediated electron transfer.

Guanine Oxidation by Electron Transfer: One- versus Two-Electron Oxidation Mechanism

ChemBioChem ◽  
2005 ◽  
Vol 7 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Adam Kupan ◽  
Aude Saulière ◽  
Sylvain Broussy ◽  
Christel Seguy ◽  
Geneviève Pratviel ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Oxidation Mechanism ◽  
Guanine Oxidation

Intramolecular Electrocatalysis of 8-Oxo-Guanine Oxidation:  Secondary Structure Control of Electron Transfer in Osmium-Labeled Oligonucleotides

2003 ◽  
Vol 42 (20) ◽  
pp. 6379-6387 ◽  
Author(s):  
Rebecca C. Holmberg ◽  
Mark T. Tierney ◽  
Patricia A. Ropp ◽  
Eric E. Berg ◽  
Mark W. Grinstaff ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Secondary Structure ◽  
Guanine Oxidation ◽  
Structure Control

Proton-Coupled Electron Transfer in Guanine Oxidation:  Effects of Isotope, Solvent, and Chemical Modification

2003 ◽  
Vol 107 (1) ◽  
pp. 372-378 ◽  
Author(s):  
Stephanie C. Weatherly ◽  
Ivana V. Yang ◽  
Paul A. Armistead ◽  
H. Holden Thorp
Keyword(s):  
Electron Transfer ◽  
Chemical Modification ◽  
Guanine Oxidation ◽  
Proton Coupled Electron Transfer

Evaluation of DNA-mediated electron transfer using a hole-trapping nucleobase under crowded conditions

2022 ◽  
Author(s):  
Yuuki Taketomi ◽  
Yuuki Yamaguchi ◽  
Shunsuke Sakurai ◽  
Makiko Tanaka
Keyword(s):  
Electron Transfer ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Hole Trapping ◽  
Mixed Solutions ◽  
Mediated Electron Transfer ◽  
Poly Ethylene ◽  
Modified Oligonucleotide ◽  
Crowded Environment

The effects of a crowded environment on DNA-mediated electron transfer were evaluated using a pyrene-modified oligonucleotide containing a hole-trapping nucleobase in poly(ethylene glycol) mixed solutions. Rapid decompositions of hole-trapping bases...

Product Analysis of GG-Specific Photooxidation of DNA via Electron Transfer:  2-Aminoimidazolone as a Major Guanine Oxidation Product

1998 ◽  
Vol 120 (29) ◽  
pp. 7373-7374 ◽  
Author(s):  
Katsuhito Kino ◽  
Isao Saito ◽  
Hiroshi Sugiyama
Keyword(s):  
Electron Transfer ◽  
Oxidation Product ◽  
Product Analysis ◽  
Guanine Oxidation

A light optical diffractometer for electron microscopical images operating in line

1978 ◽  
Vol 36 (1) ◽  
pp. 86-87
Author(s):  
P. Bonhomme ◽  
A. Beorchia
Keyword(s):  
Electron Microscopy ◽  
Electron Transfer ◽  
Electron Microscope ◽  
Image Converter ◽  
Coherent Light ◽  
Spatial Filters ◽  
Electron Image ◽  
Electron Microscopical ◽  
Working Parameters ◽  
Amorphous Part

We have already described (1.2.3) a device using a pockel's effect light valve as a microscopical electron image converter. This converter can be read out with incoherent or coherent light. In the last case we can set in line with the converter an optical diffractometer. Now, electron microscopy developments have pointed out different advantages of diffractometry. Indeed diffractogram of an image of a thin amorphous part of a specimen gives information about electron transfer function and a single look at a diffractogram informs on focus, drift, residual astigmatism, and after standardizing, on periods resolved (4.5.6). These informations are obvious from diffractogram but are usualy obtained from a micrograph, so that a correction of electron microscope parameters cannot be realized before recording the micrograph. Diffractometer allows also processing of images by setting spatial filters in diffractogram plane (7) or by reconstruction of Fraunhofer image (8). Using Electrotitus read out with coherent light and fitted to a diffractometer; all these possibilities may be realized in pseudoreal time, so that working parameters may be optimally adjusted before recording a micrograph or before processing an image.

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