para-Sulphonato-calix[n]arene capped silver nanoparticles challenge the catalytic efficiency and the stability of a novel human gut serine protease inhibitor

2019 ◽  
Vol 55 (61) ◽  
pp. 8935-8938 ◽  
Author(s):  
Nizar Akermi ◽  
Hela Mkaouar ◽  
Aicha Kriaa ◽  
Amin Jablaoui ◽  
Souha Soussou ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Gut Microbiota ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Catalytic Efficiency ◽  
Serine Protease Inhibitor ◽  
Human Gut ◽  
Pancreatic Elastase ◽  
Human Gut Microbiota ◽  
The Stability

Eubacterium saburreum serpin from human gut microbiota inhibits the pancreatic elastase associated with pancreatitis, inhibition is strongly increased by para-sulphonato-calix[8]arene silver nanoparticles.

scholarly journals Titanium Dioxide Nanoparticles Elicit Lower Direct Inhibitory Effect on Human Gut Microbiota Than Silver Nanoparticles

2019 ◽  
Vol 172 (2) ◽  
pp. 411-416 ◽  
Author(s):  
Richard T Agans ◽  
Alex Gordon ◽  
Saber Hussain ◽  
Oleg Paliy
Keyword(s):  
Silver Nanoparticles ◽  
Titanium Dioxide ◽  
Gut Microbiota ◽  
Titanium Dioxide Nanoparticles ◽  
Close Association ◽  
Community Diversity ◽  
Bacterial Cells ◽  
Human Gut ◽  
Human Gut Microbiota

Abstract Due to continued technological development, people increasingly come in contact with engineered nanomaterials (ENMs) that are now used in foods and many industrial applications. Many ENMs have historically been shown to possess antimicrobial properties, which has sparked concern for how dietary nanomaterials impact gastrointestinal health via microbial dysbiosis. We employed an in vitro Human Gut Simulator system to examine interactions of dietary nano titanium dioxide (TiO2) with human gut microbiota. Electron microscopy indicated a close association of TiO2 particles with bacterial cells. Addition of TiO2 to microbial communities led to a modest reduction in community density but had no impact on community diversity and evenness. In contrast, administration of known antimicrobial silver nanoparticles (NPs) in a control experiment resulted in a drastic reduction of population density. In both cases, communities recovered once the addition of nanomaterials was ceased. Constrained ordination analysis of community profiles revealed that simulated colonic region was the primary determinant of microbiota composition. Accordingly, predicted community functional capacity and measured production of short-chain fatty acids were not changed significantly upon microbiota exposure to TiO2. We conclude that tested TiO2 NPs have limited direct effect on human gut microbiota.

Formation of silver nanoparticles by human gut microbiota

2019 ◽  
Vol 651 ◽  
pp. 1489-1494 ◽  
Author(s):  
Naiyi Yin ◽  
Rui Gao ◽  
Brett Knowles ◽  
Jiasheng Wang ◽  
Pengfei Wang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Gut Microbiota ◽  
Human Gut ◽  
Human Gut Microbiota

scholarly journals Gingipains ofPorphyromonas gingivalisAffect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins

2016 ◽  
Vol 291 (36) ◽  
pp. 18753-18764 ◽  
Author(s):  
Karolina Plaza ◽  
Magdalena Kalinska ◽  
Oliwia Bochenska ◽  
Ulf Meyer-Hoffert ◽  
Zhihong Wu ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Serine Protease ◽  
Serine Protease Inhibitor ◽  
Tissue Inhibitor ◽  
The Stability ◽  
And Function

scholarly journals The enemy from within: a prophage ofRoseburia intestinalissystematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition

2019 ◽  
Author(s):  
Jeffrey K. Cornuault ◽  
Elisabeth Moncaut ◽  
Valentin Loux ◽  
Aurélie Mathieu ◽  
Harry Sokol ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Species Abundance ◽  
Antibiotic Use ◽  
Temporal Variations ◽  
Phage Resistance ◽  
Clear Understanding ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
The Stability ◽  
Selection Of

AbstractDespite an overall stability in time of the human gut microbiota at the phylum level, strong temporal variations in species abundance have been observed. We are far from a clear understanding of what promotes or disrupts the stability of microbiome communities. Environmental factors, like food or antibiotic use, modify the gut microbiota composition, but their overall impacts remain relatively low. Phages, the viruses that infect bacteria, might constitute important factors explaining temporal variations in species abundance. Gut bacteria harbour numerous prophages, or dormant viruses. A breakdown of prophage dormancy can evolve through the selection of ultravirulent phage mutants, potentially leading to important bacterial death. Whether such phenomenon occurs in the mammal’s microbiota has been largely unexplored.Here we studied temperate phage-bacteria coevolution in gnotoxenic mice colonised withEscherichia coliandRoseburia intestinalis, a dominant symbiont of the human gut microbiota. We show thatR. intestinalisharbors two active prophages, Jekyll and Shimadzu, and observed the systematic evolution of ultravirulent Shimadzu phage mutants, leading to a collapse ofR. intestinalispopulation. In a second step, phage infection drove the fast evolution of host phage-resistance mainly through phage-derived spacer acquisition in a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) array. Alternatively, phage resistance was conferred by a prophage originating from an ultravirulent phage with a restored ability to lysogenize.Our results demonstrate that prophages are the potential source of ultravirulent phages that can successfully infect most of the susceptible bacteria. This suggests that prophages can play important roles in the short-term temporal variations observed in the composition of the gut microbiota.

Itih-4, a serine protease inhibitor plays a prominent functional role in IL-6 induced hepatocyte formation

2001 ◽  
Vol 120 (5) ◽  
pp. A27-A28
Author(s):  
C BANUMATHY ◽  
Y TANG ◽  
B MISHRA ◽  
L MISHRA
Keyword(s):  
Protease Inhibitor ◽  
Serine Protease ◽  
Functional Role ◽  
Serine Protease Inhibitor

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark

Metabolization of the herbal combination STW-5 by human gut microbiota in vitro

2017 ◽  
Author(s):  
EM Pferschy-Wenzig ◽  
A Roßmann ◽  
K Koskinen ◽  
H Abdel-Aziz ◽  
C Moissl-Eichinger ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Human Gut ◽  
Human Gut Microbiota
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