scholarly journals Direct comparison of solution and solid phase synthesis of sequence-defined macromolecules

2019 ◽  
Vol 10 (28) ◽  
pp. 3859-3867 ◽  
Author(s):  
Joshua O. Holloway ◽  
Katharina S. Wetzel ◽  
Steven Martens ◽  
Filip E. Du Prez ◽  
Michael A. R. Meier
Keyword(s):  
Molecular Weight ◽  
Click Chemistry ◽  
High Molecular Weight ◽  
Multicomponent Reactions ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Sequence-defined macromolecules of high molecular weight are synthesised by the combination of click chemistry with multicomponent reactions. The synthesis is performed on solid phase as well as in solution to directly compare the two approaches.

Facile one-step solid-phase synthesis of multitopic organic–DNA hybrids via “click” chemistry

2014 ◽  
Vol 5 (3) ◽  
pp. 1091-1096 ◽  
Author(s):  
Ryan V. Thaner ◽  
Ibrahim Eryazici ◽  
Omar K. Farha ◽  
Chad A. Mirkin ◽  
SonBinh T. Nguyen
Keyword(s):  
Click Chemistry ◽  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
One Pot ◽  
Phase Synthesis ◽  
One Step

Small molecule–DNA hybrids can be synthesized in a one-pot fashion and in good yields by coupling multiazide cores to alkyne-modified DNAs on a solid support using click chemistry.

Solid-Phase Synthesis of PEGylated Lipopeptides Using Click Chemistry

2010 ◽  
Vol 21 (5) ◽  
pp. 807-810 ◽  
Author(s):  
Rasmus I. Jølck ◽  
Rolf H. Berg ◽  
Thomas L. Andresen
Keyword(s):  
Click Chemistry ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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