Rh-Catalyzed C–C/C–N bond formation via C–H activation: synthesis of 2H-indazol-2-yl-benzo[a]carbazoles

2019 ◽  
Vol 6 (23) ◽  
pp. 3885-3890 ◽  
Author(s):  
Sundaravel Vivek Kumar ◽  
Sonbidya Banerjee ◽  
Tharmalingam Punniyamurthy
Keyword(s):  
Ring Opening ◽  
Bond Formation ◽  
Mechanistic Studies ◽  
Site Selective

Rh-Catalyzed site-selective C–H activation and ring opening/cyclization of 7-azabenzonorbornadienes with aryl-2H-indazoles is developed to furnish indazolyl-benzocarbazole frameworks. Substrate scope and mechanistic studies are important practical features.

Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes

2019 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Mingbin Yuan ◽  
Chris Acha ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Mechanistic Studies ◽  
Radical Intermediates ◽  
Design And Implementation ◽  
Solvent Cage ◽  
Radical Cascade ◽  
Radical Processes

Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven approach. Mechanistic studies support the diffusion of the alkyl radical intermediates out of the solvent cage to participate in an intra- or -intermolecular radical cascade with the VCP followed by re-entering the Fe radical cross-coupling cycle to undergo selective C(sp2)-C(sp3) bond formation. Overall, we provide new design principles for Fe-mediated radical processes and underscore the potential of using combined computations and experiments to accelerate the development of challenging transformations.

Recent Advances in C–Br Bond Formation

Synlett ◽  
2021 ◽  
Author(s):  
Ying-Yeung Yeung ◽  
Jonathan Wong
Keyword(s):  
Organic Synthesis ◽  
Aromatic Compounds ◽  
Bond Formation ◽  
Cross Coupling ◽  
Catalytic Site ◽  
Atom Transfer ◽  
Bond Forming ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

A Site‐Selective C−N Bond Formation of 2,4‐Dichloro‐5 H ‐pyrano[2,3‐ d ]pyrimidines and Amide

2021 ◽  
Vol 6 (43) ◽  
pp. 12032-12035
Author(s):  
Jinjing Qin ◽  
Zhenhua Li ◽  
Yingyan Cao ◽  
Yuanyuan Xie ◽  
Weike Su
Keyword(s):  
Bond Formation ◽  
A Site ◽  
Site Selective

Mechanistic Studies on the Base-Promoted Ring Opening of Glycal-Derived gem-Dibromocyclopropanes

2021 ◽  
Author(s):  
Romain J. Lepage ◽  
Peter W. Moore ◽  
Russell J. Hewitt ◽  
Paul H. Teesdale-Spittle ◽  
Elizabeth H. Krenske ◽  
...  
Keyword(s):  
Ring Opening ◽  
Mechanistic Studies

scholarly journals Rhodium(III)‐Catalyzed Synthesis of N ‐(2‐Acetoxyalkyl)isoquinolones from Oxazolines and Alkynes through C−N Bond Formation and Ring‐Opening

2018 ◽  
Vol 361 (1) ◽  
pp. 214-218 ◽  
Author(s):  
Zi Yang ◽  
Lianghua Jie ◽  
Zhenyu Yao ◽  
Zhimin Yang ◽  
Xiuling Cui
Keyword(s):  
Ring Opening ◽  
Bond Formation
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