Facile phase transfer of hydrophobic Fe3O4@Cu2−xS nanoparticles by red blood cell membrane for MRI and phototherapy in the second near-infrared window

2020 ◽  
Vol 8 (6) ◽  
pp. 1202-1211 ◽  
Author(s):  
Kecan Lin ◽  
Yanbing Cao ◽  
Dongye Zheng ◽  
Qin Li ◽  
Hui Liu ◽  
...  

Theranostic agents for MRI and NIR II phototherapy by using red blood cell membrane for phase transfer of Fe3O4@Cu2−xS nanoparticles.

2019 ◽  
Vol 55 (46) ◽  
pp. 6523-6526 ◽  
Author(s):  
Zhou Liu ◽  
Jinquan Wang ◽  
Kangqiang Qiu ◽  
Xinxing Liao ◽  
Thomas W. Rees ◽  
...  

Cu2−xSe nanoparticles (Cu2−xSeNPs) were camouflaged with a red blood cell membrane (RBC) for synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR II) window.


2020 ◽  
Vol 56 (25) ◽  
pp. 3697-3697
Author(s):  
Zhou Liu ◽  
Jinquan Wang ◽  
Kangqiang Qiu ◽  
Xinxing Liao ◽  
Thomas W. Rees ◽  
...  

Correction for ‘Fabrication of red blood cell membrane-camouflaged Cu2−xSe nanoparticles for phototherapy in the second near-infrared window’ by Zhou Liu et al., Chem. Commun., 2019, 55, 6523–6526.


2016 ◽  
Vol 4 (23) ◽  
pp. 4191-4197 ◽  
Author(s):  
Xi Guo ◽  
Yanwen Zhang ◽  
Jianbo Liu ◽  
Xiaohai Yang ◽  
Jin Huang ◽  
...  

A biomimetic route to fusion of hydrophobic quantum dots (QDs) with living cells for membrane imaging was proposed. Red blood cell membrane lipids acted as both an efficient surfactant to phase-transfer QDs and a fusion reagent to facilitate fusion with cell membranes.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.


2001 ◽  
Vol 81 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Guillaume Lenormand ◽  
Sylvie Hénon ◽  
Alain Richert ◽  
Jacqueline Siméon ◽  
François Gallet

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