Conductive and antimicrobial macroporous nanocomposite hydrogels generated from air-in-water Pickering emulsions for neural stem cell differentiation and skin wound healing

2020 ◽  
Vol 8 (24) ◽  
pp. 6957-6968
Author(s):  
Mingjian Xu ◽  
Qingtao Li ◽  
Zhou Fang ◽  
Min Jin ◽  
Qing Zeng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Stem Cell Differentiation ◽  
Skin Wound ◽  
Pickering Emulsions ◽  
Skin Wound Healing ◽  
Soft Tissue Regeneration ◽  
Nanocomposite Hydrogels

Conductive and antimicrobial macroporous hydrogels have shown promising applications in promoting soft tissue regeneration.

Mapping the dominant wound healing and soft tissue regeneration QTL in MRL × CAST

2005 ◽  
Vol 16 (12) ◽  
pp. 918-924 ◽  
Author(s):  
Hongrun Yu ◽  
Subburaman Mohan ◽  
Godfred L. Masinde ◽  
David J. Baylink
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

Adipose stem cell-based soft tissue regeneration

2011 ◽  
Vol 12 (2) ◽  
pp. 155-163 ◽  
Author(s):  
Brian J Philips ◽  
Kacey G Marra ◽  
J Peter Rubin
Keyword(s):  
Stem Cell ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Adipose Stem Cell ◽  
Soft Tissue Regeneration

Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats

2011 ◽  
Vol 93 (2) ◽  
pp. 228-234 ◽  
Author(s):  
Mohsen Khosravi Maharlooei ◽  
Mansooreh Bagheri ◽  
Zhabiz Solhjou ◽  
Behnam Moein Jahromi ◽  
Majid Akrami ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Skin Wound ◽  
Diabetic Rats ◽  
Skin Wound Healing

Amelogenins and their effects on the wound healing of skin and oral mucous membrane

2018 ◽  
Vol 1 (1) ◽  
pp. 31-36
Author(s):  
Sylwia Klewin‑Steinböck ◽  
Marzena Wyganowska‑Świątkowska
Keyword(s):  
Wound Healing ◽  
Mucous Membrane ◽  
Tissue Regeneration ◽  
Degradation Products ◽  
Skin Wound ◽  
Periodontal Surgery ◽  
Skin Wound Healing ◽  
Guide Tissue Regeneration ◽  
Oral Mucous Membrane ◽  
Enamel Mineralization

Amelogenins are a mixture of hydrophobic proteins that are the major organic components of developing enamel. The main functions of the amelogenins and their degradation products are structural roles in creating the space and environment for promoting enamel mineralization. They are used in periodontal surgery to guide tissue regeneration. Based on clinical evidences that amelogenins positively affect the healing of periodontium tissue new application for amelogenins have been suggested. Conducted research confirmed that amelogenins can be used in skin wound healing.

scholarly journals Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo

2016 ◽  
Vol 113 (21) ◽  
pp. E2935-E2944 ◽  
Author(s):  
Xiaochen Zhou ◽  
Mingjia Tan ◽  
Mukesh K. Nyati ◽  
Yongchao Zhao ◽  
Gongxian Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Human Cancer ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Skin Wound Healing ◽  
Tumor Sphere ◽  
Sphere Formation

MLN4924, also known as pevonedistat, is the first-in-class inhibitor of NEDD8-activating enzyme, which blocks the entire neddylation modification of proteins. Previous preclinical studies and current clinical trials have been exclusively focused on its anticancer property. Unexpectedly, we show here, to our knowledge for the first time, that MLN4924, when applied at nanomolar concentrations, significantly stimulates in vitro tumor sphere formation and in vivo tumorigenesis and differentiation of human cancer cells and mouse embryonic stem cells. These stimulatory effects are attributable to (i) c-MYC accumulation via blocking its degradation and (ii) continued activation of EGFR (epidermal growth factor receptor) and its downstream pathways, including PI3K/AKT/mammalian target of rapamycin and RAS/RAF/MEK/ERK, via inducing EGFR dimerization. Finally, MLN4924 accelerates EGF-mediated skin wound healing in mouse and stimulates cell migration in an in vitro culture setting. Taking these data together, our study reveals that neddylation modification could regulate stem cell proliferation and differentiation and that a low dose of MLN4924 might have a therapeutic value for stem cell therapy and tissue regeneration.

scholarly journals Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization

2021 ◽  
Author(s):  
Yao Liu ◽  
Xueying Zhuang ◽  
Si Yu ◽  
Ning Yang ◽  
Jianhong Zeng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Cell Migration ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration ◽  
Apical Papilla ◽  
Craniofacial Tissue

Abstract Background: Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration is crucial in determining the therapeutic outcomes of craniofacial CSD. Stem cells from apical papilla (SCAP) are neural crest-derived mesenchymal stem cells (MSCs) that are homologous to cells in craniofacial tissue and represent a promising source for craniofacial tissue regeneration. Exosomes, which contain compound bioactive compounds, are the key factors in stem cell paracrine action. However, the roles of exosomes derived from SCAP (SCAP-Exo) in tissue regeneration are not fully understood. Here, we explored the effects and underlying mechanisms of SCAP-Exo on CSD in maxillofacial soft tissue. Methods: SCAP-Exo were isolated and identified by transmission electron microscopy and nanoparticle tracking analysis. The effects of SCAP-Exo on wound healing and vascularization were detected by measuring the wound area and performing histological and immunofluorescence analysis on the palatal gingival CSD of mice. Real-time live cell imaging and functional assays were used to assess the effects of SCAP-Exo on the biological functions of endothelial cells (ECs). Furthermore, the molecular mechanisms of SCAP-Exo-mediated EC angiogenesis in vitro were tested by immunofluorescence staining, Western blot and pull-down assays. Finally, in vivo experiments were carried out to verify whether SCAP-Exo could affect vascularization and wound healing through cell division cycle 42 (Cdc42). Results: We found that SCAP-Exo promoted tissue regeneration of palatal gingival CSD by enhancing vascularization in the early phase in vivo and that SCAP-Exo improved the angiogenic capacity of ECs in vitro . Mechanistically, SCAP-Exo elevated cell migration by improving cytoskeletal reorganization of ECs via Cdc42 signalling. Furthermore, we revealed that SCAP-Exo transferred Cdc42 into the cytoplasm of ECs and that the Cdc42 protein could be reused directly by recipient ECs, which resulted in the activation of Cdc42-dependent filopodium formation and elevation in cell migration of ECs. Conclusion: This study demonstrated that SCAP-Exo had a superior effect on angiogenesis and effectively promoted craniofacial soft tissue regeneration. These data provide a new option for SCAP-Exo to be used in a cell-free approach to optimize tissue regeneration in the clinic.

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