An ‘on-demand’ photothermal antibiotic release cryogel patch: evaluation of efficacy on an ex vivo model for skin wound infection

2020 ◽  
Vol 8 (21) ◽  
pp. 5911-5919 ◽  
Author(s):  
Léa Rosselle ◽  
Anna Rita Cantelmo ◽  
Alexandre Barras ◽  
Nadia Skandrani ◽  
Michael Pastore ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Skin Wound ◽  
Butyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Ex Vivo Model ◽  
Nir Light ◽  
Reduced Graphene ◽  
Antibiotic Release ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

NIR-light activable cryogels based on butyl methacrylate and poly(ethylene glycol) methyl ether methacrylate modified with reduced graphene oxide and loaded with cefepime was tested on an infected ex vivo skin model as skin regeneration scaffold.

scholarly journals Construction of NIR Light Controlled Micelles with Photothermal Conversion Property: Poly(poly(ethylene glycol)methyl ether methacrylate) (PPEGMA) as Hydrophilic Block and Ketocyanine Dye as NIR Photothermal Conversion Agent

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1181
Author(s):  
Lan Yao ◽  
Haihui Li ◽  
Kai Tu ◽  
Lifen Zhang ◽  
Zhenping Cheng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Raft Polymerization ◽  
Poly Ethylene Glycol ◽  
Photothermal Conversion ◽  
Nir Light ◽  
Reversible Addition ◽  
Poly Ethylene ◽  
Post Modification ◽  
Glycol Methyl Ether

Polymeric nanomaterials made from amphiphilic block copolymers are increasingly used in the treatment of tumor tissues. In this work, we firstly synthesized the amphiphilic block copolymer PBnMA-b-P(BAPMA-co-PEGMA) via reversible addition-fragmentation chain transfer (RAFT) polymerization using benzyl methacrylate (BnMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA), and 3-((tert-butoxycarbonyl)amino)propyl methacrylate (BAPMA) as the monomers. Subsequently, PBnMA-b-P(APMA-co-PEGMA)@NIR 800 with photothermal conversion property was obtained by deprotection of the tert-butoxycarbonyl (BOC) groups of PBAPMA chains with trifluoroacetic acid (TFA) and post-modification with carboxyl functionalized ketocyanine dye (NIR 800), and it could self-assemble into micelles in CH3OH/water mixed solvent. The NIR photothermal conversion property of the post-modified micelles were investigated. Under irradiation with NIR light (λmax = 810 nm, 0.028 W/cm2) for 1 h, the temperature of the modified micelles aqueous solution increased to 53 °C from 20 °C, which showed the excellent NIR photothermal conversion property.

Magnetite nanoparticles stabilized with polymeric bilayer of poly(ethylene glycol) methyl ether–poly(ɛ-caprolactone) copolymers

Polymer ◽  
2008 ◽  
Vol 49 (18) ◽  
pp. 3950-3956 ◽  
Author(s):  
Siraprapa Meerod ◽  
Gamolwan Tumcharern ◽  
Uthai Wichai ◽  
Metha Rutnakornpituk
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Magnetite Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

The role of hydrogen bonding in alginate/poly(acrylamide-co-dimethylacrylamide) and alginate/poly(ethylene glycol) methyl ether methacrylate-based tough hybrid hydrogels

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57678-57685 ◽  
Author(s):  
Zhi Wei Low ◽  
Pei Lin Chee ◽  
Dan Kai ◽  
Xian Jun Loh
Keyword(s):  
Hydrogen Bonding ◽  
Elastic Modulus ◽  
Ethylene Glycol ◽  
Methyl Ether ◽  
Poly Ethylene Glycol ◽  
Hybrid Hydrogels ◽  
Poly Ethylene ◽  
Glycol Methyl Ether ◽  
Poly Acrylamide

Hybrid hydrogels, with an elastic modulus and compressive toughness of 350 kPa and 70 J m−3, was synthesized and reported here.

Assessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model

2013 ◽  
Vol 33 (5) ◽  
pp. 2584-2594 ◽  
Author(s):  
Szu-Hsien Chen ◽  
Ching-Ting Tsao ◽  
Chih-Hao Chang ◽  
Yi-Ting Lai ◽  
Ming-Fung Wu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Mouse Skin ◽  
Skin Wound ◽  
Poly Ethylene Glycol ◽  
Defect Model ◽  
Glycol Chitosan ◽  
Poly Ethylene ◽  
Chitosan Hydrogels

The Influences of Monomer Structure and Solvent on the Radical Copolymerization of Tertiary Amine and PEGylated Methacrylates

2021 ◽  
Author(s):  
Priscila Quiñonez-Angulo ◽  
Robin Hutchinson ◽  
Angel Licea-Claverie ◽  
Enrique Saldivar ◽  
Ivan Zapata-Gonzalez
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Tertiary Amine ◽  
Radical Copolymerization ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Monomer Structure ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Tertiary Amine Methacrylates (TAMAs), such as 2-(N,N-diethylamino)ethyl methacrylate (DEAEMA) and 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA), and PEGylated (macro)monomers, such as 2-ethoxyethyl methacrylate (EEMA1) and poly(ethylene glycol) methyl ether methacrylates with 9 and...

Copolymerization of Acrylic Monomers and Silane Group Containing Titanium Carbide Nanoparticles for Application to Ophthalmic Lens Materials

2021 ◽  
Vol 21 (8) ◽  
pp. 4388-4393
Author(s):  
Min-Jae Lee ◽  
A-Young Sung
Keyword(s):  
Ethylene Glycol ◽  
Titanium Carbide ◽  
Oxygen Permeability ◽  
Synergy Effect ◽  
Poly Ethylene Glycol ◽  
Propyl Methacrylate ◽  
Acrylic Monomers ◽  
Wetting Agents ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

This research was conducted to synthesis and application for high oxygen permeable ophthalmic lens materials. 2-(Trimethylsiloxy)ethyl methacrylate (2T), 3-[Tris(trimethylsiloxy)silyl]propyl methacrylate (3T), [(1,1-Dimethyl-2-propynyl)oxy]trimethylsilane (TMS), Poly(ethylene glycol) methyl ether methacrylate (PEGMA), N-vinyl-2-pyrrolidone (NVP) and titanium carbide nanoparticles were used as additives for the basic combination of synthesized silicone monomer (SiD) and N,N-Dimethylacetamide (DMA). And also, the materials were copolymerized with ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, azobisisobutyronitrile (AIBN) as the initiator. The copolymerization with a small amount of silane of about 1% increased the oxygen permeability to 30.3˜33.52(cm2/sec)·(mlO2/ml·mm Hg)·10−11, and in particular, the addition of titanium carbide nanoparticles was found to increase to 46.38 (cm2/sec)·(ml O2/ml·mm Hg)·10−11. Surface modification was possible with various wetting agents. Especially, simultaneous use with titanium carbide nanoparticles increased the wettability while maintaining water content. These materials are considered to make synergy effect each other, so it can be used in functional hydrogel ophthalmic lenses.

scholarly journals ID3024 Polymeric nanoparticles display bactericidal effect and selective fermentation for the treatment of acne vulgaris

2017 ◽  
Vol 4 (S) ◽  
pp. 34
Author(s):  
Ming-Fa Hsieh
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Polymeric Nanoparticles ◽  
Acne Vulgaris ◽  
Short Chain Fatty Acids ◽  
Bactericidal Effect ◽  
Skin Microbiome ◽  
Poly Ethylene Glycol ◽  
Effective Doses ◽  
Poly Ethylene

The use of antibiotics in the treatment of acne in specific group (pregnant women) of patients can lead to serious complications. We have previously demonstrated that the nanoparticles made of block copolymers of poly (ethylene glycol) and poly(e-caprolactone) can inhibit the growth of Propionibacterium acnes (P. acnes), a bacterium highly associated with the progress of acne vulgaris in the human skin [Polymers 2016; 8, 321]. To reduce the amount of antibiotics used in the treatment of skin acne, we have further demonstrated that a bacterium in the human skin microbiome can utilize PEG-based polymers to produce various short-chain fatty acids (SCFAs) which suppressed the growth of P. acnes. PEG-based polymers were chosen as selective fermentation initiators which specifically induced the fermentation of the skin commensal bacterium but not P. acnes. Interestingly, PEG-based polymers can efficiently suppress the growth of P. acnes. An acne ex vivo explant was established by using acne biopsies collected from patients with acne vulgaris at the early and middle stages. The levels of pro-inflammatory interleukin (IL)-8 cytokine in early- and middle-staged acnes were significantly higher than those in healthy skins. Incubation of acne ex vivo explants with sucrose remarkably reduced the level of IL-8 and the number of P. acnes. Results from mouse studies revealed that PEG-based polymer functions as antibiotic adjuvants which can considerably reduce the effective doses of clindamycin, a clinically-used acne antibiotic

Sign in / Sign up

Export Citation Format

Share Document